SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
5:30 pm | Reception / Mixer |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Co-Chairs Robert S. Balaban (Bethesda) and Loranne Agius (Newcastle University) |
7:40 pm - 9:30 pm | MITOCHONDRIAL SYSTEMS BIOLOGY |
| Discussion Leader: Paul Brookes (University of Rochester) |
7:40 pm - 8:10 pm | Andrew Halestrap (University of Bristol) "Signaling to and from the mitochondria in ischaemic preconditioning" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Kieran Clarke (University of Oxford) "Mitochondrial metabolism in cardiovascular disease" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Paul Brookes (University of Rochester) "Modeling mitochondrial responses to oxygen tension" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | METABOLOMICS IN SYSTEMS BIOLOGY |
9:00 am - 9:10 am | Official Welcome / Introductory Comments: Bob Balaban and Loranne Agius |
9:10 am - 9:15 am | Discussion Leader: Douglas Kell (University of Manchester) |
9:15 am - 9:45 am | Serge Rezzi (Nestle, Lausanne) "Metabotyping and nutrimetabolomics: non-invasive approaches to predict individual human health trajectories" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Matej Oresic (Tech Res Centre Finland) "Reconstruction of lipid pathways at cellular and systems levels" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break / Group Photo |
11:05 am - 11:35 am | Marta Cascante (University of Barcelona) "The robust metabolic adaptations that enable tumor progression are potential targets for combination therapy" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Douglas Kell (University of Manchester) "Systems biology of community metabolic network reconstructions: principles, praxis and the role of transporters in drug uptake" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session Moderators: Paul Insel & Pedro Mendes |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | COMPARTMENTATION OF CELL SIGNALING |
7:30 pm - 7:35 pm | Discussion Leader: Paul Insel (University of California San Diego) |
7:35 pm - 8:05 pm | Dermot Cooper (University of Cambridge) "Organisation of cAMP microdomains" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Hemal Patel (UCSD) "Caveolae, caveolins and mitochondria: a subcellular symbiotic relationship" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Mary Kennedy (Caltech) "Compartmental signal transduction of dendritic spines" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | COMPUTATIONAL APPROACHES TO PROTEIN FOLDING, BINDING AND FUNCTION |
9:00 am - 9:05 am | Discussion Leader: Ruth Nussinov (NCI and Tel Aviv University) |
9:05 am - 9:35 am | Andrej Sali (UCSF) "Integrating diverse data for Structure Determination of Macromolecular Assemblies" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Rob Russell (EMBL) "Predicting and modelling protein-protein interactions: from large complexes to tiny peptides" |
10:20 am - 10:35 am | Discussion |
10:35 am - 10:50 am | Coffee Break |
10:55 am - 11:25 am | Janet Thornton (University of Cambridge) "Protein-Ligand Interactions" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Ruth Nussinov (NCI and Tel Aviv University) "Modeling Alzheimer Amyloid Conformations and toxic Ion Channels" |
12:10 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FUTURE TRENDS IN FLUORESCENCE MICROSCOPY |
7:30 pm - 7:40 pm | Discussion Leader: Simone Baltrusch (University of Hannover) |
7:40 pm - 8:05 pm | Alexander Egner (Max Planck Instiute, Gottingen) "Developments in fluorescence microscopy" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Jörg Wiedenmann (University of Southampton) "Development of novel fluorescent proteins" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Daniel Krüger (Olympus Soft Imaging Solutions, Germany) "Cytometric high content data analysis: techniques and perspectives" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENOMIC AND PROTEOMIC ANALYSIS |
9:00 am - 9:05 am | Discussion Leader: Pedro Mendes (University of Manchester) |
9:05 am - 9:35 am | Anna Kashina (University of Pennsylvannia) "Posttranslational protein arginylation as a general intracellular regulator" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Federico Katzen (Invitrogen) "Insertion of membrane proteins into discoidal membranes using a cell-free protein expression approach" |
10:15 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:55 am - 11:25 am | Bernhard Palsson (University of California - San Diego) "Systems biology of human metabolism: recent developments and applications in network reconstruction" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Andrzej Kierzek (University of Surrey) "Analysis of gene essentiality and expression programme in the context of genome scale metabolic networks of M. tuberculosis and S. coelicolor" |
12:10 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SUBCELLULAR ORGANIZATION OF CELL SIGNALLING EVENTS |
| Discussion Leader: Ron Lynch (University of Arizona) |
7:30 pm - 8:00 pm | Ron Lynch (University of Arizona) "Visualizing the subcellular organization of Ca2+ signalling pathways" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Edwin Moore (University of British Columbia) "Quantitative Analysis of Macromolecular Organization in Intact Cell Systems" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Lonny Levin (Cornell University) "Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | PROTEIN-PROTEIN INTERACTIONS |
9:00 am - 9:05 am | Discussion Leader: Carol Robinson (University of Cambridge) |
9:05 am - 9:40 am | Carol Robinson (Cambridge University) "Mass spectrometry: from nanodroplets to networks" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:25 am | Brenda Winkel (Virgina Tech) "Outside the fence: redefining the Arabidopsis flavonoid metabolon" |
10:25 am - 10:35 am | Discussion |
10:35 am - 10:55 am | Coffee Break |
10:55 am - 11:30 am | Tom Kirkwood (Newcastle University) "Systems Biology of age-related cellular deterioration" |
11:30 am - 11:40 am | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Formal Dinner Banquet |
7:50 pm - 8:20 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:20 pm - 9:30 pm | CELL SIGNALING |
8:20 pm - 8:30 pm | Discussion Leader: Steve Oliver (University of Cambridge) "Introduction" |
8:30 pm - 9:20 pm | John Scott (University of Washington) "Cell Signaling in Space and Time" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Departure |