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Food Allergy
Gordon Research Conference

Mechanisms, Prevention of, and Emerging Therapies for Food Allergy

Dates

January 7-12, 2018

Location

Ventura Beach Marriott
Ventura, CA Site Information

Organizers

Chair:
Kari C. Nadeau

Vice Chair:
Gideon Lack

Application Deadline

Applications for this meeting must be submitted by December 10, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

As the importance of food allergy is gaining global awareness, this first Gordon Research Conference on Food Allergy will uniquely focus on food-allergen-specific immune function in health and disease. In the past 15 years, more than 9,500 articles have been published in food allergy. Nonetheless, these developments have yet to change the standard of clinical care for food allergy — complete avoidance of the allergenic food. The pressing need for effective therapies for food allergy can only be met by developing a deeper and more comprehensive understanding of immune mechanisms. We aim to amplify the increasing momentum of research advances in food allergy with this new GRC focused specifically on its basic and translational aspects from diverse disciplinary perspectives.

Leading researchers from around the world with expertise in immunology, molecular and cell biology, and computational biology who are interested in understanding healthy and food-allergic immune function will be featured, including those who study emerging problems such as the role of the microbiome in food allergy, and the mechanisms of desensitization achieved through emerging therapies such as oral immunotherapy. This five-day international scientific conference encouraging free discussion — often of unpublished research — aims to provide cross-fertilization and collaboration among researchers in relevant fields, and will help to develop and integrate this rapidly evolving field.

The deadline for poster abstract submission is Tuesday October 31, 2017.

Contributors

Gordon Research Conferences
Cour Pharmaceuticals
Aimmune Therapeutics
BEFORE Brands, Inc.
Vedanta Biosciences
Sean N. Parker Center for Allergy & Asthma Research, Stanford University
The Rockefeller University Press - The Journal of Experimental Medicine

