Evening

• 5:30-7:15 - Dinner
• 7:30-7:45 - Welcome
  • Terry Van Dyke, Chair
  • Rita Cutroni, Site Manager

Session I: Cell Cycle

• 7:45-7:55 - Overview - Ed Harlow
• 7:55-8:30 - Ed Harlow, Massachusetts General Hospital - "The Rb signalling pathway"
• 8:30-8:50 - Robert Duronio, University of North Carolina - "Genetic Analysis of E2F/DP Function in Drosophila"
• 8:50-9:25 - Steve Ellege, Baylor College of Medicine - "Negative control of cell cycle transistions"
• 9:25-10:00 - Helen Piwnica-Worms, Washington University - "Reversible phosphorylation and mitotic control"

Morning

• 7:00-8:15 - Breakfast

Session II: Signal Transduction

• 8:30-8:40 - Overview - Channing Der
• 8:40-9:15 - Channing Der, University of North Carolina - "Increasing complexity of Ras signaling and transformation"
• 9:15-9:50 - Phil Soriano, Fred Hutchinson Cancer Research Center - "Tyrosine kinase signaling in mouse development"
• 9:50-10:25 - Jeff Wrana, The Hospital for Sick Children, Toronto - "Molecular basis for specificity in TGFß and BMP signalling"
• 10:25-11:10 - THE PORTRAIT, then Coffee
• 11:15-11:35 - Jeff Frost, UT Southwestern Medical Center - "Cross-cascade Regulation of the ERK Pathway by Rho Family Proteins"
• 11:35-12:10 - Michael Karin, University of California, San Diego - "Signalling pathways that control AP1 and NF-kB activities: A matter of life and death"
• 12:10-12:45 - Robert Kerbel, Sunnybrook Health Science Center, Univ. Toronto - "Oncogenes as inducers of tumor angiogenesis: Implications for signal transduction therapy of cancer"
• 12:50-1:50 - Lunch

Afternoon

• 4:00-6:00 - Poster Session I: Rocky Road of Signal Transduction

Evening

• 6:15-7:15 - Dinner

Session III: Regulation

• 7:30-7:40 - Overview - Sara Sukumar
• 7:40-8:15 - Sara Sukumar, Johns Hopkins Oncology Center - "HOX genes: novel markers of breast cancer progression"
• 8:15-8:35 - Nicole Screiber-Agus, Albert Einstein College of Medicine - "Role for the Myc antagonist Mxi1 in transcriptional and oncogenic repression in vivo"
• 8:35-9:10 - Marisa Bartolomei, University of Pennsylvania - "Molecular Control of Genomic Imprinting"
• 9:10-9:30 - Anindya Dutta, Harvard University - "Proteins involved in the initiation of DNA replication in human cells"
• 9:30-10:05 - Wade Harper, Baylor College of Medicine - "F-box protein dependent ubiquitination of cell cycle regulators by the skiposome"

Morning

• 7:00-9:00 - Breakfast

Session IV: Genome Integrity

• 9:15-9:25 - Overview - Thea Tlsty
• 9:25-10:00 - Thea Tlsty, University of California San Francisco - "Loss of genomic integrity in Preneoplastic cells"
• 10:00-10:35 - Tony Wynshaw-Boris, National Human Genome Research Institute - "Ataxia-telangiectasia: understanding the pleiotopic actions of Atm by modeling in the mouse."
• 10:35-10:50 - BREAK
• 10:50-11:25 - Manuel Perucho, The Burnham Institute - "Cancer of the microsatellite mutator phenotype"
• 11:25-12:00 - Titia DeLange, Rockefeller University - "Length control of human telomeres"
• 12:00-12:35 - Ron DePinho, Albert Einstein College of Medicine - "Role of Telomerase in the Development of Normal and Neoplastic Cells"
• 12:50-1:50 - Lunch

