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Sunday July 5
- 2:00 - 6:00 PM Registration, Simon Center
- 6:00 - 7:00 Dinner, Gilmore Hall
EVENING SESSION
Discussion Leader: Nigel Walshe - Pfizer, Inc.
- 7:30 Welcome, Steve Davidsen, Larry Roberts and Bill Carr
- 7:50 David Gin - University of Illinois, Urbana-Champaign - "Activated Sulfoxide Reagents in Glycosidic Coupling"
- 8:10 Clare Gutteridge - Columbia University - "A Total Synthesis of the Cytotoxic Marine Natural product Eleurherobin"
- 8:30 Barry Trost - Stanford University - "On the Invention of New Reactions in the Service of the Synthesis of Natural products"
- 9:30 Reception, Simon Center
Monday July 6
- 6:30 - 8:30 AM Breakfast, Gilmore Hall
MORNING SESSION
Discussion Leader: James McAlpine - Phytera
- 8:30 May Lee - Microcide Pharmaceuticals - "Chemical Diversity from Microbial Diversity"
- 9:20 Stephen Hitchcock - Eli Lilly and Company - "The Total Synthesis of Bacterial Cell Wall Precursors.- Implications for Antibacterial Drug Discovery"
- 9:40 Seiichi Matsuda - Rice University - "Generating Triterpene Diversity with Mutant Oxidosqualene Cyclases"
- 10:00 Break
- 10:30 Phil Crews - University of California, Santa Cruz - "Discovering Tools for Bioorganic Chemistry from the Constituents of Marine Sponges and Their Associated Microorganisms"
- 11:30 May Berenbaum - University of Illinois, Urbana-Champaign - "Chemists with Chlorophyll: Plants and Secondary Metabolites"
- 12:30 - 1:30 PM Lunch, Gilmore Hall
- 4:30 - 6:30 Poster Session #1, Simon Center
- 6:00 - 7:00 Dinner, Gilmore Hall
EVENING SESSION
Discussion Leader: David Gin - University of Illinois, Urbana-Champaign
- 7:30 Scott Rychnovsky - University of California, Irvine - "New Methods for Polyol Synthesis"
- 8:20 James Balkovec - Merck Research Laboratories - "Natural Born Killers.- Novel Antifungal Antibiotics"
- 9:00 Stephen Martin - University of Texas at Austin - "Recent Advances in the Total Synthesis of Heterocyclic Natural Products"
Tuesday July 7
- 6:30 - 8:30 AM Breakfast, Gilmore Hall
MORNING SESSION
Discussion Leader: Dee Ann Casteel - Bucknell University
- 8:30 Jon Clardy - Cornell University - "Natural Products and Their Macromolecular Receptors"
- 9:20 Spencer Knapp - Rutgers University - "Photosystem Special Pair Models"
- 9:40 Break - Group Photo Session
- 10:10 Ellen Baxter - R.W. Johnson Pharmaceutical Research Institute - "Arylsulfonate Esters in Solid Phase Organic Synthesis"
- 10:30 Laura Kiessling - University of Wisconsin, Madison - "Modulating Protein - Saccharide Interactions with Synthetic Ligands"
- 11:30 Robert Williams - Colorado State University - "Natural Product Synthesis as a Probe for Studying Biosynthesis and Biomechanisms"
- 12:30 - 1:30 PM Lunch, Gilmore Hall
- 4:30 - 6:00 Poster Session #2, Simon Center
- 6:00 - 7:00 Dinner, Gilmore Hall
EVENING SESSION
Discussion Leader: Sefichi Matsuda - Rice University
- 7:30 Ronald Parry - Rice University - "Genetic and En2ymological Investigations of Natural Product Biosynthesis"
- 8:20 Richard Baltz - DowElanco - "Molecular Genetics of Secondary Metabolite Biosynthesis.- Industrial Applications"
- 9:00 Chaitan Khosla - Stanford University - "Manipulating the Structure and Function of Natural Products using Genetic Engineering"
Wednesday July 8
- 6:30 - 8:30 AM Breakfast, Gilmore Hall
MORNING SESSION
Discussion Leader: Shelli McAlpine - Harvard University
- 8:30 Nicole Sampson - State University of New York, Stony Brook - "Peptide Inhibitors of Fertilization: Identification of a Target Receptor"
- 9:20 Richard Taylor - University of Notre Dame - "Conformational Libraries.- Modulation of the Biological Activity of Complex Natural Products"
- 9.40 Frederick Luzzio - University of Louisville - "Enzymatic Desymmetrization of meso-Azaspirocyclic Systems A Formal Route to (+) and (-)-Perhydrohistrionicotoxin
- 10:00 Break
- Robin Cooper - Cooper Consulting - "Bacterial Resistance.- The Andromeda Strain is Alive and Well"
- 11:10 Jun Liu - Massachusetts Institute of Technology - "Inhibition of Methionine Aminopeptidase 2 by the Angiogenesis Inhibitors TNP-470 and Ovalicin"
- 11:30 Craig Crews - Yale University - "Anti-angiogenic Natural Products and Cell Cycle Regulation"
- 12:30 - 1:30 PM Lunch, Gilmore Hall
- 4:30 - 6:00 Poster Session #3, Simon Center
- 7:00 Dinner, Gilmore Hall
EVENING SESSION
Discussion Leader: Larry Klein - Abbott Laboratories
- 7:30 Marco Ciufolini - University Claude Bernard Lyon - "Synthetic Studies on Heterocyclic Natural Products"
- 8:20 William Christ - Eisai Research Institute - "Synthetic Endotoxin Antagonists"
- 9.00 Tohru Fukuyama - University of Tokyo - "Synthetic Studies on Heterocyclic Natural Products"
Thursday July 9
- 6:30 - 8:30 AM Breakfast, Gilmore Hall
Discussion Leader: Robert Webb - MetaXen, LLC
- 8:30 Peter Beak - University of Illinois, Urbana-Champaign - "Enantioselective Reactions, Convenient Syntheses and Reaction Pathways"
- 9:20 Matthew Shair - Harvard University - "Two-Step Synthesis of the Core Structure of CP-225,91 7 Inspired by Biosynthesis"
- 9:40 Peter Maligres - Merck Research Laboratories - "Preparation of (S)-3-Carboxyethyl-3-benzylpiperidine and the Growth Hormone Secretagogue L-163,540"
- 10:00 Break
- 10:30 Nouri Neamati - National Institute of Health - "Design and Discovery of HIV-1 Integrase Inhibitors"
- 11:10 Patrick Lam - DuPont Merck Pharmaceuticals - "New Aryl/Heteroaryl C-N Bond Cross-coupling Reactions Via Copper-Promoted Arylation Using Arylboronic Acid"
- 11:30 William Roush - University of Michigan - "Recent Progress in the Total Synthesis of Natural Products"
- 12:30 - 1:30 PM Lunch, Gilmore Hall
- 2:00 - 4:00 Academic vs. Industrial Softball Game, Danheiser Memorial Softball Field
- 6:00 - 7:00 Dinner, Gilmore Hall
- 7:30 Business Meeting
EVENING SESSION
Discussion Leader: Matthew Shair - Harvard University
- 7:50 Michael Calter - Virginia Tech University - "One-Pot, Catalytic, Asymmetric Syntheses of All Four Stereoisomers of a Dipropionate Synthon"
- 8:10 Philip DeShong - University of Maryland, College Park - "Stereoselective Phenylation of Allylic Alcohol Derivatives by Palladium-Catalyzed Cross-Coupling with hypervalent Silicon Complexes"
- 8:30 David Evans - Harvard University - "Studies in Natural Products Synthesis"
- 9:30 Reception
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