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Global Impact of Food Allergy
Discussion Leaders: Zuhair Ballas (University of Iowa, USA) and Dale Umetsu (Genentech, USA)
7:40 pm - 8:10 pmGideon Lack (King's College London, United Kingdom)
"Lessons We Have Learned from Early Childhood Exposure to Peanut"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmDaniel Rotrosen (National Institute of Allergy and Infectious Diseases, NIH, USA)
"NIAID's Strategic Approach to Food Allergy Research"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmAntonella Muraro (Padua General University Hospital, Italy)
"Optimizing Translation Research and Implementation of Best Practice of Care for Food Allergy"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:05 pmKatie Allen (Murdoch Childrens Research Institute, Australia)
"The Five Ds of Food Allergy Prevention – Is There More to the Food Allergy Epidemic than Diet Alone"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmMichael Levin (University of Cape Town / Red Cross War Memorial Children's Hospital, South Africa)
"Alpha Gal in Rural African Subjects"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmunological Mechanisms of Food Allergy and Tolerance
Discussion Leaders: Hugh Sampson (Icahn School of Medicine at Mount Sinai, USA) and Alkis Togias (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:10 amCarlos Camargo (Massachusetts General Hospital / Harvard University, USA)
"Epidemiological Evidence for the Atopic March"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amRobert Wood (Johns Hopkins University School of Medicine, USA)
"Exciting New Therapies"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amDonald Leung (National Jewish Health, USA)
"The Role of Staphylococcus aureus in Food Allergy"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amRuby Pawankar (Nippon Medical School, Japan)
"The Microbiome and Changing Patterns of Food Allergies in Asia"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amStephanie Eisenbarth (Yale University School of Medicine, USA)
"What a Rare Immunodeficiency Can Teach Us About the Immunological Mechanisms of Food Allergy"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAnuradha Ray (University of Pittsburgh School of Medicine, USA)
"Mitochondrial Control of Immune Tolerance to Allergens"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRuslan Medzhitov (Yale School of Medicine, USA)
"Food Surveillance by the Immune System"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmStephen Quake (Stanford University, USA)
"Genomic Serology, Proteomics, and Allergies"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMichiko Oyoshi (Boston Children's Hospital / Harvard Medical School, USA)
"Induction of Neonatal Tolerance Through Breast Milk"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Rosemarie Dekruyff (Stanford University School of Medicine, USA) and Cathryn Nagler (The University of Chicago, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Role of T Cells in Food Allergy
Discussion Leader: Talal Chatila (Harvard Medical School, USA)
7:30 pm - 7:40 pmErik Wambre (Benaroya Research Institute, USA)
"Deconvoluting Heterogeneity in the CD4+ T Cell Responses to Food Allergen"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmLars Poulsen (University of Copenhagen, Denmark)
"Mapping Epitope Targets of T Cells in Food Allergy"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmPamela Guerrerio (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Investigation of Peanut-Specific T Effector and T Regulatory Cells in Children Allergic and Tolerant to Peanut"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmAnne Singh (University of Wisconsin-Madison, USA)
"Regulatory T Cells in Food Allergy"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmWilli Born (National Jewish Health, USA)
"Pre-Immune Influence of Gamma Delta T Cells on B Lymphocytes and Antibodies"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmYueh-Hsiu Chien (Stanford University School of Medicine, USA)
"Gamma Delta T Cells in Allergy"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPreventing Food Allergy: From Skin to Gut
Discussion Leaders: Marshall Plaut (National Institutes of Allergy and Infectious Diseases, NIH, USA) and Marsha Wills-Karp (Johns Hopkins Bloomberg School of Public Health, USA)
9:00 am - 9:10 amGerald Nepom (Benaroya Research Institute, USA)
"In Pursuit of Immune Tolerance: Perspectives from the Immune Tolerance Network"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amCarla Davis (Baylor College of Medicine, USA)
"Prevention of Symptoms with Oral Immunotherapy: What Is the Dose Threshold?"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amCorinne Keet (Johns Hopkins School of Medicine, USA)
"Practical Aspects of Early Peanut Introduction: Who Needs to Be Screened and How?"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amCecilia Berin (Icahn School of Medicine at Mount Sinai, USA)
"Mechanisms of Sensitization and Tolerance to Foods Through the Skin"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amYasmine Belkaid (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Microbiota Control of Tissue Homeostasis and Inflammation"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amCathryn Nagler (The University of Chicago, USA)
"Regulation of Allergic Responses to Food by Commensal Bacteria"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amGregory Sonnenberg (Weill Cornell Medicine, USA)
"Innate Lymphoid Cell (ILC) Regulation of Host-Microbe Interactions"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amRuchi Gupta (Northwestern University, USA)
"Early Diet and Environment's Impact on Microbiome and the Development of Allergies"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmKathy McCoy (University of Calgary, Canada)
"The Interplay Between the Gut Microbiota and Food Allergy"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmDaniel Mucida (The Rockefeller University, USA)
"Tissue Adaptation: Implications for Gut Immunity and Tolerance"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein and Peptide Chemistry Involved in Food Allergy
Discussion Leader: Holden Maecker (Stanford University School of Medicine, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader: Probing the Immune Response in Food Allergy Using CyTOF
