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Cognitive Dysfunction in Brain Diseases
Gordon Research Conference

Mechanisms and Therapeutic Targets for Cognitive Deficits in Neurologic and Psychiatric Diseases

Dates

June 11-16, 2017

Location

The Chinese University of Hong Kong
Hong Kong, China Site Information

Organizers

Chairs:
Linda Chiu-Wa Lam & Iris Sommer

Vice Chairs:
Yun Kwok Wing & David C. Glahn

Hong Kong Advisory Board:
Tony F. Chan, Kathryn Song Eng Cheah, Fanny M.C. Cheung, Arthur B. Ellis, Barry Halliwell, Nancy Ip, Jian Lu, Peter Mathieson, Alfonso Ngan, Paul Tam, Benjamin Wah, Henry Wong, Vivian Wing-Wah Yam, Kenneth Young & Albert Cheung-Hoi Yu More Information

Application Deadline

Applications for this meeting must be submitted by May 14, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Almost all brain disorders are associated with cognitive impairment. For many clinicians and neuroscientists, cognitive dysfunction is specific for dementia. It is not until recently that the research community has come to appreciate that the degree of cognitive impairment in different brain diseases defines functional outcomes. Cognitive dysfunction has devastating effects on the patient and his/her family. Understanding the mechanisms underlying cognitive dysfunction in various brain diseases, their similarities and differences, will informs new strategies for prevention and treatment. In the past years, much progress has been obtained in the possibilities to assess the neurobiology of cognition with sophisticated assessment and advanced brain imaging techniques, which have greatly enhanced our understanding of the basis of cognitive deficits. More importantly, advanced imaging and genetic evaluations have started to elucidate the impact of lifestyle factors such as physical exercise, nutrition, sleep and biorhythm on cognitive functioning. Consolidation of knowledge in these areas is the key for the development of new treatment regimens, as across disorders there is little evidence for effective treatments to improve cognition at present. The specific aims of this GRC are to bring together experts to share their recent research on the assessment of cognitive dysfunction in different brain disorders using advanced imaging, genetic and cognitive assessment techniques, and on the exploration of innovative lifestyle modulators of brain reserve, neuroplasticity and cognition. The experience of evaluating and intervening cognitive dysfunction through multimodal assessment schema across different brain disorders will hopefully converge to define a new paradigm for transdiagnostic approach towards intervention for optimization of cognition.

