Welcome : Gillian Murphy

• Wolfram Bode (Germany): The TIMPS: flexible frameworks for the interaction with different recognition sites.
• Ekaterina Morgunova (Sweden): Structural basis for proteolytic activation of proMMP 2 and its interactions with TIMP 2.
• Duanqing Pei: CA-MMP: a novel paradigm for MMP structure and function?

WELCOME PARTY

• Carl Blobel (USA): Biochemical characterisation of metalloproteinase-disintegrins and search for potential substrates
• Roy Black (USA): TACE: substrate specificity and regulation of cell surface residency.
• Elizabeth Arner (USA): Aggrecanase(s): Purification and characterisation.
• Luisa Iruela-Arispe: Metallospondins / ADAM-TS family members and angiogenesis.
• Tian Xu (USA): Structural and functional studies of the Kuz metalloproteinase in Drosophila develoment.

• Mary Mullins (USA): Genetic analysis of tolloid in dorsoventral patterning of the zebrafish embryo.

• Linda Johnson (USA) : The effect of species differences on stromelysin-1 inhibitor potency: how predictive are animal models of human disease?
• John Bird (UK): What is the appropriate selectivity for development of MMP inhibitors for therapeutic use?
• Rachel Humphrey (USA): BAY12-9566: clinical development update.
• David Shalinsky: AG3340, a potent MMP inhibitor in clinical trials for the therapy of cancer and age-related macular degeneration.

DISCUSSION

• Motoharu Seiki (Japan): Regulation of MT-MMPs on the cell surface.
• Joaquin Arribas (Spain): ProTGFalpha as a model of the biosynthesis and ectodomain shedding of cell surface transmembrane proteins.
• Erica Werner (USA): Role of Rho GTPases and radical oxygen species in MMP expression.
• William Parks (USA): Integrin-collagenase interactions during cell migration.
• Peter Brooks (USA): Proteolytic exposure of a cryptic domain of collagen IV regulates angiogenesis and tumor growth.

• Howard Crawford (USA): Control of matrilysin expression by catenins and associated factors.
• Milagros Balbin (Spain): Human collagenase-3 as a target of bone transcription factors.
• Constance Brinckerhoff (USA): Effects of a single nucleotide polymorphism on collagenase-1 gene expression

• Howard Welgus (USA): A role for MMPs in immune responses in vivo: stromelysin-1 is required for the acquisition of contact hypersensitivity and gelatinase B for its resolution.
• Paul Soloway (USA): Regulation of innate immunity by TIMP-1.
• Jonathan Barasch (USA): TIMP-2 in the two compartments of the developing kidney.

• Angus McQuibban: Yeast two-hybrid analysis identifies monocyte chemoattractant protein 3 (MCP-3) as a novel substrate for gelatinase A
• Michael Sarras: Identification and functional characterization of matrix metalloproteinases in morphogenesis and cell differentiation pathways; analysis of hydra and zebrafish as developmental models
• Stanley Zucker: Rapid trafficking of MT1-MMP to the cell surface regulates function
• Yun-Bo Shi: Contrasting expression profiles and distinct functions of MMPs during Xenopus development

• Kenn Holmbeck (USA): A mouse model for MT1-MMP deficiency
• Zena Werb (USA): The role of MMPs in angiogenesis during development
• Chunghee Cho (USA): ADAMs in reproduction.
• Rama Khokha (Canada): TIMPs and mammary physiology

• Lisa Coussens (USA): Gelatinase B/MMP 9 from inflammatory cells is a critical effector of epithelial carcinogenesis.
• Agnes Noel (Belgium): Role of stromal MMPs in primary tumor growth.
• Alain Colige (Belgium)/Darwin Prockop (USA): Procollagen N-proteinase and procollagen C-proteinase. New roles in biology and naturally occurring mutations in the N-proteinase.

• Andrew Newby (UK): TIMP-3 gene transfer causes apoptosis in vitro and in vivo.
• Jeanine D'Armiento (USA) : In vivo roles of MMPs in atherosclerosis.
• Loran Killar (USA): Inducible tissue selective expression of human MMP13 results in an articular cartilage degeneration in transgenic mice.

Keynote Lecture: Guy Salvesen (USA) : ' Apoptosis: Cellular Signalling by Proteolysis'

Business meeting