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Nitric Oxide (GRS)
Gordon Research Seminar

Nitric Oxide Biochemistry in Mammalian, Plant, and Microbial Systems

Dates

February 18-19, 2017

Location

Ventura Beach Marriott
Ventura, CA Site Information

Organizers

Chairs:
Courtney E. Sparacino Watkins & Filip Larsen

Application Deadline

Applications for this meeting must be submitted by January 21, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by November 18, 2016. Please refer to the application instructions in the Meeting Description section below for more details (if available).

Meeting Description

Overview

Conference Overview: The Gordon Research Seminar (GRS) is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. All GRS attendees are expected to actively participate by giving an oral presentation or presenting a poster. Attendees are strongly encouraged to attend the preceding Gordon Research Conference (GRC) on nitric oxide at the same venue. The GRS compliments the GRC, occurring at the same venue and immediately preceding the GRC, but caters to students and early career investigators. GRS offers scientific, career, and leadership opportunity for early phase investigators, elaborated below.

Scientific component: The first GRS on nitric oxide (NO) will be held on February 18-19, 2017 in Ventura CA and will explore NO biochemistry in mammalian, plant, and microbial systems. While the molecular mechanisms of NO production, metabolism, and function differ among in living organisms, understanding NO biochemistry in multiple systems can offer invaluable insights. The goal of the 2017 GRS on NO is to broaden our understanding of the NO molecule by connecting researchers from diverse research backgrounds.

The GRS on NO will consist of four sessions: The conference will begin with a keynote lecture (Session 1) from Professor Serpil Erzurum, an international expert in nitric oxide in lung physiology and pathophysiology. The subsequent two scientific session will focus on NO biochemistry in mammals (Session 2) and in plants and microbes (Session 3). Session 2 will focus on nitric oxide biosynthesis, transformation, and function in humans and animal models of human disease. Session 3 will focus the mechanisms of nitric oxide formation and signaling in plant and microbial systems, with a focus on the environmental and microbiome implications. Both sessions will feature oral and poster presentations by attendees. Oral presentation will be selected from abstracts submitted to the conference by November 18, 2016. Both scientific sessions will have a dedicated time slot for poster presentations. Posters will be displayed in an adjacent lecture hall throughout the conference to facilitate discussion among attendees. The GRS will conclude with a career development seminar (Session 4) which is elaborated below.

Career Development Component: Session 4 is dedicated to career development and will focus on how to complete an effective and efficient research fellowship. Instead of a lecture format, we organized a panel of established investigators and mentors (Drs. Rakesh Patel, Victor Darley-Usmar, and Serpil Erzurum) to answer questions proposed by the GRS audience. Come prepared to ask questions on career development and participate in this informative and inclusive group discussion.

Leadership: Because this is the first GRS on NO, we must establish a group of early career investigators in the NO field to carry on the GRS tradition by organizing subsequent conferences. Elections for the 2019 NO GRS co-chairs will be conducted during the 2017 conference. Every attendee will have the opportunity to vote for the next NO GRS co-chairs. Additionally, individuals interested in soliciting funds for the GRS, leveraging social media, and acting as discussion leaders, are encouraged to contact the GRS chairs.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by November 18, 2016. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Nitric Oxide" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Nitric Oxide in Lung Physiology and Pathophysiology
Discussion Leader: Carl Koch (University of Pittsburgh, USA)
3:45 pm - 4:15 pmSerpil Erzurum (The Cleveland Clinic Foundation, USA)
"Nitric Oxide in Lung Physiology and Pathophysiology"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNitric Oxide Biochemistry in Human and Animal
This session will focus on mammalian nitric oxide biosynthesis, transformation, and function in humans and animal models of human disease.
Discussion Leaders: Matthew Amdahl (University of Pittsburgh, USA) and Kenneth Childers (University of Maryland, Baltimore County, USA)
7:30 pm - 7:45 pmVanessa Kress (University of Cologne, Germany)
"Regulation of GABAA Receptor Clustering by Gephyrin S-Nitrosylation and Dynein Light Chain"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmMaria Peleli (Karolinska Institutet, Sweden)
"ROS Producing Enzymes as Targets and Regulators of the Nitrate-Nitrite-NO Pathway: Implications in Hypertension, Metabolic Disease and Innate Immune Cells"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmZahra Bahadoran (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Iran)
"Nitrate/Nitrite Intake and Type 2 Diabetes"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmZixue Jin (Baylor College of Medicine, USA)
"Argininosuccinate Lyase Deficiency as a Model to Study Nitric Oxide Function in Bone"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmPrattusha Sengupta (AU-KBC Research Centre, Anna University, India)
"Enhancing Shelf Life of Stored Red Blood Cells with Nitric Oxide"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShuai Yuan (LSU Health Sciences Center Shreveport, USA)
"Cystathionine Gamma-Lyase Modulates Flow-Dependent Vascular Remodeling"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNitric Oxide Biochemical Mechanisms and Methods
This session will focus the molecular mechanisms of nitric oxide formation and signaling, as well as NO detection methodology.
Discussion Leaders: Mauro Tiso (American University, USA) and Haitham Amal (Massachusetts Institute of Technology, USA)
9:00 am - 9:15 amLuisa Maia (Research Unit on Applied Molecular Biosciences (UCIBIO), REQUIMTE / Universidade Nova de Lisboa, Portugal)
"Nitrite Reduction by Molybdoenzymes: A Ubiquitous Pathway to Generate Nitric Oxide"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amDanielle Guimaraes (University of Pittsburgh, USA)
"Nitrite Inhibits Mitochondrial Phosphodiesterase and Activates cAMP-PKA-AKAP1 Signaling to Modulate Mitochondrial Function and Cytoprotection in Normoxia"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amDominique Williams (Stony Brook University, USA)
"Nitric Oxide Regulation of Cyclic di-GMP Signaling and Biofilm Formation in Agrobacterium vitis"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amMauro Siragusa (Goethe University Frankfurt, Germany)
"Phosphorylation of eNOS on Tyrosine 656 Contributes to Endothelial Dysfunction In Vivo"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amAlexandria Nichols (University of Alabama at Birmingham, USA)
"Improved Method of Oral Microbe Nitrate Reductase Activity Measurement"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amLoruhama Delgado Rivera (University of Illinois at Chicago, USA)
"Discovery and Design of Inhibitors of H2S Synthesizing Enzymes"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Panel Discussion: How to Complete an Effective and Efficient Research Fellowship
A panel of established academic mentors (Drs. Erzurum, Patel, Cortese-Krott and Darley-Usmar) will answer questions from the graduate student and post-doctoral GRS attendees. We will cover topics such as leadership, interviewing, and industry vs academia.
Discussion Leader: Shathiyah Kulandavelu (Interdisciplinary Stem Cell Institute, University of Miami, USA)
1:30 pm - 2:30 pmPanel Discussion
"How to Complete an Effective and Efficient Research Fellowship"
  • Victor Darley-Usmar (University of Alabama at Birmingham, USA)
  • Serpil Erzurum (The Cleveland Clinic Foundation, USA)
  • Rakesh Patel (University of Alabama at Birmingham, USA)
  • Miriam Cortese-Krott (Heinrich Heine University Dusseldorf, Germany)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13HL135874-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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