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Tissue Niches & Resident Stem Cells in Adult Epithelia
Gordon Research Conference

Regulation of Tissue Homeostasis by Signaling in the Stem Cell Niche

Dates

August 7-12, 2016

Location

The Hong Kong University of Science and Technology
Hong Kong, China

Organizers

Chairs:
Tudorita Doina Tumbar & Rongwen Xi

Vice Chairs:
Carla Kim & Jane E. Visvader

Hong Kong Advisory Board:
Tony F. Chan, Kathryn Song Eng Cheah, Fanny M.C. Cheung, Arthur B. Ellis, Barry Halliwell, Nancy Ip, Jian Lu, Peter Mathieson, Alfonso Ngan, Paul Tam, Benjamin Wah, Henry Wong, Vivian Wing-Wah Yam, Kenneth Young & Albert Cheung-Hoi Yu More Information

Meeting Description

Adult epithelia regenerate during adult life due to the constant activity of stem cell pools. Stem cells maintain tissue homeostasis and repair injury by close communication with their tissue environment, known as "niche". Niches are complex, structured arrays of different cell types that guide tissue stem cell dynamics. The ultimate goal of understanding epithelial stem cell regulation is to repair or replace cells or organs damaged by injury, disease, and aging. The strategies vary from generating cell types and tissues in a dish for transplantation purposes, to directly stimulating the damaged organ in the living organism. This field has been exponentially growing for the past decade. Tissues such as human skin and cornea have already been grown in 3D cultured and used in clinics to fight otherwise incurable medical conditions. The GRC "Tissue Niches and Resident Stem Cells in Adult Epithelia" will focus on comparative principles of adult epithelial stem cell dynamics and niche signaling in the homeostasis of different tissues. This conference will include work on the molecular control of stem cell function from the epidermis and its appendages, intestine, lung, mammary gland, cornea and retina, epithelial transition zones, and emerging work from other epithelial tissues. All model organisms are welcome. We strongly believe in being inclusive, and hope to inspire a principle of alternating speakers that will allow a variety of participants to contribute to this exciting meeting over the coming years.

