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Alcohol-Induced End Organ Diseases
Gordon Research Conference

Metabolic Reprogramming and Molecular Mechanisms of Tissue Injury by Alcohol

Dates

March 26-31, 2017

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA Site Information

Organizers

Chairs:
Bin Gao & Andras Orosz

Vice Chair:
Laura E. Nagy

Application Deadline

Applications for this meeting must be submitted by February 26, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Gordon Research Conference (GRC) on Alcohol-Induced End Organ Diseases "Metabolic Reprogramming and Molecular Mechanisms of Tissue Injury by Alcohol" will provide a unique forum to bring together a diverse range of young and established scientists who are studying alcohol-related organ damage. This newly approved Gordon Research Conference exclusively addresses alcohol-induced end organ disorders and will cover a broad range of studies at the molecular, cellular, systems, and organismal level, with particular emphasis on multidisciplinary work and innovative approaches. This GRC conference will 1) provide an international forum that promotes open discussion of cutting edge research at the forefront of alcohol-induced tissue injury, 2) foster the development of the next generation of investigators to study alcohol-induced organ damage, 3) promote interaction between young and senior investigators, 4) facilitate the exchange of ideas that will shape the future directions of the alcohol and tissue injury community, and 5) introduce breakthrough techniques that facilitate the understanding of mechanisms driving alcohol-induced tissue injury. This GRC conference will significantly advance current understanding of the underlying mechanisms of end organ injury and stimulate development of effective therapeutic strategies for the diagnosis, prevention and treatment of alcohol-related disorder. Talks will address questions centered on the basic mechanisms that contribute to alcohol-induced organ damage across the entire lifespan and will include wide ranging experimental systems from microbiome to humans. The format will provide ample time for formal and informal discussions and emphasize the presentation of unpublished data, thus ensuring that the newest and most exciting developments in the field are discussed. Poster sessions will take place on each day of the meeting, allowing for widespread participation of conference attendees at all career stages. Speakers will also be selected from submitted abstracts for "late-breaking topic" talks by young investigators. Participation by young investigators will be strongly encouraged.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Novel Mechanisms of Multiple-Organ and Tissue Injury
Discussion Leader: Jan Hoek (Thomas Jefferson University, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmBernd Schnabl (University of California, San Diego, USA)
"Host-Microbiome Interactions in Alcohol-Associated Diseases"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmGyongyi Szabo (University of Massachusetts Medical School, USA)
"Triggers, Pathways and Mediators of Alcohol-Induced Tissue Inflammation"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProteostasis (Protein Homeostasis) in Alcohol-Induced Organ Injury
Discussion Leader: Neil Kaplowitz (University of Southern California, USA)
9:00 am - 9:20 amWen-Xing Ding (University of Kansas Medical Center, USA)
"Autophagy, a Common Mechanism for Alcohol-Induced Liver and Pancreatic Injury"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amStephen Pandol (VA Greater Los Angeles Healthcare System, USA)
"Regulation of Endoplasmic Reticulum Protein Processing with Alcohol"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk Selected from Poster Abstracts
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amPranoti Mandrekar (University of Massachusetts Medical School, USA)
"Targeting Proteostasis Pathways: New Therapeutic Paradigm in Alcoholic Liver Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amSrinivasan Dasarathy (Cleveland Clinic, USA)
"Mechanism of Skeletal Muscle Proteostasis and Sarcopenia in Alcoholic Liver Disease"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAlcohol, Stem Cells, and Cancer
Discussion Leader: Helmut Seitz (University of Heidelberg, Germany)
7:30 pm - 7:50 pmLorraine Gudas (Weill Cornell Medicine, USA)
"The Effects of Alcohol on Epithelial Stem Cells of the Oral Cavity and Esophagus During Carcinogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmVasilis Vasiliou (Yale School of Public Health, USA)
"Aldehyde Dehydrogenases in Cancer Stem Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKeigo Machida (Keck School of Medicine, University of Southern California, USA)
"Cell Fate Decision and Metabolic Reprograming of Tumor-Initiating Stem-Like Cells in Alcohol-Associated Injury and Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmunologic Mechanisms
Discussion Leader: Gavin Arteel (University of Louisville, USA)
