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Stress Proteins in Growth, Development & Disease (GRS)
Gordon Research Seminar

A Multidimensional View of Proteostasis: From Structure and Function to Human Disease and Aging

Dates

July 8-9, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME Site Information

Organizers

Chairs:
Alex M. Jaeger & Martin Gamerdinger

Application Deadline

Applications for this meeting must be submitted by June 10, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by April 8, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).

Meeting Description

Overview

The Gordon Research Seminar on Stress Proteins in Growth, Development and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This GRS will explore the breadth of influence that protein homeostasis imparts on biological processes. This will be accomplished through interactive discussions related to protein structure and function. These mechanistic, biochemical insights will lay the foundation for discussions on complex human conditions where protein homeostasis is disrupted including neurodegenerative disease, cancer, and aging. The discussions will be highlighted by a keynote address from a leader in the field of protein homeostasis, as well as opportunities to interact with other senior leaders in a collaborative atmosphere.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by April 8, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Stress Proteins in Growth, Development & Disease" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Heat Shock Proteins: Chaperoning Proteins from the Cradle to the Grave
Discussion Leader: Martin Gamerdinger (University of Konstanz, Germany)
3:45 pm - 4:20 pmHarm Kampinga (University Medical Center Groningen, The Netherlands)
"Heat Shock Proteins: Chaperoning Proteins from the Cradle to the Grave"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms Regulating Protein Folding and Aggregation
Discussion Leader: Olga Sin (Max Planck Institute for Molecular Biomedicine, Germany)
7:30 pm - 7:40 pmThomas Alderson (National Institutes of Health, USA)
"Redox Regulation of HSP27 Through Conditional Disorder"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmAlexander Alexandrov (Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Russia)
"Formation of Protein Deposits in Response to Glucose Depletion and Hyperosmotic Stress in Yeast"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAmy Ford (UTHealth Graduate School of Biomedical Sciences at Houston, USA)
"Deciphering Impacts of Thiol Stress on Cytosolic Proteostasis in Yeast"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmRebecca Freilich (University of California, San Francisco, USA)
"Disrupting Hsp27's Oligomeric Contacts Enhances Chaperone Activity"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMadhu-Sudhan Ravindran (University of Michigan, USA)
"A Non-Enveloped Virus Exploits Host Quality Control Machineries to Translocate Across the Endoplasmic Reticulum Membrane"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSabine Schmidt (University of Konstanz, Germany)
"Fluorescence-Based Analysis of Ribosome Assembly In Vivo"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMang Zhu (University of British Columbia, Canada)
"Investigation of Macromolecular Aggregates After Heat-Shock in Unstressed and Heat Stressed Yeast Cells"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAmbadi Sabareesan (National Center for Biological Sciences, India)
"Molecular Mechanism of the Prion Protein Aggregation and Aggregate Mediated Toxicity"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amStress Protein Networks in Aging and Disease
Discussion Leader: Giorgio Gaglia (Whitehead Institute for Biomedical Research, MIT, USA)
9:00 am - 9:10 amStefanos Aivazidis (University of Colorado Denver, USA)
"The Burden of Trisomy 21 Disrupts the Proteostasis Network in Down Syndrome"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amLindsey Baker (Cold Spring Harbor Laboratory, USA)
"Changes in Protein Homeostasis and Response to Proteotoxic Stress Are Associated with Pancreatic Tumorigenesis"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amMaria Khokhrina (DKFZ-ZMBH Alliance, University of Heidelberg, Germany)
"INQ Formation Facilitates DNA Checkpoint Inactivation"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amNirmala Parajuli (University of Arkansas for Medical Sciences, USA)
"Role of Ubiquitin Proteasome System During Cold Storage Plus Transplantation"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amGreg Sienski (Whitehead Institute for Biomedical Research, MIT, USA)
"Molecular Mechanism of Action of a Major Alzheimer's Disease Risk Factor"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amKe Xia (Rensselaer Polytechnic Institute, USA)
"Increased Levels of Hyper-Stable Chaperone and Protein Aggregates in Plasma of Older Adults"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amJay Goodman (University of California, Berkeley, USA)
"Protein Homeostasis and Vacuolar Remodeling in Budding Yeast Gametogenesis"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amDoris Hellerschmied (Yale University, USA)
"Unfolding of a Golgi-Localized Protein Identifies Important Protein Quality Control Mechanisms in the Early Secretory Pathway"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Effective Scientific Networking and Communication
An open forum to discuss effective ways to network and develop collaborations at the GRC.
Discussion Leader: Alex Jaeger (Whitehead Institute for Biomedical Research, MIT, USA)
1:30 pm - 2:30 pmPanel Discussion
"Effective Scientific Networking and Communication"
  • James Bardwell (University of Michigan / Howard Hughes Medical Institute, USA)
  • Harm Kampinga (University Medical Center Groningen, The Netherlands)
  • David Allan Drummond (University of Chicago, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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