14:00 - 23:00 Registration
18:00 - 19:00 Dinner
19:30 - 21:30 Tyrosine kinase receptor signaling
Joseph Schlessinger, NYU Medical Center, New York, USA:
"Cellular signaling by tyrosine phosphorylation" (Chair)
Tony Pawson, Samuel Lunenfeld Research Institute, Toronto, Canada:
"Modular signaling proteins in cell differentiation and migration"
Axel Ullrich, Max-Planck-Institut für Biochemie, Martinsried bei München, Germany:
"Metalloproteinases as mediators of EGFR transactivation signals"
07:30 - 08:30 Breakfast
08:45 Conference photo
09:00 - 12:30 Tyrosine kinases in cell growth and motility
Tony Hunter, The Salk Institute, San Diego, USA:
"Transmembrane signaling by protein-tyrosine kinases" (Chair)
Paolo Comoglio, Univ. of Torino, Italy:
"Scatter Factor and Semaphorin Receptors: a Gene Superfamily"
Rüdiger Klein, EMBL, Heidelberg, Germany:
"In vivo definition of the signaling network downstream of the receptors for HGF and BDNF"
Lars Rönnstrand, Ludwig Institute for Cancer Research, Uppsala, Sweden:
"Specific signaling through heteromeric PDGF receptor complexes"
Sara Courtneidge, SUGEN Inc., South San Francisco, USA:
"Tyrosine and serine/threonine kinases as novel therapeutic targets in cancer"
Alexander Sorkin, University of Colorado Health Sciences Center, Denver, USA:
"Visualization of EGF receptor interactions with Grb2 in endosomes of living cells by FRET microscopy" (short presentation)
12:30 - 13:30 Lunch
16:30 - 18:00 Poster session (A-L)
18:00 - 19:00 Dinner
19:30 - 21:30 Apoptotic signaling
Gerard Evan, University of California, San Francisco:
"Life and death signaling in cancer" (Chair)
Martin Schuler, La Jolla Institute for Allergy and Immunology, San Diego, USA:
"Death from within - regulation of the mitochondrial apoptotic pathway"
Andreas Bergman, Howard Hughes Medical Institute, Cambridge, USA:
"Regulation of cell number by MAPK-dependent control of apoptosis in Drosophila"
07:30 - 08:30 Breakfast
09:00 - 12:30 Intracellular signaling
Roger Davis, Univ. of Massachusetts, Worcester, USA:
"Signal transduction by stress-activated MAP kinases" (Chair)
Jacques Pouysségur, Université de Nice, Nice Cedex, France:
"MAP kinase signaling and angiogenesis"
Christopher Marshall, CRC Centre for Cell and Molecular Biology, London, U.K.:
"Small GTPases and the control of cell proliferation"
Anne Ridley, Ludwig Institute for Cancer Research, London, U.K.:
"Signalling, Rho GTPases, and cell migration"
Michael Karin, University of California at San Diego, La Jolla, USA:
"Control of Gene Expression by Proinflammatory Cytokines"
Jacques Dumont, Universite Libre de Bruxelles, Brussels, Belgium:
"The mechanism of TSH cAMP stimulating action and IGF1 permissive effect on thyroid cell proliferation" (short presentation)
12:30 - 13:30 Lunch
16:30 - 18:00 Poster session (A-L)
18:00 - 19:00 Dinner
19:30 - 21:30 Angiogenic factors
George Yancopoulos, Regeneron Pharmaceuticals, Inc., Tarrytown, USA:
"Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic angiogenesis" (Chair)
Hua Quan Miao, Harvard Medical School, Boston, USA:
"The role of neuropilin and their VEGF and semaphorin ligands in tumor angiogenesis"
Lena Claesson-Welsh, Uppsala University, Uppsala, Sweden:
"Molecular mechanisms in angiogenesis and anti-angiogenesis"
07:30 - 08:30 Breakfast
09:00 - 12:30 TGF-ß family members
Joan Massagué, Howard Hughes Medical Institute, New York, USA:
"How cells read TGF-ß signals" (Chair)
Jeffrey Wrana, Samuel Lunenfeld Research Institute, Toronto, Canada:
"TGF-ß signalling and the ubiquitin-proteasome system"
Rik Derynck, University of California, San Francisco, USA:
"Regulation of gene expression by Smads"
Peter ten Dijke, The Netherlands Cancer Institute, Amsterdam, The Netherlands:
"TGF-ß receptor signal transduction"
Anita Roberts, National Cancer Institute, Bethesda, USA:
"Smad3 - a key mediator of the pathogenetic effects of TGF-ß"
Kohei Miyazono, The Cancer Institute, Tokyo, Japan:
"TGF-ß signaling by Smads"
12:30 - 13:30 Lunch
16:30 - 18:00 Poster session (M-Z)
18:00 - 19:00 Dinner
19:30 - 21:30 Cytokine receptor signaling
James Ihle, Howard Hughes Medical Institute, Memphis, USA:
"Positive and Negative Regulators of Cytokine Signaling"
Jim Wells, Sunesis Pharmaceuticals, Inc., Redwood City, USA:
"Drug discovery for signaling molecules"
Douglas Hilton, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia:
"SOCS proteins: Negative regulators of cytokine signalling"
07:30 - 08:30 Breakfast
09:00 - 12:30 Growth factors in development
Per Lindahl, University of Gothenburg, Sweden:
"PDGF functions in vivo - lessons from knock out mice" (Chair)
Kari Alitalo, University of Helsinki, Finland:
"VEGFs and receptors regulating angiogenesis and lymphangiogenesis"
Gary Ruvkun, Harvard Medical School , Boston, USA:
"C. elegans insulin like signaling: the transcriptional outputs and action in the nervous system are key"
Biyung Hwang, Howard Hughes Medical Institute, Pasadena, USA:
"EGF signalling in C. Elegans development"
Norbert Perrimon, Harvard Medical School, Boston, USA:
"Role of glyosylation events in signaling"
Erwin Bottinger, Albert Einstein College of Medicine, Bronx, USA:
"An arrayed view of the TGF-ß response system" (short presentation)
12:30 - 13:30 Lunch
16:30 - 18:00 Poster session (M-Z)
18:00 - 19:00 Dinner
19:30 - 21:30 Wnt signaling
Mariann Bienz, MRC Laboratory of Molecular Biology, Cambridge, UK:
"Tumour suppressor signalling in Drosophila" (Chair)
Roel Nusse, Howard Hughes Medical Institute, Stanford, USA:
"Sorting out Wnt-Frizzled specificity in Drosophila"
Hans Clevers, University Hospital, Utrecht, The Netherlands:
"TCFs in Wnt signaling and cancer"
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