Models for Metal Catalysis

Sunday evening

• Joan Valentine, Chair
• Lawrence Que, Jr. - Importance of the M₂O₂ Diamond Core in Stabilizing Higher Oxidation States in Non-heme Enzymes
• James Mayer - Understanding Hydrogen Atom Abstraction by Metal-Oxo and Coordination Compounds

Designing Proteins with Metal Sites

Monday morning

• Grant Mauk, Chair
• William DeGrado - Incorporating Metal Sites into Helical Bundles
• Lynne Regan - Novel Metal-Binding Proteins by Design
• Jay Winkler - Electron Transfer in Alpha Helices and Beta Sheets
• Andrew Borovik - Designing Metal Sites in Porous Organic Hosts

Molybdenum Oxidases and Reductases

Monday evening

• John Enemark, Chair
• Douglas Rees - Structures of Aldehyde Oxidoreductase and DMSO Reductase
• Charles Young - Models for Molybdopterins
• Raymond Stevens - SBIC Award Poster: Structure of Tyrosine Hydroxylase

CopperOxidases

Tuesday morning

• Hans Freeman, Chair - Short Talk on Crystal Structures of Amine Oxidases
• David Dooley - Spectroscopic and Crystallographic Models for the Active Sites of Amine Oxidases
• Judith Klinman - Cofactor Biogenesis and Catalysis in Copper Amine Oxidases
• Kenneth Karlin - Copper-Dioxygen Reactivity and Modeling of Heme-Copper Oxidases
• Gerard Canters - Magnetic Resonance of Dinuclear Copper Centers in Proteins

Manganese Oxidases

Tuesday evening

• Roman Czernuszewicz, Chair
• Michael Gold - Manganese Peroxidase: Expression, Structure, and Function
• James Whittaker - Manganese Redox Enzymes: Superoxide Dismutase and Catalase
• Vladimir barynin - SBIC Award Poster: Structure of Dimanganese Catalase at 1.6-Å Resolution

Metals and Gene Regulation

Wednesday morning

• Daniel Kosman, Chair
• Anne Summers - Metabolizing Mercury
• Dennis Winge - Metal Sensors That Mediate Copper Regulation of Gene Expression
• Valeria Culotta - Copper Ions and Protection Against Oxidative Stress
• Andrew Dancis - Intersecting Pathways for Iron and Copper Uptake in Yeast

Metalloenzymes in Bioremediation

Wednesday evening

• Robert Hausinger, Chair
• Lawrence Wackett - Assembling New Enzymatic Pathways in Bacteria
• Brian Fox - Bioengineering Diiron Enzymes: Applications to Toluene Monooxygenase

Iron Oxidases

Thursday morning

• John Dawson, Chair
• Brian Hoffman - Structure of Enzyme Intermediates by ENDOR Spectroscopy
• Shelagh Ferguson-Miller - Proton and Electron Pathways in Cytochrome c Oxidase
• Paul Ortiz de Montellano - Structure and Mechanism of Heme Oxygenase
• David Goodin - Engineering Heme Peroxidase Function by Cavity Complementation

A Look to the Future

Thursday evening, joint session with Gordon Research Seminar

• James Fee, Chair
• David Dolphin - Photodynamic Therapy with Porphyrins. From Discovery, to the Clinic, to FDA Approval