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Stress Proteins in Growth, Development & Disease (GRS)
Gordon Research Seminar

A Multidimensional View of Proteostasis: From Structure and Function to Human Disease and Aging

Dates

July 8-9, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chairs:
Alex M. Jaeger & Martin Gamerdinger

Meeting Description

The Gordon Research Seminar on Stress Proteins in Growth, Development and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This GRS will explore the breadth of influence that protein homeostasis imparts on biological processes. This will be accomplished through interactive discussions related to protein structure and function. These mechanistic, biochemical insights will lay the foundation for discussions on complex human conditions where protein homeostasis is disrupted including neurodegenerative disease, cancer, and aging. The discussions will be highlighted by a keynote address from a leader in the field of protein homeostasis, as well as opportunities to interact with other senior leaders in a collaborative atmosphere.

Related Meeting

This GRS was held in conjunction with the "Stress Proteins in Growth, Development & Disease" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Heat Shock Proteins: Chaperoning Proteins from the Cradle to the Grave
Discussion Leader: Martin Gamerdinger (University of Konstanz, Germany)
3:45 pm - 4:20 pmHarm Kampinga (University Medical Center Groningen, The Netherlands)
"Heat Shock Proteins: Chaperoning Proteins from the Cradle to the Grave"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms Regulating Protein Folding and Aggregation
Discussion Leader: Olga Sin (Max Planck Institute for Molecular Biomedicine, Germany)
7:30 pm - 7:40 pmThomas Alderson (National Institutes of Health, USA)
"Redox Regulation of HSP27 Through Conditional Disorder"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmAmy Ford (UTHealth Graduate School of Biomedical Sciences at Houston, USA)
"Deciphering Impacts of Thiol Stress on Cytosolic Proteostasis in Yeast"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmMadhu-Sudhan Ravindran (University of Michigan, USA)
"A Non-Enveloped Virus Exploits Host Quality Control Machineries to Translocate Across the Endoplasmic Reticulum Membrane"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmSabine Schmidt (University of Konstanz, Germany)
"Fluorescence-Based Analysis of Ribosome Assembly In Vivo"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMang Zhu (University of British Columbia, Canada)
"Investigation of Macromolecular Aggregates After Heat-Shock in Unstressed and Heat Stressed Yeast Cells"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmDan Gestaut (Stanford University, USA)
"Structural and Mechanistic Characterization of the TRiC Prefoldin Folding Pathway"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmChristiane Iserman (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Stress Granule Assembly Is Hierarchical and Mediated by Stress-Induced Phase Separation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJoseph Schonhoft (The Scripps Research Institute, USA)
"Peptide Probes Detect Misfolded Transthyretin Oligomers in the Plasma of Early Stage Hereditary Amyloidosis Patients"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amStress Protein Networks in Aging and Disease
Discussion Leader: Giorgio Gaglia (Whitehead Institute for Biomedical Research, MIT, USA)
9:00 am - 9:10 amStefanos Aivazidis (University of Colorado Denver, USA)
"The Burden of Trisomy 21 Disrupts the Proteostasis Network in Down Syndrome"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amLindsey Baker (Cold Spring Harbor Laboratory, USA)
"Changes in Protein Homeostasis and Response to Proteotoxic Stress Are Associated with Pancreatic Tumorigenesis"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amGreg Sienski (Whitehead Institute for Biomedical Research, MIT, USA)
"Molecular Mechanism of Action of a Major Alzheimer's Disease Risk Factor"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amKe Xia (Rensselaer Polytechnic Institute, USA)
"Increased Levels of Hyper-Stable Chaperone and Protein Aggregates in Plasma of Older Adults"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amJay Goodman (University of California, Berkeley, USA)
"Protein Homeostasis and Vacuolar Remodeling in Budding Yeast Gametogenesis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amDoris Hellerschmied (Yale University, USA)
"Unfolding of a Golgi-Localized Protein Identifies Important Protein Quality Control Mechanisms in the Early Secretory Pathway"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amAdam De Graff (Stony Brook University, USA)
"Maintaining Proteostasis Till the Last Breath"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amNirmala Parajuli (University of Arkansas for Medical Sciences, USA)
"Role of Ubiquitin Proteasome System During Cold Storage Plus Transplantation"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Effective Scientific Networking and Communication
An open forum to discuss effective ways to network and develop collaborations at the GRC.
Discussion Leader: Alex Jaeger (Whitehead Institute for Biomedical Research, MIT, USA)
1:30 pm - 2:30 pmPanel Discussion
"Effective Scientific Networking and Communication"
  • James Bardwell (University of Michigan / Howard Hughes Medical Institute, USA)
  • Harm Kampinga (University Medical Center Groningen, The Netherlands)
  • David Allan Drummond (University of Chicago, USA)
  • Ursula Jakob (University of Michigan, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13AG057030-01 from the NIA. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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