Contributors

Final Meeting Program

Sunday
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Signaling Unity Within Epithelial Stem Cell Diversity
Discussion Leader: Rongwen Xi (National Institute of Biological Sciences, China)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 7:55 pmIntroduction by Discussion Leader
7:55 pm - 8:35 pmRoeland Nusse (Stanford University, USA)
"Stem Cells in Liver Homeostasis"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmFiona Watt (King's College London, United Kingdom)
"In Vitro Approaches to Analyze the Epidermal Stem Cell Niche"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpithelial Stem Cells and Their Skin Niches
Discussion Leaders: Fiona Watt (King's College London, United Kingdom) and Xiaoyang Wu (University of Chicago, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amHoward Chang (Stanford University, USA)
"RNA World and Regulation of Gene Expression"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amPritinder Kaur (Curtin University, Australia)
"MSC-Like Dermal Pericytes Influence Epidermal Renewal by Promoting Symmetric Keratinocyte Cell Divisions"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 10:50 amValerie Horsley (Yale University, USA)
"Adipocytes as Niche Cells in Epithelial Tissues"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amXing Dai (University of California, Irvine, USA)
"Keeping Skin and Mammary Epithelial Stem/Progenitor Cells Epithelial"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amVladimir Botchkarev (Boston University, USA / University of Bradford, United Kingdom)
"Epigenetic Regulation of Epidermal Development and Differentiation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAiko Sada (Tsukuba Advanced Research Alliance, University of Tsukuba, Japan)
"Stem Cell Lineages of the Interfollicular Epidermis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSangbum Park (Yale University, USA)
"Coordination of Tissue Homeostasis and Wound Repair Mechanisms in Live Mice"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Fiona Watt (King's College London, United Kingdom) and Jane Visvader (The Walter and Eliza Hall Institute of Medical Research, Australia)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpithelial Stem Cells in Translation
Discussion Leaders: Michele De Luca (University of Modena and Reggio Emilia, Italy) and Andrea Flesken-Nikitin (Cornell University, USA)
7:30 pm - 7:55 pmMichele De Luca (University of Modena and Reggio Emilia, Italy)
"Epidermal Stem-Mediated Combined Cell and Gene Therapy for the Treatment of Epidermolysis Bullosa"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmGraziella Pellegrini (University of Modena and Reggio Emilia, Italy)
"Regenerative Medicine by Corneal Stem Cells: In Vitro and In Vivo Niches"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmNadia Zakaria (Universitaire Ziekenhuis Antwerpen, Belgium)
"Collagen Analogs as Scaffolds for Corneal Regeneration"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmCatherine Lu (The Rockefeller University, USA)
"Identification of Adult Stem Cells in Eccrine Sweat Glands: Wound Repair and Regeneration"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmClare Weeden (The Walter and Eliza Hall Institute of Medical Research, Australia)
"Airway Basal Stem Cells Use Error-Prone DNA Repair in Response to DNA Damaging Agents"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHair Follicle Stem Cells
Discussion Leaders: George Cotsarelis (University of Pennsylvania, USA) and Xinhong Lim (Institute of Medical Biology, A*STAR, Singapore)
9:00 am - 9:25 amGeorge Cotsarelis (University of Pennsylvania, USA)
"Bulge Stem Cells in Mouse and Human Hair Follicles"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amSung-Jan Lin (National Taiwan University, Taiwan)
"Environmental Regulation of Hair Follicle Neogenesis and Regeneration"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amTudorita Doina Tumbar (Cornell University, USA)
"Genetic and Epigenetic Control of Stem Cell Dynamics in and out the Niche"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amTing Chen (National Institute of Biological Sciences, China)
"How to Build a Functional Niche with Stem Cells"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMichael Rendl (Icahn School of Medicine at Mount Sinai, USA)
"Regulation of Hair Follicle Formation, Growth and Regeneration by the Mesenchymal Niche"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmIsaac Brownell (National Cancer Institute, NIH, USA)
"The Perineural Niche as a Regulator of Cutaneous Stem Cells"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmKenneth Lay (The Rockefeller University, USA)
"Foxc1 Governs Hair Follicle Stem Cell Quiescence and Niche Maintenance to Preserve Long-Term Tissue-Regenerating Potential"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
2:00 pm - 4:00 pmPoster Session
4:00 pm - 6:00 pmLung Stem Cells
Discussion Leaders: Brigid Hogan (Duke University, USA) and Nan Tang (National Institute of Biological Sciences, Beijing, China)
4:00 pm - 4:25 pmBrigid Hogan (Duke University, USA)
"Lung Stem/Progenitor Cells and Their Niche During Homeostasis and Repair"
4:25 pm - 4:35 pmDiscussion
4:35 pm - 4:55 pmBarry Stripp (Cedars Sinai Medical Center, USA)
"Progenitor Cell Fate in Airway Repair"
4:55 pm - 5:05 pmDiscussion
5:05 pm - 5:25 pmJoo-Hyeon Lee (University of Cambridge, United Kingdom)
"Regulatory Crosstalk in Lineage Specification of Epithelial Cells During Lung Repair and Regeneration"
5:25 pm - 5:30 pmDiscussion
5:30 pm - 5:40 pmIan Driver (University of California, San Francisco, USA)
"Single Cell Profiling of Adult Lung Heterogeneity: Identification of Novel Cell Types Involved in Regeneration and Disease"