Contributors

Meeting Program

Sunday
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBeyond the Boundaries of Diagnoses Across the Lifespan
This session will highlight the dimension of cognitive dysfunction across major brain diseases in different age groups, drawing the similarity beyond current framework for diagnostic classifications.
Discussion Leader: Pak Sham (University of Hong Kong, Hong Kong SAR China)
7:40 pm - 8:15 pmWilliam Honer (University of British Columbia, Canada)
"Plasticity, Pathology and Cognitive Function Across Age and Diagnosis"
8:15 pm - 8:35 pmDiscussion
8:35 pm - 9:10 pmBerry Kremer (University of Groningen, The Netherlands)
"Cognitive and Behavioural Dysfunction in Huntington's Disease: Associations and Mechanisms"
9:10 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetics and Behavior
Advanced genetic evaluation has provided important insights into the development of major neuropsychiatric conditions. Recent explorations appear to inform the clustering of constitutional predisposed physiological functions that modulate behaviors independent of diagnosis. This session will draw the links between genetic studies, cognitive and behavioral disorders.
Discussion Leader: Manabu Ikeda (Osaka University, Japan)
9:00 am - 9:40 amStephan Ripke (Broad Institute of Harvard and MIT, USA)
"Insights from Common Variant Analysis in Schizophrenia About the Genetic Architecture of Cognition"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amTao Li (West China Hospital, Sichuan University, China)
"Multimodal Phenotypic Evaluation for Psychosis"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmYen Kuang Yang (National Cheng Kung University, Taiwan)
"The Gap Between Gene and Behavior in Mental Disorder Studies – A Neuroimaging Perspective"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImaging Cognitive Function and Dysfunction in Alzheimer's Disease and Other Neurocognitive Disorders
The state of the art neuroimaging techniques in elucidating underlying mechanisms for cognitive dysfunction will be introduced. Presentations will expand from the framework of degenerative conditions to other brain disorders.
Discussion Leader: Philip Scheltens (VU University Medical Center, The Netherlands)
7:30 pm - 8:10 pmVincent Mok (The Chinese University of Hong Kong, Hong Kong SAR China)
"Neuroimaging for Small Vessels of the Brain – Implications on Cognition"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmFernando Maestu (Complutense University of Madrid, Spain)
"Functional Network Organization in the Early Stages of Alzheimer's Disease"
9:10 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhysical Activity, Nutrition and the Ageing Brain
There has been increasing interests in the relationship between physical activity, diet and brain function. The protective effects of these lifestyle activities in cognition have mostly been evaluated in older adults. However, the putative mechanisms are not only specific for the ageing brain. This session will discuss on the potential for further research beyond the current paradigm.
Discussion Leader: Timothy Kwok (The Chinese University of Hong Kong, Hong Kong SAR China)
9:00 am - 9:40 amNicola Lautenschlager (University of Melbourne, Australia)
"Physical Activity and Brain Reserve – A Possible Transdiagnostic Intervention"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amMartha Clare Morris (Rush University Medical Center, USA)
"Effects of Lifestyle Behaviors on the Brain: Immediate Versus Longterm"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmNikolaos Scarmeas (Columbia University, USA / Aiginition Hospital, Greece)
"Nutrition and Brain Imaging Biomarkers: Where Are We and Where Do We Want to Be?"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
2:00 pm - 4:00 pmPoster Session
4:00 pm - 6:00 pmTranslational Cognitive Neuroscience
Basic neuroscience research provides models for diseases that are associated with cognitive dysfunction. This session draws on the significance of translation into potential clinical inference through different approaches.
Discussion Leader: Eric Chen (University of Hong Kong, Hong Kong SAR China)
4:00 pm - 4:40 pmPeter Uhlhaas (University of Glasgow, United Kingdom)
"Oscillations and Neuronal Dynamics in Schizophrenia: The Search for Basic Symptoms and Translational Opportunities"
4:40 pm - 5:00 pmDiscussion
5:00 pm - 5:40 pmSookja Chung (The University of Hong Kong, Hong Kong SAR China)
"Transgenic and Knockout Mouse Models for Vascular Mechanisms in Neurodegenerative Disorders"
5:40 pm - 6:00 pmDiscussion
6:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSleep, Biological Rhythm and Neurodegeneration
Sleep and biological rhythms are not only basic physiological function, but also are recognized important clinical manifestations of brain diseases. This session brings into spotlight that biorhythm studies may inform new direction for research in cognitive and neuropsychiatric disorders.
Discussion Leader: Ian Hickie (Brain and Mind Centre, University of Sydney, Australia)
9:00 am - 9:40 amYang Dan (University of California, Berkeley, USA)
"Neural Circuits Controlling Sleep"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amKathleen Merikangas (National Institute of Mental Health, NIH, USA)
"Dysynchrony of Homeostatic Rhythms in Bipolar Disorder"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmDieter Riemann (University Medical Center Freiburg, Germany)
"Sleep, Insomnia and Mental Disorders"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTraumatic Brain Injury
Severe traumatic brain injury (TBI) is well recognized cause for brain damage. Other TBIs may escape clinical attention, and lead to under-recognition of behavioral changes associated with cognitive impairments. This session will draw attention to newly explored risk factors between TBI and cognitive dysfunction.
Discussion Leader: Winnie Chu (The Chinese University of Hong Kong, Hong Kong SAR China)
7:30 pm - 8:10 pmVignerswaran Veeramuthu (Brain and Cognition Recovery Centre (BCRC), Malaysia)
"Advanced Neuroimaging Modalities as Potential Biomarkers in Prognosticating Cognitive Outcomes in Mild Traumatic Brain Injury"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmRong Chen (University of Maryland School of Medicine, USA)
"Altered Cerebellar Anatomical Connectivity in Patients with Mild Traumatic Brain Injury"
9:10 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmInflammation, Immunity and Neuroplasticity
Interests in inflammation and immunity as important mechanisms for brain disorders arose from findings of basic neuroscience research and genetic studies of susceptibility gene loci. This session will explore the mechanisms leading to brain dysfunction, as well as potential for intervention that may modify disease course.
Discussion Leader: Wing Ho Yung (The Chinese University of Hong Kong, Hong Kong SAR China)
9:00 am - 9:40 amOrly Lazarov (University of Illinois at Chicago, USA)
"Neurogenesis and Inflammation in Cognitive Function in the Aging and Disordered Brain"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amSonja Orlovska (Mental Health Centre Copenhagen, University of Copenhagen, Denmark)
"Infections, Autoimmunity and Inflammation's Association with Mental Disorders and Cognition"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmMaja Djurisic (Stanford University, USA)
"Bidirectional Changes in Plasticity Regulated by an Innate Immune Receptor in Neurons – An Endocannabinoid Connection"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmTowards Intervention for Brain Reserve
This session will provide an integrative framework towards the possibility of multimodality intervention to enhance neuroplasticity for cognitive dysfunction from a transdiagnostic perspective.
Discussion Leader: Nicola Lautenschlager (University of Melbourne, Australia)
4:00 pm - 4:30 pmTobias Hartmann (Saarland University, Germany)
"Multi-Nutrient Intervention in Pre-Dementia Alzheimer's Disease"
4:30 pm - 4:40 pmDiscussion
4:40 pm - 5:10 pmMichael Valenzuela (Sydney Medical School, University of Sydney, Australia)
"Neurogenesis in the Live Human Brain: A New MR Spectroscopi Method and Functional Relevance to Psychiatry, Neurodegeneration and Intervention-Related Plasticity"
5:10 pm - 5:20 pmDiscussion
5:20 pm - 5:50 pmMarcus Richards (University College London, United Kingdom)
"A Life Course Approach to Optimizing Cognitive Reserve?"
5:50 pm - 6:00 pmDiscussion
6:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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