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Natural Products and Bioactive Compounds (GRS)
Gordon-Kenan Research Seminar

Chemical and Biological Approaches to Therapeutically Relevant Natural Products and Bioactive Compounds

Dates

July 29-30, 2017

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Eve Granatosky

Meeting Description

The Gordon Research Seminar on Natural Products and Bioactive Compounds is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will focus on a range of diverse topics related to the chemistry and biology of natural products and bioactive compounds, from understanding the basic science of their origins and synthesis, to their potential applications in the context of human health. The program will include a keynote lecture from an expert in the field, oral presentations selected from submitted abstracts, and a session focused on career mentoring and professional development. Abstracts highlighting the cross-disciplinary nature of the field – emphasizing organic synthesis, methodology development, isolation and characterization, biosynthesis, chemical and synthetic biology, and biological evaluation – are strongly encouraged.

Related Meeting

This GRS was held in conjunction with the "Natural Products and Bioactive Compounds" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Structural Biology and Natural Product Biosynthesis
Discussion Leader: Constance Bailey (Lawrence Berkeley National Laboratory, USA)
3:45 pm - 4:20 pmJanet Smith (University of Michigan, USA)
"Synthesis of Branched Starter Units by Polyketide Synthase Loading Modules"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmUnderstanding the Function and Bioactivity of Natural Products
Discussion Leaders: Taylor Hari (University of Ottawa, Canada) and Robert Ziegler (Massachusetts Institute of Technology, USA)
7:30 pm - 7:45 pmNagasandhya Guntaka (University of Florida, USA)
"A Structural Biology Approach Reveals Key Aspects in Colibactin Biosynthesis and Mechanism of Microbiome-Associated Action"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmAndrew Gasparrini (Washington University in St. Louis, USA)
"Characterization and Inhibition of Emerging Tetracycline Resistance Enzymes"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmLaura Mike (University of Michigan, USA)
"Discovery of Nicoyamycin A, an Inhibitor of Uropathogenic Escherichia coli Growth in Low Iron Environments"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmDavid Fazakerley (Aberystwyth University, United Kingdom)
"Potent Bioactive Naphthoquinone Discovered in Problematic Invasive Weed"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMary Egbuta (Southern Cross University, Australia)
"Bioactive Volatiles Extracted from Cotton Waste Products"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amAccessing New Scaffolds: Chemistry and Biosynthesis
Discussion Leaders: Fan Liu (Harvard University, USA) and Graham Heberlig (University of Ottawa, Canada)
9:00 am - 9:15 amBethany Okada (Princeton University, USA)
"Natural Product Discovery in Burkholderia thailandensis Through Cryptic Gene Cluster Activation"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amKwo-Kwang Wang (University of Illinois at Urbana-Champaign, USA)
"Investigating the Biosynthesis of Fosfazinomycin, a Natural Product Containing a Unique Hydrazide Linkage"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amMasha Elkin (Yale University, USA)
"Total Synthesis of (±)-Berkeleyone A"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amPatrick Dobrounig (Graz University of Technology, Austria)
"Synthesis of an Amphiphilic Oligoaryl-Based ApoA1 Mimetic"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amEric Welin (California Institute of Technology, USA)
"Asymmetric Total Synthesis of (-)-Jorumycin"
10:35 am - 10:40 amDiscussion
10:40 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Breakout Sessions
Rather than a traditional panel discussion, this session will allow attendees to rotate through small, informal breakout sessions with the invited career mentors, to hear their insights on professional development and career planning.
Discussion Leader: Michelle Goettge (University of Illinois, USA)
1:30 pm - 2:30 pmPanel Discussion
"Careers in Natural Products Chemistry and Biology"
  • James Leahy (University of South Florida, USA)
  • Anne Osbourn (John Innes Centre, United Kingdom)
  • Joshua Pierce (North Carolina State University, USA)
  • Elaine Lee (Vertex Pharmaceuticals, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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