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Sunday, February 15th, 1998
Evening Session - 7:30- 9:15 pm - KEYNOTE SPEAKERS
- 7:30 pm Introductory Remarks and Welcome - Dan Rich and Barbara Imperiali
- 7:35 pm Catherine Strader (Schering Plough) - G Protein Coupled Receptors as Targets for Drug Discovery
- 8:25 pm Christopher T. Walsh (Harvard Medical School) - Enzymatic Studies on the Formation of Oxazole and Thiazole Rings in Peptide Natural Products
- Welcoming Reception - 9:15 pm (Sponsored by Polypeptide Laboratories Inc.)
Monday., February 16th, 1998
Morning Session 8:30 am - 12:15 pm - PEPTIDOMIMETICS
- 8:30 am Introductory remarks from GRC
Session Chair Steven Adams (Biogen)
- 8:45 am Steven Adams (Biogen) - Inhibitors of Integrin VLa4 Antiinflammatory Peptide Mimic
- 9:30 am Philip Sanderson (Merck) - Peptidomimetics Based on the Pyridone Acetamide Template: Efficacious, Orally Bioavailable Non-covalent Thrombin Inhibitors
- 10:15 am Neil Moss (Boehringer Ingleheim) - Peptidomimetic Inhibitors of Protein-Protein Interactions
- 11:00 am Coffee Break and Photograph
- 11:30 am Robert Scarborough (COR Therapeutics) - Specific Inhibitors of Factor Xa: Synthesis and Evaluation in Comparison toThrombin Inhibitors
- Lunch: 12:30 - 1:30 pm
Poster Session: 4:30 - 6:00 pm (Refreshments Sponsored by Peptides International)
Evening Session 7:15-9:30 PM - PEPTIDE ANTIBIOTICS
Session Chair Garland Marshall (Washington University, St. Louis)
- 7:15 pm Mohamed A. Marahiel (Marburg) - Biosynthesis and Design of Peptide Antibiotics on Protein Templates
- 8:00 pm Dudley H. Williams (Cambridge University) - Cooperativity in the Action of Vancomycin Group Antibiotics
- 8:45 pm Robert E. W. Hancock (University of British Columbia) - Designing Improved Cationic Antimicrobial Peptides for Therapeutic Use
Tuesday, February 17th, 1998
Morning Session 8:45 am-12:15 pm - PEPTIDYL POLYMERS FOR MATERIALS RESEARCH
Session Chair Greg Fields (Florida Atlantic University)
- 8:45 am David A. Tirrell (University of Massachusetts, Amherst) - Cellular Synthesis of Artificial Protein-Based Materials
- 9:30 am Dan W. Urry (University of Minnesota) - The Advantages and Challenges of Peptide-Based Biomaterials
- 10:15 am Coffee break
- 10:45 am Linda Griffith (MIT) - Surface Tethered Growth Factors
- 11:30 am James P. Tam (Vanderbilt University) - Biomimetic Peptide Synthesis in Aqueous Solution
- Lunch: 12:30 - 1:30 pm
Poster Session: 4:30-6:00 pm
Evening Session 7:15-9:25 - NOVEL SYNTHETIC AND ANALYTICAL METHODS
Session Chair George Barany (University of Minnesota)
- 7:15 pm Mark Kurth (UC Davis) - Solid Phase Organic Synthesis from a Small Molecule Perspective
- 8:00 pm Roland Wenger (Novartis) - Synthesis of New Water Soluble Cyclosporins whose Conformations in DMSO and Water have been Established by NMR
- 8:45 pm Stephen F. Brady (Merck Research Laboratories) - Co-application of Structure-Based Design and Rapid Multiple Analog Synthesis on Solid Support to Optimize Small-molecule Thrombin Inhibitors
- 9:05 pm Antonello Pessi (IRBM P. Angeletti) - Inhibition of NS3 Protease as a target for therapeutic intervention in Viral Hepatitis C
Wednesday, February 18th, 1998
Morning Session 8:45 am-11:50 pm - PROTEIN DESIGN
Session Chair Jim Wells (Genentech)
- 8:45 am Lynne Regan (Yale) Protein Design - Design of Peptides with Novel Structures and Activities
- 9:30 am Samuel H. Gellman (University of Wisconsin, Madison) - Heteropolymer Folding: Proteins and Beyond
- 10:15 am Coffee break (15 min)
- 10:45 am P. Les Dutton (Penn) - Design and Construction of Redox Protein Maquettes
- 11:30 am Kent Kirshenbaum (UCSF) - Chiral Peptoids: N-Substituted Glycine Heteropolymers with Secondary Structure
- Lunch: 12:15 - 1:15 pm
- 12:45 pm - Trip to The Getty Center, Los Angeles (tickets required)
Poster Session: 4:30-6:00 pm
Evening Session 7:15-9:15 pm
Session Chair Jean Chmielewski (Purdue)
- 7:15 pm Steven W. Fesik (Abbott Laboratories) - NMR as a Tool in Drug Research
- 8:10 pm Ronald Kim (Merck Research Laboratories) - Combinatorial Synthesis on Multivalent Supports
- 8:55 pm Carlos Garcia-Echeverria (Novartis) - Structure-based Design of Potent Phosphopeptide Antagonists of the SH2 Dbmain of Grb2
Thursday, February 19th, 1998
Morning Session 8:45 am-11:50 pm - PEPTIDES AND MEMBRANES
Session Chair Charles Deber (University of Toronto)
- 8:45 am Charles Deber (University of Toronto) - LIncoupling Peptide Helicity and Hydrophobicity
- 9:30 am Debra Kendall (Connecticut) - Synthetic Signal Peptides: Probes of Molecular Interactions During Membrane Translocation
- 10:15 am Coffee break
- 10:45 am Stephen H. White (Univ. California, Irvine) - Protein Folding in Membranes: Mechanism of Secondary Structure Formation
- 11:30 am Timothy Burkoth (University of Chicago) - Insights into the Fibrilogenesis of beta-Amyloid
- Lunch: 12:30 - 1:30 pm
Afternoon Session 3:30-5:00 pm - VINCENT DU VIGNEAUD AWARDS
du Vigneaud Award Presentations
- 3:30 pm Jim Wells (Genentech) - From Proteins to Peptides
- 4:15 pm Peter W. Schiller (University of Montreal) - New Approaches in the Design of Opioid Peptide Derived Analgesics
- Vincent du Vigneaud Reception - 5:00 pm (Sponsored by Bachem)
- Conference Banquet Dinner - 6:30 pm
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