SESSION I: SUNDAY (P.M.), JUNE 8, 1997
CONTROL OF RECEPTOR FUNCTION
- 7:20 - Opening comments from site staff and Conference Chair
- 7:30 - Chair: Michael Freissmuth, University of Vienna
"The receptor - G protein interaction site: A potential drug target"
- 8:10 - Lee Limbird, Vanderbilt University Medical Center
"Role of the alpha2A AR in in vivo functions revealed by the D79N alpha2A AR mutant mouse"
- 8:45 - Michel Bouvier, University of Montreal
"Molecular mechanisms dictating signalling efficency of G protein-coupled receptors"
- 9:20 - Derrick Brazill, Rice University
"The signal transduction pathway of a eukaryotic cell density-sensing mechanism"
- 9:40 - Adjourn to pub for continued discussion
SESSION II: MONDAY (A.M.), JUNE 9, 1997
SUBCELLULAR ORGANIZATION OF SIGNALING COMPLEXES
- 9:00 - Chair: John Scott, Vollum Institite, University of Oregon
"Subcellular targeting of multi-enzyme signaling complexes"
- 9:40 - Tobias Meyer, Duke Univ. Medical center
"Localized signal transduction in mast cells"
- 10:15 - Coffee Break
- 10:40 - Jeremy Thorner, University of California, Berkeley
"Signal transmission, discrimination, and regulation in a yeast MAP kinase cascade"
- 11:15 - Morgan Sheng, Harvard Medical School - "Organization of signaling complexes by PDZ domain- containing proteins"
- 11:50 - Kendall Blumer, Washington Univ. Medical School
"Mechanism, modification and membrane targeting of RGS4, aGalpha-GAP"
- 12:10 - Mark Rasenick, University of Illinois, College of Medicine
"Regulation of cell form and teh cytoskeleton through G protein signals"
- 12:30 - Lunch
SESSION III: MONDAY (P.M.), JUNE 9, 1997
SIGNALING PROCESSES INVOLVING LIPID METABOLITES
- 7:30 - Chair: Sarah Spiegel, Georgetown University
"Sphingosine-I-Phosphate: A novel lipid second messenger in cell growth and apoptosis"
- 8:10 - John Exton, HHMI-Vanderbilt University Medical Center
"Role of Rho proteins in regulation of phospholipase D"
- 8:45 - Alex Toker, Boston Biomedical Research Institute
"Signaling via the lipid products of phosphoinositide 3-kinase"
- 9:20 - Katherine Hinchliffe, Cambridge University
"Multiple mechanisms of PI 4-P 5-kinase C regulation in human platelets"
- 9:40 - Adjourn to pub for continued discussion
SESSION IV: TUESDAY (A.M.), JUNE 10, 1997
CYTOKINE AND SENSORY SIGNALING SYSTEMS
- 9:00 - Chair: Neil Stahl, Regeneron Pharmaceuticals
"Modulation of STAT signaling by cytokine receptors and protein tyrosine phosphatases"
- 9:40 - Randall Reed, Johns Hopkins
"Specificity and Sensitivity in Olfactory Signaling"
- 10:15 - Coffee Break
- 10:40 - Cori Bargmann, Univeristy of California-San Francisco
"Olfactory recognition and signaling of C. elegans"
- 11:15 - Dawn Julifs, Univ. of Washington
"PDEs in olfaction"
- 11:35 - Michael Luther, Glaxo Wellcome
"Uncovering ligands for G protein-coupled receptors by analyzing the skin tone of frogs"
- 11:55 - Andre Chollet, Glaxo-Geneva Biomedical
"Mechanisms of chemokine signaling"
- 12:15 - James Inglese, Pharmacopeia
"Targeting the IL-8 receptor with combinatorial chemical libraries"
- 12:35 - Lunch
SESSION V: TUESDAY (P. M.), JUNE 10, 1997
REGULATION OF PROTEIN PHOSPHORYLATION STATUS
- 7:30 - Chair: Gary Johnson, National Jewish Center
"Regulation and function of MEK kinases"
- 8:00 - Jack Dixon, University of Michigan
"Protein tyrosine phosphatases in signal transduction"
- 8:45 - G. Stanley McKnight, University of Washington
"Selective disruption of dopaminergic pathways in PKA deficient mice"
- 9:20 - Alexander Pfeifer, Technische Universität München
"Mice deficient in cGMP-kinase I exhibit severe defect in aortic smooth muscle"
- 9:40 - Adjourn to pub for continued discussion
SESSION VI: WEDNESDAY (A.M.), JUNE 11, 1997
STRUCTURE AND FUNCTION OF G PROTEINS AND THEIR TARGETS
- 8:50 - Business Meeting - All attendees
- 9:00 - Chair: Ernest Peralta, Harvard University
"Molecular mechanisms of G control protein of ion channels"
- 9:40 - Heidi Hamm, University of Illinois
"G protein structure/function"
- 10:15 - Coffee Break
- 10:45 - Ronald Taussig, University of Michigan
"Regulation of adenylyl cyclases by G protein subunits"
- 11:20 - Patrick Casey, Duke University Medical Center
"G protein signaling/trafficking"
- 11:55 - Tohru Kataoka, Kobe University
"Isoprenylation-dependent and -independent interactions of Ras protein with its effectors"
- 12:30 - Lunch
SESSION VII: WEDNESDAY (P.M.), JUNE 11, 1997
CROSSTALK IN GTPase-MEDIATED SIGNALING
- 7:30 - Chair: Diane L. Barber, University of California-San Francisco
"GTPases, ion exchange and the actin cytoskeleton"
- 8:10 - Tatyana Voyno-Yasenetskaya, Univ. of Illinois
"Regulation of the ERK and JNK pathways by Galpha12 and Galpha13 proteins"
- 8:30 - Terry Snutch, Univ. of British Columbia
"Modulation of calcium channel activity: Crosstalk between PKC and G proteins"
- 9:05 - Vladen Slepak, Univ. of Miami School of Medicine
"Interaction of calcium binding proteins with GRKs"
- 9:20 - John Manfredi, Cadus Pharmaceutical Corporation
"Genetic selection of constitutively-active mammalian adenylyl cyclases in S. cerevisiae"
- 9:40 - Adjourn to pub for continued discussion
SESSION VIII: THURSDAY (A.M.), JUNE 12, 1997
PARADIGMS IN CELLULAR SIGNALING
- 9:00 - Chair: Melvin Simon, CalTech
- 9:05 - Stefan Offermans, Frei University Berlin
"Genetic approaches to the analysis of G protein function"
- 9:40 - Eva Neer, Harvard Medical School
"Molecular and genetic studies of G protein subunits"
- 10:15 - Coffee Break
- 10:45 - Robert J. Lefkowitz, Duke University Medical Center
"G protein-coupled receptors and their regulation"
- 11:20 - Joseph Beavo, University of Washington
"Different phosphodiesterase isozymes modulate distinct physiological responses"
- 11:55 - Lutz Birnbaumer, University of California-Los Angeles
"On the molecular basis and regulation of Capacitative Calcium Entry (CCE)"
- 12:30 - Lunch
SESSION IX: THURSDAY (P. M.), JUNE 12, 1997
- 7:30 - KEYNOTE LECTURE: Alfred G. Gilman, Univ. of Texas Southwestern Medical Center
"G proteins and the control of adenylyl cyclase"
- 8:30 - Adjourn to pub for continued discussion
FRIDAY (A.M.), JUNE 13, 1997
- 8:45 - Bus departs for Logan airport
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