SUNDAY |
2:00 pm - 9:00 pm | Arrival and check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | OVARIAN CANCER |
| Discussion Leader: Robert Young (Fox Chase Cancer Center) |
7:40 pm | Sandra Orsulic (Harvard Medical School)
"Transgenic mouse models for molecular characterization of ovarian cancer" |
8:15 pm | Discussion |
8:40 pm | Gordon R. Whiteley (NCI Clinical Proteomics Reference Labs)
"Proteomics profiling tools for the diagnosis and treatment of ovarian cancer" |
9:15 pm | Discussion |
MONDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | APOPTOSIS |
| Discussion Leader: Caroline Dive (University of Manchester) |
9:10 am | David Vaux (The Walter and Eliza Institute of Medical Research) "IAPs as therapeutic targets?" |
9:45 am | Discussion |
10:10 am | Coffee Break |
10:30 am | Steve Fesik (Abbott Laboratories)
"Discovery of Bcl-XL inhibitors for the treatment of cancer" |
11:05 am | Discussion |
11:30 am | Marie Hardwick (Johns Hopkins University) "Programmed cell death in yeast and neurons" |
12:05 pm | Discussion |
12:45 pm | Lunch / Photo |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PROTEOMICS / FUNCTIONAL GENOMICS |
| Discussion Leader: Martin Brown (Stanford University) |
7:40 pm | Simon Boulton (Cancer Research UK, Clare Hall)
"Functional genomic analysis of the C. elegans DNA damage response" |
8:15 pm | Discussion |
8:40 pm | Michael Snyder (Yale University)
"Global analysis of genomes and proteomes" |
9:15 pm | Discussion |
TUESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CHAPERONES AND STRESS RESPONSE |
| Discussion Leader: Amato Giaccia (Stanford University) |
9:10 am | D. Lynn Kirkpatrick (ProlX Pharmaceuticals) "PX-47: a potent inhibitor of HIF-1α and antitumor agent" |
9:45 am | Discussion |
10:10 am | Coffee Break |
10:30 am | Luke Whitesell (University of Arizona)
"Heat shock response-guided anticancer drug discovery" |
11:05 am | Discussion |
11:30 am | Linda Hendershot (St. Jude Children's Research Hospital)
"The mammalian unfolded protein response and its effects on chemosensitivity?" |
12:05 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CELL CYCLE REGULATION |
| Discussion Leader: John Lazo (University of Pittsburgh) |
7:40 pm | Charles Sherr (St. Jude Children's Research Hospital)
"The Ink4a-Arf Network" |
8:15 pm | Discussion |
8:40 pm | Robert Jackson (Cyclacel, Ltd)
"CYC202 (R-roscovitine): clinical and preclinical update on a CDK inhibitor" |
9:15 pm | Discussion |
WEDNESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | KINASES AND INHIBITORS |
| Discussion Leader: Judith Sebolt-Leopold (Pfizer Global Research and Development) |
9:10 am | Steve Averbuch (AstraZeneca) "Beyond HER2: The Clinical Realities for EGFR and other tyrosine kinases" |
9:45 am | Discussion |
10:10 am | Coffee Break |
10:30 am | Heidi Lane (Novartis Pharma AG) "The rapamycin derivative RAD001 in oncology: from the laboratory to the patient" |
11:05 am | Discussion |
11:30 am | Hidenori Ichijo (University of Tokyo)
"Stress responses mediated by the ASK1-SAPK signals" |
12:05 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NUCLEAR ARCHITECTURE ANS CHROMATIN |
| Discussion Leader: Nancy Davidson (Johns Hopkins University) |
7:40 pm | Steve Baylin (Johns Hopkins University) "Reversal of epigenetically mediated gene silencing as a target for cancer prevention and therapy" |
8:15 pm | Discussion |
8:40 pm | Victoria Richon (Aton Pharma) "Development of Histone Deacetylase inhibitors" |
9:15 pm | Discussion |
THURSDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DNA TRANSACTIONS |
| Discussion Leader: Neil Osheroff (Vanderbilt University) |
9:10 am | Ian Hickson (University of Oxford)
"Combined actions of RecQ helicases and topo III in suppressing chromosomal instability" |
9:45 am | Discussion |
10:10 am | Coffee Break |
10:30 am | Stewart Shuman (Memorial Sloan-Kettering Cancer Center) "The case for DNA ligase as a target for antimicrobial and anticancer therapy" |
11:05 am | Discussion |
11:30 am | Alex Burgin (deCODE Genetics) "Structural Insights into the Mechanism of Topoisomerase I poisons" |
12:05 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Select Poster Presentations |
6:00 pm | Reception / Dinner |
8:00 pm - 9:00 pm | KEYNOTE ADDRESS |
8:00 pm - 9:00 pm | Sir David Lane (University of Dundee) "Drug discovery in the p53 pathway" |
FRIDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am | Departure |