SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
5:00 pm - 6:00 pm | Welcome Reception |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Glycogen Synthase Kinase 3ß Phosphorylation: Risks versus Benefits |
| Chair: Ruth Roberts (Astra Zeneca) |
| Discussion Leader: Ronald Tjalkens (Colorado State University) |
7:30 pm - 8:00 pm | Ana Martinez (NeuroPharma)
"Inhibitors of GSK3ß therapeutic potential in neurodegeneration" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Stuart Aaronson (Mount Sinai School of Medicine)
"The role of the wnt pathway and ß-catenin in human cancer" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Charles Ruegg (Eli Lilly)
"GSK3ß - risks and benefits" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemical Mechanisms of Xenobiotic Bioactivation and Toxicity |
| Chair: Gary Yost (University of Utah) |
| Discussion Leader: Ronald N. Hines (Medical College of Wisconsin) |
9:00 am - 9:40 am | Paul Hollenberg (University of Michigan)
"Metabolic activation of xenobiotics by human P450s: trapping of reactive intermediate" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Christopher Reilly (University of Utah)
"Use of capsaicin analogs to implicate a quinone methide as a mechanism-based inactivator of Cyp2E1" |
10:30 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Break |
11:00 am - 11:40 am | Sharon Murphy (University of Minnesota)
"Cytochrome P450 2A6 and P450 2A13 as catalysts of nicotine and 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK) metabolism" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:30 pm | Late Breaking Research: |
| Co-Chairs: Ronald N. Hines and Ronald Tjalkens |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
| Chair: Christopher Reilly (University of Utah) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ubiquitin Proteosome System |
| Chair: Elaine Faustman (University of Washington) |
| Discussion Leader: Trevor Archer (National Institute of Environmental Health Sciences) |
7:30 pm - 8:00 pm | Maria Almira Correia (University of California, San Francisco)
"Cytochrome P450 ubiquitination and degradation: Cellular aspects" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Richard Pollenz (University of South Florida)
"The ubiquitin proteasome system as a biological target in toxic responses and disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Azad Bonni (Harvard University Medical School)
"Cdh1-APC regulation of axonal growth" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transporters: Proteins of Emerging Importance in Xenobiotic Disposition and Toxicology |
| Chair: Jose Manautou (University of Connecticut) |
| Discussion Leader: Nathan Cherrington (University of Arizona) |
9:00 am - 9:40 am | Ronald Oude Elferink (Amsterdam Liver Center)
"Transporters and drug disposition. The value of knockout models" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Susan Cole (Queen's University, Ontario)
"Structure-function studies of the human drug and organic anion transporter, MRP1 (ABCC1)" |
10:30 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Break |
11:00 am - 11:40 am | Curtis Klaassen (University of Kansas Medical Center)
"Role of transcription factors in the regulation of hepatic transporters" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:30 pm | Late Breaking Research: |
| Co-Chairs: Trevor Archer and Nathan Cherrington |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
| Chair: Christopher Reilly (University of Utah) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mechanisms of Nucleocytoplasmic Trafficking |
| Chair: Richard S. Pollenz (University of South Florida) |
| Discussion Leader: Kenneth S. Ramos (University of Louisville) |
7:30 pm - 8:00 pm | Zhou Wang (University of Pittsburgh)
"Androgen receptor intracellular trafficking in prostrate cancer cells" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Walter Watson (Johns Hopkins University)
"Nuclear translocation of thioredoxin" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Donald DeFranco (University of Pittsburgh)
"Role of molecular chaperones in nuclear mobility and chromatin exchange of steroid receptors" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondrial-mediated Metabolic Diseases |
| Chair: Rick G. Schnellmann (Medical University of South Carolina) |
| Discussion Leader: Kevin Kerzee (RCC, Ltd.) |
9:00 am - 9:40 am | Matthew J. Longley (National Institute of Environmental Health Sciences)
"Mitochondrial mutagenesis" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Elaine Holmes (Imperial College, London)
"Mitochondrial metabonomics" |
10:30 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Break |
11:00 am - 11:40 am | Gerald S. Shadel (Yale University School of Medicine)
"Mitochondrial gene expression in pro-growth metabolic signaling and ataxia" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:30 pm | Late Breaking Research: |
| Co-Chairs: Rick G. Schnellmann and Kenneth S. Ramos |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
| Chair: David Williams (Oregon State University) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Fetal Basis of Adult Disease |
| Chair: Mary Walker (University of New Mexico) |
| Discussion Leader: Kevin Osteen (Vanderbilt University) |
7:30 pm - 8:00 pm | Mark Hanson (University of Southampton)
"Systems-based approach for understanding developmental origins of disease" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Gail S. Prins (University of Illinois, Chicago)
"Epigenetic basis for increased prostrate cancer susceptibility following developmental exposure to estradiol and bisphenol A" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Nasar Zawia (University of Rhode Island)
"The fetal basis of Alzheimer's disease" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | Cell-cell Interactions that Mediate Organ System Toxicity |
| Chair: Kim Boekelheide (Brown University) |
| Discussion Leader: Agnes Kane (Brown University) |
9:00 am - 9:40 am | Michael Aschner (Vanderbilt University)
"Cross talk between astrocytes and neurons modulates methylmercury neurotoxicity" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Sem Phan (University of Michigan)
"Interstitial-epithelium interactions in lung injury" |
10:30 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Break |
11:00 am - 11:40 am | John Richburg (University of Texas at Austin)
"Sertoli cell preservation of fertility by triggering germ cell apoptosis? An irony revealed by reproductive toxicants" |
10:40 am - 11:50 am | Discussion |
11:50 am - 12:30 pm | Late Breaking Research: |
| Co-Chairs: Agnes Kane and Kevin Osteen |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
| Chair: David Williams (Oregon State University) |
6:00 pm | Dinner |
7:30 pm - 8:30 pm | Keynote Speaker |
7:30 pm - 7:35 pm | Introduction: Charlene A. McQueen (University of Arizona) |
7:35 pm - 8:25 pm | Michael Gallo (Rutgers University)
"Chick Edema to Chic Enigma: 50 years of the Arylhydrocarbon Receptor" |
8:30 pm | Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |