Sunday evening, June 14
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7:30 pm: Welcome and introduction by the co-chairs
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Proteins That Bind Nucleic Acids
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7:45 pm: Linda Jen-Jacobson, University of Pittsburgh (Session
Chair)
Thermodynamic Signatures of
Specific and Nonspecific Protein-DNA Complexes
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8:30 pm: Kathleen Hall, Washington University
Describing RNA:protein recognition
with thermodynamics and NMR dynamics
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9:05 pm: Break
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9:35 pm: Donald Senear, University of California
Balance of Protein-protein and
Protein-DNA Energetics in Cooperative Assembly of Transcription Complexes
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10:10 pm: Gabriel Waksman, Washington University
Structure-function relationships
in dimeric DNA-helicases
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10:45 pm: Adjourn for informal discussion
Monday, June 15
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8:30 am: Conference Photograph
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Macromolecular Folding (Proteins)
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9:00 am: Ken Dill, University of California (Session Chair)
Modeling Conformations and Transitions
in RNA and Proteins
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9:45 am: David Baker, University of Washington
From folding kinetics
to protein structure prediction
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10:30 am: Break
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11:00 am: Michael Hecht, Princeton University
De Novo Proteins From Designed
Combinatorial Libraries
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11:45 am: Denis Rousseau, Albert Einstein College of Medicine
Folding Intermediates in Cytochrome
c
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12:30 pm: Adjourn for lunch
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Macromolecular Folding (RNA)
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7:30 pm: Anna Marie Pyle, Columbia University (Session Chair)
A link between conformational
change and ribozyme specificity in group II introns
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8:15 pm: Sarah Woodson, University of Maryland
Fast and slow folding pathways
of self-splicing RNA
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8:50 pm: Break
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9:20 pm: Tao Pan, University of Chicago
Folding of a large ribozyme:
intermediates, kinetic traps and domains
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9:55 pm: Jamie Williamson, The Scripps Research
Institute
RNA Rights Activism: Banning
Cruel Kinetic Traps
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10:30 pm: Adjourn for informal discussion
Tuesday, June 16
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Water and Macromolecular Interactions
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8:45 am: Adrian Parsegian, National Institutes of Health
(Session Chair)
Measured formation/compaction
free energy and entropy of the sickle cell Hemoglobin gel
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9:30 am: D. Wayne Bolen, University of Texas Medical Center at
Galveston
Protein folding and the osmophobic
effect
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10:10 am: Break
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10:40 am: Michael Fried, Pennsylvania State University College
of Medicine
Roles of water in CAP-DNA
interactions
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11:20 am: R. Peter Rand, Brock University
Probing protein water with osmotic
stress - The examples of hexokinase activity and actin assembly
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12:00 pm: Kim Sharp, University of Pennsylvania
Water structure, the hydrophobic
effect and heat capacity changes
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12:40 pm: Adjourn for lunch
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Single Molecule Measurements
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7:30 pm: Carlos Bustamante, University of Oregon (Session
Chair)
Inducing mechanical folding
and unfolding transitions in globular proteins with single molecule manipulation
methods
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8:15 pm: David Keller, University of New Mexico
Kinetic-Stochastic Theory of
Molecular Machines
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8:50 pm: Break
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9:20 pm: Jeff Gelles, Brandeis University
Studying transcription one molecule
at a time
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9:55 pm: Shimon Weiss, Lawrence Berkeley Laboratory
Single Molecule Protein Dynamics
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10:30 pm: David Bensimon, Ecole Normale Superieure
Manipulating single supercoiled
DNA molecules: structure and function
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11:05 pm: Adjourn for informal discussion
Wednesday, June 17
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Nucleic Acid Structure and Ligand Binding
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8:30 am: Helen Berman, Rutgers University (Session Chair)
The roles of water in nucleic
acid ligand binding
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9:15 am: David Beveridge, Wesleyan University
Molecular Dynamics Studies of
DNA: Axis Bending and Conformational Transitions
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9:55 am: Loren Williams
The Structural Origins of DNA
Conformational Heterogeneity
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10:15 am: Break
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10:45 am: Juli Feigon, University of California
Ion Binding and Folding in DNA
and RNA
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11:25 am: Stephen Neidle, University of London
New structural insights into
minor groove drug-DNA recognition
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12:05 pm William G. Scott, University of Indiana
Crystallographic Snapshots of
Hammerhead Ribozyme Catalysis
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12:45 pm: Adjourn for lunch
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Modeling Macromolecules
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7:30 pm: Eric Westhof, IBMC-CNRS (Session Chair)
Simulations of RNAs : from modular
assembly to the binding of water, ions and ligand
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8:15 pm: Peter Kollman, University of California
Simulations on Proteins, Nucleic
Acids and Carbohydrates
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8:50 pm: Break
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9:20 am: Lynne Regan, Yale University
Designing proteins with novel
structures and activities
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9:55 am: Jeff Skolnick, The Scripps Research Institute
New methods for the prediction
of protein structure and function from sequence
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10:30 pm: Adjourn for informal discussion
Thursday, June
18
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Multi-component Protein-Nucleic Acid Complexes
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8:45 am: Joachim Frank, Wadsworth Center (Session Chair)
Structure and functional binding
behavior of the ribosome as explored by cryo-electron microscopy
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9:30 am: Seth Darst, Rockefeller University
Structural studies of E.
coli RNA polymerase
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10:10 am: Break
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10:40 am: Ruth Sperling, Hebrew University of Jerusalem
Large Nuclear Ribonucleoprotein
(lnRNP) particles, the natural pre-mRNA processing machinery
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11:20 am: Jonathan Widom, Northwestern University
Chromosome Structure and Gene
Regulation
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12:00 pm: Cynthia Wolberger, The Johns Hopkins University School
of Medicine
Structure of GABP alpha/beta:
An ETS domain-ankyrin repeat heterodimer bound to DNA
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12:40 pm: Adjourn for lunch
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Evening Session
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7:30 pm: Business Meeting
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8:00 pm: Keynote Address: David Draper, The Johns Hopkins University
Energetics of Folding RNA Tertiary
Structures
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9:30 pm: Adjourn for informal discussion
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