Evening

• 6:15-7:15 - Dinner

Session V: Tumor Suppressors

• 7:30-7:40 - Overview - Tyler Jacks
• 7:40-8:15 - Tyler Jacks, Massachusetts Institute of Technology - "Tumor Suppressor Gene Mutations in Mice"
• 8:15-8:50 - Scott Lowe, Cold Spring Harbor Laboratory - "Tumor suppressor gene action in chemosensitivity"
• 8:50-9:25 - Steve Baylin, Johns Hopkins Oncology Center - "Tumor specific patterns of gene inactivation associated with CpG island hypermethylation "
• 9:25-10:00 - William Kaelin, Dana Farber Cancer Institute - "Functional analysis of Von Hippel-Lindau protein"

Morning

• 7:00-9:00 - Breakfast

Session VI: p53 et. al.

• 9:15-9:25 - Overview - Carol Prives
• 9:25-10:00 - Carol Prives, Columbia University - "Signalling to p53"
• 10:00-10:35 - Arnold J. Levine, Princeton University - "The Role of p53 as an Integrator of the Signal Transduction Pathways That Lead to Cancer."
• 10:35-10:50 - BREAK
• 10:50-11:25 - Terry Van Dyke, University of North Carolina - "Elucidation of a p53 Tumor Suppression Pathway in Mice"
• 11:25-12:00 - Gigi Lozano, MD Anderson Cancer Center - "Dissection of the p53 Pathway in vivo"
• 12:00-12:35 - Jim Pipas , University of Pittsburgh - "SV40 T antigen functions as a DnaJ molecular chaperone in cellular transformation"
• 12:50-1:50 - Lunch

Afternoon

• 4:00-6:00 - Poster Session II: Cell Cycle and Gene Regulation in Neoplasia

Evening

• 6:15-7:15 - Dinner

Session VII: Human Genetics and New Technologies

• 7:30-7:40 - Overview - Joe Gray
• 7:40-8:15 - Joe Gray, University of California San Francisco - "Genome scanning in breast and ovarian cancer"
• 8:15-8:50 - David Mack, Affymetrix - "Profiling the cancer genome using high-density oligonucleotide arrays"
• 8:50-9:25 - John Weinstein, National Cancer Institute - "Information-intensivemolecular pharmacology: genomics, proteomics, and bioformatics"
• 9:25-10:00 - Ken Katz, National Cancer Institute - "The cancer genome anatomy project"

Morning

• 7:00-9:00 - Breakfast

Session VIII: Cancer Mechanisms and Tumor Progression

• 9:00-9:10 - Overview - Doug Hanahan
• 9:10-9:45 - Doug Hanahan, University of California San Francisco - "Pathways of tumorigenesis"
• 9:45-10:20 - Bruce Zetter, Harvard University - "Tumor Progression in Prostate Cancer".
• 10:20-10:35 - BREAK
• 10:35-11:10 - Norm Greenberg, Baylor College of Medicine - "TRAMP: A Transgenic Authochthonous Model for Progressive and Metastatic Prostate Cancer"
• 11:10-11:50 - Selected Short Talks
• 11:50-12:25 - Carlo Croce - "Genetics of Human Cancer"
• 12:50-1:50 - Lunch

Evening

• 6:15-7:15 - Dinner

Session IX: Gene Therapy and New Therapeutics

• 7:15-7:30 - Election of 1999 Chair (Vice-Chair 1998)
• 7:30-7:40 - Overview - R. Jude Samulski
• 7:40-8:15 - R. Jude Samulski, University of North Carolina - "Vector-targeted Gene Therapy: Model Systems and Clinical Promise"
• 8:15-8:50 - Laura Shawver, SUGEN, Inc. - "Tyrosine kinase inhibitors as cancer therapeutics - how specific should they be?"
• 8:50-9:25 - Drew Pardoll, Johns Hopkins University - "The New Generation of Molecularly Based Cancer Vaccines"
• 9:25-10:00 - Steven Eck, University of Pennsylvania - "Adenoviral vectors for cancer immunotherapy"
• 10:00 - Sara Sukumar, Vice Chair - Closing and Preview of 1998 Cancer Gordon Conference