9:00 am - 9:20 amCynthia Ju (University of Colorado Health Science Center, USA)
"IL-1 Receptor Like 1 (ST2) Protects Against Alcoholic Liver Injury and Inflammation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amHidekazu Tsukamoto (University of Southern California, USA)
"Caspase 11-Gasdermin-D Pathway in Alcoholic Hepatitis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk Selected from Poster Abstracts
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amFlavia Souza-Smith (LSU Health Sciences Center New Orleans, USA)
"Mesenteric Lymphatic/Perilymphatic Adipose Tissue Crosstalk: Mechanism of Alcohol Immunomodulation"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amElizabeth Kovacs (University of Colorado Denver, USA)
"Alcohol Intoxication and the Pulmonary Inflammatory Response After Injury"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNon-Coding RNA and Extracellular Vesicles
Discussion Leader: David Brigstock (Nationwide Children's Hospital, USA)
7:30 pm - 7:50 pmVijay Shah (Mayo Clinic, USA)
"Extracellular Vesicles and Alcoholic Liver Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLi Wang (University of Connecticut, USA)
"Non-Coding RNA as Novel Regulator of Alcoholic Fatty Liver"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmWon-IL Jeong (KAIST, South Korea)
"Exosomes and TLR3 in Liver Fibrosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAlcohol, Gut Microbiota, Intestinal Barrier Function, and Fat Metabolism
Discussion Leader: Carol Casey (University of Nebraska, USA)
9:00 am - 9:20 amCraig McClain (University of Louisville, USA)
"Alcohol:Fat Interactions in the Development/Treatment of Alcoholic Liver Disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMin You (Northeast Ohio Medical University, USA)
"Adiponectin-FGF15/19 Signaling, a Pivotal Adipose-Gut-Liver Axis in Alcoholic Steatohepatitis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk Selected from Poster Abstracts
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAli Keshavarzian (Rush University Medical Center, USA)
"Microbiota, Gut Leakiness to Endotoxins and Circadian Disruption in Alcohol Use Disorders"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amPatricia Molina (Louisiana State University, USA)
"Alcohol-SIV/HIV-ART Interactions Promote Metabolic Dysregulation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMitochondria in Alcohol-Induced Organ Damage
Discussion Leader: John Lemasters (Medical University of South Carolina, USA)
7:30 pm - 7:50 pmGyorgy Hajnoczky (Thomas Jefferson University, USA)
"Targeting of Mitochondrial Dynamics and Survival Mechanisms by Alcohol in Heart and Liver"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmShannon Bailey (University of Alabama at Birmingham, USA)
"Role of the Circadian Clock in Alcohol-Induced Alterations in Hepatic Mitochondrial Energy Metabolism"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmNarayan Avadhani (University of Pennsylvania, USA)
"Mitochondria-Targeted Cyp2E1 Modulates Alcohol Liver Toxicity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPreclinical/Translational Approaches and Treatment in Alcohol-Associated Diseases
Discussion Leader: Mack Mitchell (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:20 amPhilippe Mathurin (Centre Hospitalier Universitaire de Lille, France)
"Therapeutic Strategy in Severe Alcoholic Hepatitis: From Present to Future Development of New Molecules"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRamon Bataller (University of North Carolina at Chapel Hill, USA)
"Novel Therapeutic Targets for Alcoholic Hepatitis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk Selected from Poster Abstracts
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amGeorge Kunos (National Institutes of Health, USA)
"Multitarget Approach for The Pharmacotherapy of Liver Fibrosis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amShelly Lu (Cedars-Sinai Medical Center, USA)
"Role of SAMe in Liver Injury and Cancer"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmUrszula Iwaniec (Center for Healthy Aging Research, Oregon State University, USA)
"Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPost-Metabolic Signaling and Stress Pathways
Discussion Leader: Charles Lang (Penn State College of Medicine, USA)
7:30 pm - 7:50 pmPal Pacher (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Deleterious Effects of Binge Drinking on Chronic Ethanol Feeding-Induced Metabolic Dysregulation and Cardiovascular Dysfunction in Mice"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJason Gardner (LSU Health Sciences Center New Orleans, USA)
"Alcohol and The Heart: Interference of Compensatory Remodeling"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDaria Mochly-Rosen (Stanford University School of Medicine, USA)
"Ethanol and Precision Medicine: New Considerations for an Old Problem"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

This meeting is supported by AASLD.
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