SUNDAY |
2:00-9:00pm | Arrival and Registration |
6pm | Dinner |
| Keynote Speaker |
7:30pm | R. Kramer (BMS) Welcome and Introduction |
7:45pm | Frank McCormick (USCF) "Cancer Therapy Based on Ras, Rb and p53" |
MONDAY |
7:30-8:30am | Breakfast |
8:35am | GRC Business |
| Cancer Pharmacogenomics |
8:45am | Chair: Nic Dracopoli (BMS) "Pharmacogenomic Applications in Oncology Drug Development" |
9:00am | William Gerald (MSKCC) "Alterations in Gene Expression during Androgen Ablation Therapy of Prostate Carcinoma" |
9:35am | Discussion |
10:00am | Picture and Coffee Break |
10:30am | Todd Golub (Dana-Farber) "Gene Expression Signatures of Cancer" |
11:05am | Discussion |
11:30am | Jeffrey Trent (NIH) "Genome-Wide Views of Cancer Using Expression Profiling" |
12:05am | Discussion |
12:30pm | Lunch |
4:30pm | POSTER SESSIONS |
6:00pm | Dinner |
| Tumor Host Interactions - Therapeutic Implications |
7:30pm | Chair: Beverly Teicher (Genzyme Corp) "Exploring the Role of Tumor Physiology and Stromal Interactions in Therapeutic Response" |
7:45pm | Lisa Coussens (UCSF) "Deconstructing the Matrix: MMPs and their Substrates Regulate Epithelial Carcinogenesis" |
8:20pm | Discussion |
8:45pm | Jeffrey Arbeit (UCSF) "Induction of Quiescent Hypervascularity by Gain of Epithelial HIF-la Function" |
9:20pm | Discussion |
TUESDAY |
7:30-8:30am | Breakfast |
| Prostate Cancer |
8:45am | Chair: Marco Gottardis (BMS) "Use of AR Molecular and Structural Biology cues to Design New Endocrine Therapies for Prostate Cancer" |
9:00am | Howard Scher (MSKCC) "Targeting the Androgen Receptor Signaling Axis in Castration Resistant Disease" |
9:35am | Discussion |
10:00am | Coffee Break |
10:30am | John Isaacs (Bunting-Blaustein) "Using the Biology of Prostate Cancer to Develop Targeted Therapy" |
11:05am | Discussion |
11:30am | Peter Nelson (Fred Hutchinson Cancer Research Ctr) "Utilizing the Prostate Transriptome to Characterize Mechanisms of Complementary and Alternative Prostate Cancer Therapies" |
12:05am | Discussion |
12:30pm | Lunch |
4:30pm | POSTER SESSIONS |
6:00pm | Dinner |
| Growth Factor Receptors and Kinase Inhibitors |
7:30pm | Chair: Edward Sausville (NCI) |
7:45pm | Jose Baselga (Vall d'Hebron University Hospital) "Targeting the Epidermal Growth Factor Receptor Family: Current Status and Challenges" |
8:20pm | Discussion |
8:45pm | Pamela Trail (Bayer) "Development of the Raf Kinase Inhibitor BAY-439006 for the Treatment of Cancer" |
9:20pm | Discussion |
WEDNESDAY |
7:30-8:30am | Breakfast |
| Targeting Tumor Suppressors |
8:45am | Chair: Michael Morin (Pfizer) "Therapies Targeting Tumor Suppressor Genes: Small Molecules, Big Viruses and the Space in Between" |
9:00am | William Kaelin (Dana Farber) "Therapeutic Approaches Based on Inactivation of Tumor Suppressor Genes: Lessons from RB1 and VHL" |
9:35am | Discussion |
10:00am | Nominations for Vice Chair for 2003
Coffee Break |
10:30am | Geoff Duyk (Exelixis) "Genetic Analysis of Tumor Suppressor Pathways: The Role of Pathway Analysis and Drug Discovery" |
11:05am | Discussion |
12:30pm | Lunch |
4:30pm | POSTER SESSIONS |
6:00pm | Dinner |
| Tubulin and Motor Proteins |
7:30pm | Chair: Ken Tew (Fox Chase) |
7:45pm | Kenneth Wood (Cytokinetics) "Mitotic Kinesin-Targeted Antitumor Agents" |
8:20pm | Discussion |
8:45pm | Paraskevi Giannakakou (Emory) "Role of Microtubules in p53 Intracellular Trafficking and Signaling: Therapeutic Implications" |
9:20pm | Discussion |
THURSDAY |
7:30-8:30am | Breakfast |
| Targeting Chaperones and the Cell Cycle |
8:45am | Chair: Kevin Webster (Aztra Zeneca) |
9:00am | Philipp Steiner (Millenium) "Proteasome Inhibition to Treat Cancer: Development of PS-341" |
9:35am | Discussion |
10:00am | Election of Vice Chair for 2003 Coffee Break |
10:30am | Neal Rosen (MSKCC) "The Hsp90 chaperone as a regulator of mitogenic signaling and potential therapeutic target for cancer" |
11:05am | Discussion |
11:30am | Nikolai Pavletich (MSKCC) "Ubiquitin-ligases in Cancer: a Structural Perspective" |
12:05am | Discussion |
12:30pm | Lunch |
1:30pm | PROGRAM COMMITTEE, Year 2003 Conference |
4:30pm | Presentation of Selected Posters |
6:00pm | Banquet |
| Regulatory Challenges for the Cancer Drugs of Tomorrow |
7:30pm | Chair: Susan Arbuck (BMS) |
7:45pm | Richard Pazdur (FDA) "Drug Regulations: Defining Success in a Changing Scientific Environment" |
8:20pm | Discussion |
8:45pm | Craig Henderson (UCSF) "Regulators and Drug Developers: Creation of a Collegial Partnership for the War on Cancer" |
9:20pm | Discussion |
| BOOGIE NIGHT |
FRIDAY |
7:30-8:30 | Breakfast |
9:00 | Conferees depart |