| Sunday 7:30-9:00 pm |
Keynote Address |
- Stephen Friend (Rosetta InPharmatics, WA) - Functional Genomics and Anticancer Drug Discovery for the 21st Century
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| Monday 9:00 am-12:30 pm |
Functional Genomics |
Chair: David Mack (EOS Biotechnology, CA)
- Robert Strausberg (NCI, MD) - NCI Cancer Genome Anatomy Project
- Patrick Brown (Stanford, CA) - cDNA Array Based Discovery
- Victor Velculescu (Johns Hopkins, MD) - Serial Analysis of Gene Expression
|
| Monday 4:30-6:00 pm |
Computer Workshop I: Molecular Biology Databases |
Chair: Chris Leonard (NCBI, MD)
|
| Monday 7:30-9:15 pm |
Combinatorial Chemistry |
Chair: Robert Jackson (ChiroScience, UK)
- Alex Polinsky (Alanex, CA) - Combinatorial Drug Discovery
- Stuart Schreiber (Harvard, MA) - Using and Discovering Small Molecule Ligands in Chemical Genetic Research
|
| Tuesday 9:00 am-12:30pm |
The p53 pathway |
Chair: Scott Lowe (Cold Spring Harbor, NY)
- Carol Prives (Columbia, NY) - The Biological Impact of p53 Function
- Andrei Gudkov (Chicago, IL) - Cellular Factors Mediating Tumor Suppressor Function of p53
- Carlos Cordon-Cardo (Memorial Sloan Kettering, NY) - The Impact Of p53 Status On The Clinical Treatment Of Cancer
|
| Tuesday 4:30-6:00 pm |
Computer Workshop II: Molecular Pharmacology Databases |
Chair: Tim Myers (NCI, MD)
|
| Tuesday 7:30-9:15 pm |
The Ras Pathway |
Chair: George Prendergast (Wistar Institute, PA)
- Han-Mo Koo (NCI-FCRDC, MD) - The Ras Oncogene and Antineoplastic Agents
- Ivan Horak (Janssen Pharmaceutica, NJ) - Clinical Studies with Farnesyltransferase Inhibitors
|
| Wednesday 9:00 am-12:30pm |
Signal Transduction |
Chair: Ed Sausville (NCI, MD)
- Paul Workman (CRC, U.K) - Anticancer Targets in Signal Transduction: Prospects and Challenges
- Len Neckers (NCI, MD) - The Protein Chaperone Hsp90 as an Anticancer Target
- Avi Askenazi (Genentech Inc., CA) - Control of Apoptosis Signaling by the Apo2 Ligand
|
| Wednesday 4:30-6:00 pm |
NIH Grant Workshop |
Chairs: Mary Wolpert-DeFilippes (NCI/NIH) & Marcia Litwack (DRG/NIH)
|
| Wednesday 7:30-9:15 pm |
Clinical Trials |
Chair: Hilary Calvert (Newcastle, UK)
- David Newell (Newcastle University, UK) - Evolving Prospects for the Preclinical and Clinical Evaluation of Novel Anticancer Agents
- Susan Arbuck (NCI, MD) - Clinical Trial Design: The Challenge of Developing Useful Paradigms for a New Generation of Anticancer Agents
|
| Thursday 9:00 am-12:30pm |
Cell Cycle Control |
Chair: Helen Piwnica-Worms (Wash. Univ., MO)
- Steve Reed (Scripps Institute, CA) - Cell Cycle Regulation in Mammalian Cells
- Jens Eckstein (Mitotix, MA) - Cdc25 Phosphatases as Anticancer Targets
- Daniel Cahill (Johns Hopkins, MD) - Mitotic Checkpoint Abnormalities & Human Cancer
|
| Thursday 4:30-6:00 pm |
Poster Discussion |
Chairs: Neil Gibson (Bayer) & Annette Larsen (France)
|
| Thursday 7:30-9:15 pm |
Apoptosis |
Chair: Kapil Bhalla (Emory University, GA)
- Emad Alnemri (Thomas Jefferson, PA) - Late Breaking Short-Talk: Regulation of Caspase-9 and Apaf-1 Activation
- John Reed (Burnham Institute, CA) - Suppressors of Apoptosis: Mechanisms of Action
- Gabriel Nunez (University of Michigan, MI) - Regulatory Controls in Apoptosis
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