Sunday August 15, evening |
Structural Control of Gene Expression |
7:30 P.M. - 10: P.M. |
Mina Bissell, Discussion Leader |
- Mina Bissell, Lawrence Berkeley National Lab, Berkeley, CA
"The structural basis of tissue specificity: dynamic reciprocity revisited".
- Jennifer Lippincott-Schwartz, NICHD/NIH.
"Cell cycle localization and dynamics of intracellular organelles".
- Gary Stein, U.Mass. Med. Center, Worcester, MA
"Intranuclear trafficking of transcription factors."
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Monday August 16, morning |
Integrins and Signaling |
9:00 A.M. - 12:00 P.M. |
Fiona Watt, Discussion Leader |
- Fiona Watt, Imperial Cancer Research Fund, London, UK
"How ß1 integrins and MAPK regulate stem cell fate in cultured human epidermis".
- Joan Brugge, Harvard Medical School, Boston, MA
"Integrin induced signaling pathways activated independent of actin polymerization and FAK".
- Rudy Juliano, UNC, Chapel Hill, NC.
"Integrin modulation of signaling by G-protein coupled receptors".
- Rick Assoian, U. Penn. Med. Center. Philadelphia, PA
"Effects of growth factors, a5ß1 integrin and cell spreading on G1 phase MAPK and cyclins".
- Linda Hansen, University of Minnesota, MN
Short Talk: "Regulation of hepatocyte cell cycle by type I collagen: Role of cyclin D1, cell shape and MAPK."
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Monday August 16, evening |
Rho GTPases, Cytoskeleton and Signal Transduction |
7:30 P.M. - 10:00 P.M. |
Martin Schwartz, Discussion Leader |
- Martin Schwartz, Scripps Research Institute, LaJolla, CA
"Rho family GTPases in integrin mediated signaling".
- Koso Kaibuchi, Nara Inst. of Technology, Ikoma, Japan
"Functions and signal transduction of Rho targets".
- Richard Treisman, Imperial Cancer Research Fund, London, UK
"Control of the SRF transcription factor by Rho-family GTPases".
- Josephine Adams, University College, London
"Role of fascin, GTPases and muskelin in cellular responses to thrombospondin-1"
- Bradford W. Ozanne, Beatson Institute for Cancer Research, Glasgow
Short Talk: "AP-1 regulates a multigenic invasion program."
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Tuesday August 17, Morning |
Cytoskeleton and mRNA Localization and Metabolism |
9:00 A.M. - 12:00 P.M. |
Robert Singer, Discussion Leader |
- Robert Singer, Albert Einstein College of Medicine, Bronx, NY
"Intracellular transport and localization of mRNA".
- Gary Bassell, Albert Einstein College of Medicine, Bronx, NY
"Targeting mRNAs to neuronal growth cones and spines".
- Tulle Hazelrigg, Columbia Univ. NY, NY
"Subcellular RNA Localization during Drosophila Oogenesis".
- Kimberly Mowry, Brown University, Providence, RI
"Cytoplasmic RNA Transport in Xenopus Oocytes"
- Yoshinori Kohwi, Lawrence Berkeley Lab, Berkeley, CA
Short Talk: "Neuronal RNA binding proteins in the Huntington's disease model mouse."
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Tuesday, August 17, Evening |
Chromatin Organization and Function |
7:30 P.M. - 10:00 P.M. |
Terumi Kohwi-Shigematsu, Discussion Leader |
- Terumi Kohwi-Shigematsu, Lawrence Berkeley National Lab, Berkeley, CA
"SATB1 in higher order chromatin structure, gene regulation and apoptosis."
- Gordon Hager, NCI/NIH, Bethesda, MD
"Intranuclear trafficking and gene targetting by nuclear/steroid receptors."
- Sharon Roth, Univ. Texas, MD Anderson Cancer Center, Houston, TX.
"Antagonism of repression by histone acetylation".
- Geoffrey Wahl, Salk Inst. La Jolla, CA
"Molecular dissection of mammalian replicators".
- Ronen Marmorstein, Wistar Institute, UPenn, PA
Short Talk: "Crystal Structure of the Tetrahymena GCN5/coenzyme A/histone H3 peptide ternary complex reveals the mechanisms of substrate binding and catalysis by a histone acetyltransferase."
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Wednesday, August 18, Morning |
Nuclear Matrix: Structural Considerations in the Regulation of Gene Expression |
9:00 A.M. - 12:00 P.M. |
Jeffrey Nickerson, Discussion Leader |
- Jeffrey Nickerson, U.Mass. Med. Center, Worcester, MA
"The architecture of nuclear RNA metabolism"
- Rudolf Jaenisch, M.I.T. Cambridge, MA
"Epigenetic regulation in mammals".
- Ronald Berezney, SUNY, Buffalo, NY
"Global Properties of Genomic Organization and Function"
- Peter Cook, Oxford, England
"The organization of transcription."
- Michael Mancini, Baylor College of Medicine, Houston, TX
Short Talk: "Nuclear matrix involvement in estrogen receptor alpha subnuclear organization: transcription and turnover."
- Sophie Lelievre, Lawrence Berkeley Lab, Berkeley, CA
Short Talk: "Nuclear-directed signaling in mammary gland acini."
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Wednesday, August 18, Evening |
Cell Structure and the Response to Stress |
7:00 P.M. - 10:00 P.M. |
Don Ingber, Discussion Leader |
- Don Ingber, Childrens Hospital, Harvard Medical School, Boston
"Mechanical control of cell shape and function".
- Richard Morimoto, Northwestern Univ. Chicago, Ill
"The heat shock response and the stress of misfolded proteins".
- David Levens, NCI/NIH, Bethesda, MD
"The role of DNA stress, topology and conformation in gene regulation".
- Alexander Bershadsky, Weizmann Inst. of Science, Rehovot, Israel
"Adhesion and tension: Role of cell contractility regulation in the assembly of focal adhesions and adherens junctions".
- James Cunningham, University of Michigan, MI
Short Talk: "Stretch-induced signaling in smooth muscle cells"
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Thursday, August 19, Morning |
Adhesion-mediated Signaling and Cancer |
9:00 A.M. - 12:00 P.M. |
Avri Ben-Ze'ev, Discussion Leader |
- Avri Ben-Ze'ev, Weizmann Inst. of Science, Rehovot, Israel
"The dual role of ß-catenin and plakoglobin in adhesion and signal transduction".
- Shoukat Dedhar, Univ. British Columbia, Canada
" Regulation of cell-cell adhesion and gene expression by the Integrin Linked Kinase (ILK)."
- Margaret Wheelock, Univ. of Toledo, Toledo, OH
"Cadherins influence the phenotype and behavior of human tumor cells".
- Jean Paul Thiery, CNRS-Institute Curie, Paris, France
"Integrins and cadherins in embryonic cell motility".
- Stephen Sugrue, Univ. Florida College of Medicine, Gainsville, FL
Short Talk: "A nuclear and IF-desmosome-associated protein, pinin"
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Thursday, August 19, Evening |
Intercellular Contact in Cell Growth and Embryonic Development |
7:30 P.M. - 10:00 P.M. |
Benjamin Geiger, Discussion Leader |
- Benjamin Geiger, Weizmann Inst. of Science, Rehovot, Israel
"Molecular and functional diversity of cell adhesions".
- Randall Moon, Howard Hughes Inst. Univ. Washington, Seattle, WA
"How microtubules lead to localized ß-catenin-mediated gene expression".
- Mark Peifer, UNC, Chapel Hill, NC
"Cell adhesion, signal transduction and cancer: the Armadillo connection".
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