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmRui Zhao (Genomics Institute of the Novartis Research Foundation, USA)
"Tissue Logic in the Airway Epithelium: Plasticity and Regulation"
5:55 pm - 6:00 pmDiscussion
6:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntestinal Stem Cells
Discussion Leaders: Bruce Edgar (Huntsman Cancer Institute, University of Utah Health Care, USA) and Zhengquan Yu (China Agricultural University, China)
9:00 am - 9:25 amBruce Edgar (Huntsman Cancer Institute, University of Utah Health Care, USA)
"Regenerative and Tumorigenic Growth of Drosophila Intestinal Stem Cells"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amTony Ip (University of Massachusetts Medical School, USA)
"The Conserved Misshapen-Yorkie Pathway in Drosophila Intestinal Homeostasis"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amHeinrich Jasper (Buck Institute for Research on Aging, USA)
"Age-Related Stem Cell Dysfunction: Lessons from Drosophila"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amRongwen Xi (National Institute of Biological Sciences, China)
"Fate Specification and Maintenance in the Midgut Stem Cell Lineages"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amNozomi Nishimura (Cornell University, USA)
"In Vivo Imaging of Stem Cells in the Mouse Intestine and Beyond"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:25 pmLucy O'Brien (Stanford University, USA)
"Motile Stem Cells Exhibit Tissue-Level Spatial Order During Steady-State Organ Renewal but Not Adaptive Organ Growth"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmEpithelial Stem Cells of Oral and Craniofacial Complex
Discussion Leaders: Ophir Klein (University of California, San Francisco, USA) and Tsung-Lin Yang (National Taiwan University, Taiwan)
7:30 pm - 7:50 pmOphir Klein (University of California, San Francisco, USA)
"Dynamics of Oral and Dental Epithelial Stem Cells During Homeostasis and Regeneration"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmCatherine Ovitt (University of Rochester, USA)
"Finding a Role for Stem Cells in Salivary Gland Homeostasis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmYang Chai (University of Southern California, USA)
"Molecular Regulation of the Dental Epithelial Stem Cell Niche"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMaria Alcolea (Wellcome Trust/MRC Cambridge Stem Cell Institute, United Kingdom)
"Cell Fate Imbalance in the Oesophageal Epithelium: Mutant Cell Competition"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSarah Knox (University of California, San Francisco, USA)
"Peripheral Nerves Selectively Establish, Maintain and Replenish Salivary Gland Architecture via SOX2"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMammary, Prostate, and Ovarian Stem Cells
Discussion Leaders: Michael Shen (Columbia University Medical Center, USA) and Chang Liu (Columbia University, USA)
9:00 am - 9:30 amMichael Shen (Columbia University Medical Center, USA)
"Progenitor Cells and the Origin of Prostate Cancer"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amLi Xin (Baylor College of Medicine, USA)
"Prostate Epithelial Lineage Hierarchy"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amArial Zeng (Chinese Academy of Sciences, China)
"Procr Stem Cells in Mammary Development and Cancer"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amJane Visvader (The Walter and Eliza Hall Institute of Medical Research, Australia)
"Mapping Stem and Progenitor Cells During Development and Tumorigenesis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmQiang Lan (Institute of Biotechnology, University of Helsinki, Finland)
"Cellular Behavior of Mammary Progenitor Cells During Embryonic Mammary Gland Development"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmWinnie Shum (ShanghaiTech University, China)
"Epithelial Cellular Communication for a Congenial Niche in Excurrent Duct"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmStem Cells of Transitional Zones
Discussion Leaders: Alexander Nikitin (Cornell University, USA) and Guy Lyons (Centenary Institute, Australia)
4:00 pm - 4:25 pmAlexander Nikitin (Cornell University, USA)
"Transitional Zones, Stem Cells and Cancer"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 4:50 pmGeraldine Guasch (Institut Paoli Calmettes, Cancer Research Center of Marseille, France)
"Transitional Epithelium: Merging Microenvironment and Cellular Transformation"
4:50 pm - 4:55 pmDiscussion
4:55 pm - 5:15 pmYusuke Yamamoto (National Cancer Center Research Institute, Japan)
"Enemies from Within: Stem Cells of Metaplastic Precursors of Highly Lethal Cancers"
5:15 pm - 5:20 pmDiscussion
5:20 pm - 5:30 pmJoana Neves (Buck Institute for Research on Aging, USA)
"Immune Modulation by MANF Promotes Tissue Repair and Regenerative Success in the Retina"
5:30 pm - 5:35 pmDiscussion
5:35 pm - 5:45 pmJeff Mumm (Johns Hopkins School of Medicine, USA)
"Innate Immune System Regulation of Retinal Regeneration"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:00 pmClosing Remarks
6:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Any opinions, findings, conclusions or recommendations expressed in this material/event (or by members of the project team) do not reflect the views of the Government of the Hong Kong Special Administrative Region, the Innovation and Technology Commission or the Vetting Committee of the General Support Programme of the Innovation and Technology Fund.

Funding for this conference was made possible (in part) by 1R13AR070558-01 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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