Gordon Research Conferences
Meeting Details

Nucleic Acids (GRS)
Gordon-Kenan Research Seminar

Mechanistic Insights into RNA and DNA Processes Throughout Biology


June 3-4, 2017


University of New England
Biddeford, ME


Lu Han & Yuqian Shi

Meeting Description

The Gordon Research Seminar on Nucleic Acids is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas on all aspects of the biology and chemistry of Nucleic Acids. The relaxed and sociable atmosphere of the meeting provides a unique environment for extended scientific discussion and interactions.

The 2017 Nucleic Acids GRS will include a keynote talk by Jonathan Weissman (University of California, San Francisco/HHMI), a featured talk by Karen Cone (Program Director, Division of Molecular & Cellular Biosciences) of the National Science Foundation, as well as three platform sessions with a total of 10-15 talks selected from abstracts, and two poster sessions. Sessions will be chaired by selected students/postdocs.

Related Meeting

This GRS was held in conjunction with the "Nucleic Acids" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmMechanistic Insights into RNA and DNA Processes
Discussion Leader: Alexander Johnson (Stanford University, USA)
3:45 pm - 3:55 pmNiladri Sinha (University of Utah, USA)
"The End Is in Sight - Mechanisms of Termini-Dependent Recognition and Cleavage by Dicer"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 4:10 pmTina Liu (University of California, Berkeley, USA)
"Mechanism of Co-Transcriptional DNA and RNA Targeting by a Type III-A CRISPR-Cas Complex"
4:10 pm - 4:15 pmDiscussion
4:15 pm - 4:25 pmXieyang Guo (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CERBM, France)
"Taking a Break: How a Transcription Factor Helps RNA Polymerase to Pause During Transcription"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDNA and RNA Biology and Applications to Human Disease
Discussion Leaders: Bhalchandra Rao (University of Colorado Boulder / Howard Hughes Medical Institute, USA) and Diego Vargas Blanco (Worcester Polytechnic Institute, USA)
7:30 pm - 7:40 pmAgnes Karasik (Uniformed Services University of the Health Sciences, USA)
"Human Pathogenic tRNA Mutations Influence 5'-End tRNA Processing in the Mitochondria"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmJiyu Wang (University of Rochester, USA)
"Defining Mechanisms that Maintain Reading Frame in Eukaryotic Translation"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAndreas Moor (Weizmann Institute of Science, Israel)
"Global mRNA Polarization in the Intestinal Epithelium Regulates Translation Efficiency"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmSneha Rath (Princeton University, USA)
"Innate Immune Endoribonuclease RNase L Balances Between Proliferation Control and Apoptosis Based on dsRNA Load"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmAmmar Naqvi (Children's Hospital of Philadelphia, USA)
"Aberrant Splicing in B-Cell Acute Lymphoblastic Leukemia"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSara Rouhanifard (University of Pennsylvania, USA)
"Fluorescent Amplification of Individual mRNAs in Single Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMaria Loressa Uson (Weill Cornell Graduate School of Medical Sciences, USA)
"The DNA Repair Repertoire of Mycobacterium smegmatis FenA Includes the Incision of DNA 5' Flaps and the Removal of 5' Adenylylated Products of Aborted Nick Ligation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmVedia Yerlici (Princeton University / Columbia University Medical Center, USA)
"The Role of KU Proteins in Genome Maintenance and Programmed Genome Rearrangement in the Ciliate Oxytricha trifallax"
9:25 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amSpecificity and Structure in Nucleic Acid Processes
Discussion Leaders: Yicheng Long (University of Colorado Boulder / Howard Hughes Medical Institute, USA) and Quan Lam (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:10 amJuan Tosar (Institut Pasteur de Montevideo, Uruguay)
"Extracellular-Enriched tRNA Halves Assemble into Nuclease-Resistant Oligomers with Potent Immunostimulatory Activity"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amNathan Howell (Ohio State University, USA)
"A Family Expands: Characterization of Human TRMT10B, a Multifunctional tRNA Methyltransferase"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amTien-Hao Chen (Ohio State University, USA)
"Substrate Recognition by Arabidopsis Proteinaceous RNase P Isoenzymes: Insights into Catalysis"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amWeihan Li (University of California, San Francisco, USA)
"Evolutionary Divergence of IRE1 RNase Specificity Shapes the Unfolded Protein Response"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amChad Torgerson (Yale University, USA)
"High-Throughput Mutational Analysis of the Glycine Riboswitch by Sequencing"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amEric Strobel (Northwestern University, USA)
"Characterization of Cotranscriptional RNA Structure Using SHAPE-Seq"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amIndrajit Lahiri (University of California, San Diego, USA)
"How Does Transcription Avoid Roadblocks?"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amRebecca Keener (Johns Hopkins School of Medicine, USA)
"Tel1(ATM) and Mec1(ATR) Domain Swaps in S. cerevisiae to Distinguish Telomere Length and DNA Damage Functions"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Development and Mentorship
Discussion Leaders: Tina Liu (University of California, Berkeley, USA) and Simona Graziano (Saint Louis University School of Medicine, USA)
1:30 pm - 1:50 pmKaren Cone (National Science Foundation, USA)
"How to Get Funded by the National Science Foundation"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmJane Jackman (Ohio State University, USA)
"Now What? Taking the Next Steps Towards Your Career in Science"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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