7:45 pm - 7:55 pmBjoern Peters (La Jolla Institute for Allergy and Immunology, USA)
"Mapping Epitope Targets of T Cells in Food Allergy"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmMichael Angelo (Stanford University School of Medicine, USA)
"Highly Multiplexed Analysis of Resident and Inflammatory Immune Cell Populations Using Multiplexed Ion Beam Imaging"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmAnna Pomes (INDOOR Biotechnologies, USA)
"Food Allergens: A Molecular Perspective"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmPhilip Johnson (University of Nebraska-Lincoln, USA)
"Using Proteomics to Investigate Allergen Epithelial Transport and Subsequent Sensitization and Elicitation"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmRonald Rabin (U.S. Food and Drug Administration, USA)
"Mass Spectrometry to Complement Standardization of Complex Allergenic Extracts"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMagnus Borres (Uppsala University, Sweden)
"The Role of 2S Albumins in Food Allergy"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Role of B Cells and Immunoglobulins in Food Allergy
Discussion Leaders: Wesley Burks (University of North Carolina School of Medicine, USA) and Marcella Ruddy (Regeneron Pharmaceuticals, Inc., USA)
9:00 am - 9:20 amMubeccel Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland)
"Induction and Breaking of Allergen Tolerance, Role of T and B Regulatory Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amDuane Wesemann (Brigham and Women's Hospital / Harvard Medical School, USA)
"Regulation of IgE B Cells"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amThomas Platts-Mills (University of Virginia, USA)
"Can Specific IgE and IgG4 Responses Help to Explain the Increases in Food Allergy?"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amScott Boyd (Stanford University School of Medicine, USA)
"Analysis of B Cell Repertoires in Peanut Allergy"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amWayne Shreffler (Massachusetts General Hospital / Harvard Medical School, USA)
"Analysis of Antigen-Specific Repertoire in Relation to Peanut Allergy Phenotypes"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amTheodore Jardetzky (Stanford University, USA)
"Inhibition of IgE: Receptor Interactions and Signaling"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMaria Curotto de Lafaille (New York University School of Medicine, USA)
"IgG1 Memory Cells Keep the Memory of IgE Responses"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMotohiro Ebisawa (Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Japan)
"The Roles of IgE in Food Allergy"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmThe Roles of Basophils, Eosinophils, and Mast Cells in Food Allergy
Discussion Leaders: Stephen Galli (Stanford University School of Medicine, USA) and Hans Oettgen (Boston Children's Hospital / Harvard Medical School, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader: Deciphering the Roles of Mast Cells and Basophils in Food Allergy and Anaphylaxis
7:45 pm - 7:55 pmToshiaki Kawakami (La Jolla Institute for Allergy and Immunology, USA)
"Histamine-Releasing Factor Amplifies Intestinal Inflammation in Food Allergy"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmDonald MacGlashan (The Johns Hopkins University School of Medicine, USA)
"Terminating Mediator Release from Human Basophils and Mast Cells"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmBruce Bochner (Northwestern University, USA)
"Novel Strategies to Prevent Mast Cell Activation in Anaphylaxis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmYui-Hsi Wang (Sanofi, USA)
"IL-4 Signaling and IL-9-Producing Mucosal Mast Cells in Food Allergy"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmHans-Uwe Simon (University of Bern, USA)
"The Role of Eosinophils in Eosinophilic Esophagitis"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMarc Rothenberg (Cincinnati Children's Hospital Medical Center, USA)
"Deciphering the Immunological, Molecular and Genetic Components of the Food Allergy Disorder Eosinophilic Esophagitis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Role of the Epithelium in Allergic Disease
Discussion Leader: Rosemarie Dekruyff (Stanford University School of Medicine, USA)
9:00 am - 9:20 amCezmi Akdis (Swiss Institute of Allergy and Asthma Research, Switzerland)
"Role of Epithelial Barrier and Allergic Diseases"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amSimon Hogan (Cincinnati Children's Hospital Medical Center, USA)
"Intestinal Epithelial Allergen Sampling and Food Allergy"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amMoshe Biton (Broad Institute of MIT and Harvard, USA)
"Crosstalk Between Intestinal Stem Cells and Immune Cells Modulate Epithelial Cell Fate"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amMarsha Wills-Karp (Johns Hopkins Bloomberg School of Public Health, USA)
"Regulation of IL-33 by Dectin-1"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amSteven Ziegler (Benaroya Research Institute, USA)
"Regulation of Type-2 Immunity and Inflammation"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amMark Davis (Stanford University School of Medicine, USA)
"Immune Dysregulation in Humans and Mice"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Phenotypes and Endotypes in Food Allergy
Discussion Leader: Antonella Muraro (Padua General University Hospital, Italy)
7:30 pm - 8:00 pmGeorge Yancopoulos (Regeneron Pharmaceuticals, Inc., USA)
"History of Dupilumab"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmJonathan Spergel (Children's Hospital of Philadelphia, USA)
"Food Allergies: Phenotypes: IgE or Not? Endotypes: Anaphylaxis or Not?"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmRudolf Valenta (Medical University of Vienna, Austria)
"Molecular Allergology in Diagnosis, Treatment and Prevention of Food Allergy"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmR. Sharon Chinthrajah (Stanford University School of Medicine, USA)
"Mechanistic Clues to What Makes Oral Immunotherapy Work"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJames Baker (Food Allergy Research and Education (FARE), USA)
"Mucosal Immune Redirection in Food Allergy"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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