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Proteins (GRS)
Gordon Research Seminar

From Protein Structure, Dynamics, and Design to Interaction Networks

Dates

June 17-18, 2017

Location

Holderness School
Holderness, NH Site Information

Organizers

Chairs:
Nathaniel Stanley & Martin Fossat

Application Deadline

The application deadline for this meeting was May 20, 2017. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

Overview

The Gordon Research Seminar on Proteins is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is on recent advances in our understanding of the way proteins shape biology. Specific sub-topics include: protein modeling and design; dynamics and allostery; membrane and vesicle management; nuclear organization; intrinsically disordered proteins; biogenesis and interactions.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by March 17, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Proteins" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmIntrinsically Disordered Proteins
Discussion Leader: Robert Levenson (University of California, Santa Barbara, USA)
3:45 pm - 4:00 pmSneha Roy (Jawaharlal Nehru University, Delhi, India)
"EGCG Disaggregates Gamma-Synuclein Fibrils and Modulates the Pathway to Form Stable and Distinct Oligomeric Species"
4:00 pm - 4:05 pmDiscussion
4:05 pm - 4:20 pmDi Wu (Florida State University, USA)
"Designed Mutations Alter the Binding Pathways of an Intrinsically Disordered Protein"
4:20 pm - 4:25 pmDiscussion
4:25 pm - 4:30 pmGeneral Discussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein Modeling, Design, and Evolution
Discussion Leader: Kevin Yang (California Institute of Technology, USA)
7:30 pm - 7:55 pmMaria Luisa Romero Romero (Weizmann Institute of Science, Israel)
"How Did the First Protein(s) Evolve?"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmHector Garcia Seisdedos (Weizmann Institute of Science, Israel)
"Proteins Evolve on the Edge of Supramolecular Self-Assembly"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmShao-Qing Zhang (University of California, San Francisco, USA)
"De Novo Design of Polynuclear Transition-Metal Clusters in Helical Bundles"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmSurbhi Sharma (University of Nevada, Las Vegas, USA)
"Investigating the Molecular Functions of the Carboxyl End of Human Proteome by Affinity Mass-Spectrometry"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amProtein Localization and Interactions
Discussion Leader: Shao-Qing Zhang (University of California, San Francisco, USA)
9:00 am - 9:25 amDeniz Aydin (Swiss Federal Institute of Technology (EPFL), Switzerland)
"An Integrated Computational and Experimental Study to Investigate the Role of COQ8 in Promoting CoQ Biosynthesis at the Mitochondrial Membrane"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amCaitlin Davis (University of Illinois at Urbana-Champaign, USA)
"Spliceosomal U1A Protein-SL2 RNA Binding Affinity Decreases in Cells"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amFlorian Heinkel (University of British Columbia, Canada)
"Virulent Phase Separation in Mycobacterium tuberculosis"
10:25 am - 10:30 amDiscussion
10:30 am - 10:55 amKevin Yang (California Institute of Technology, USA)
"Machine Learning to Predict Eukaryotic Expression and Plasma Membrane Localization of an Integral Membrane Protein"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmProtein Dynamics and Allostery
Discussion Leader: Di Wu (Florida State University, USA)
1:30 pm - 1:55 pmRobert Levenson (University of California, Santa Barbara, USA)
"Neutralization of a Distributed Coulombic Switch Tunes Reflectin Assembly"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:25 pmChristopher Wilson (Brandeis University, USA)
"Ancient Origins of Allosteric Activation"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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