| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Trafficking and Dynamics of Growth Factor Receptors |
| Welcome: Roger Davis |
| Silvia Corvera, Chair |
| Philippe Bastiaens, European Molecular Biology Lab, Heidelberg
Imaging RTK/PTP cycles |
| Tomas Kirchhausen, Harvard Medical School
Structural insights into the mechanism of growth factor receptor endocytosis
|
| Silvia Corvera, UMASS Medical School
New insights on receptor dynamics obtained using Fast microscopy |
| 9:30 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | Neuronal Signaling Mechanisms |
| Tony Pawson, Chair |
| Michael Greenberg, Harvard Medical School
Signal transduction pathways that regulate differentiation and survival in the developing nervous system |
| Rudiger Klein, Max-Planck-Institut fur Neurobiologie, Martinsried
Tyrosine kinase receptor signaling during neural development |
| John Flanagan, Harvard Medical School
Axon guidance and neural MAP specification by ephrins |
| John Scott, HHMI & Vollum Insitute, OHSU
The molecular architecture of kinase phosphatase signaling complexes |
| Michael Karin, University of California, San Diego
Regulation of IKK activity and biological responses by members of TNF family |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Bio-informatics/Proteomics and Complex Systems |
| Jim Ferrell, Chair |
| Mike Tyers, Samuel Lunenfeld Research Institute, Toronto
Multi-site phosphorylation dependent protein interactions |
| Matthias Mann, University of Southern Denmark
Cytokine induced changes in global phosphorylation by proteomic methods |
| Gary Ruvkun, Massachusetts General Hospital
Biological roles of insulin and insulin-like growth factors |
| Jim Ferrell, Stanford University
Systems-level behavior of MAPK modules |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Growth Factor Signaling Mediated by G Proteins |
| J. Silvio Gutkind, Chair |
| Richard Cerione, Cornell University
Structure and function of Cdc42 |
| Johannes Bos, Utrecht University
Ras and Rap1 in cell proliferation and integrin-mediated adhesion |
| Richard Marais, Institute for Cancer Research, London
Raf kinase regulation |
| Deborah Morrison, NCI, NIH
Structural Insights into Protein Kinases |
| J. Silvio Gutkind, NIDR, NIH
MAP kinase regulation by Rho proteins |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | TGF-beta Family of Growth Factor Receptors |
| Caroline Hill, Imperial Cancer Research Fund, London |
| Jeff Wrana, Samuel Lunenfeld Research Institute, Toronto
TGF-ßeta signalling |
| Lan Xu, Memorial Sloan Kettering Institute
"Nucleocytoplasmic shuttling of Smad2 in TGFbeta signaling" |
| Caroline Hill, Imperial Cancer Research Fund, London
Signalling to the nucleus by TGF-ßeta superfamily members |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling by the Insulin Receptor |
| Michael Czech, Chair |
| C. Ronald Kahn, Joslin Diabetes Center
Analysis of conditional knockout mice with diabetes |
| George Thomas, Freidrich-Miescher Institute
Mammalian TOR: A homeostatic ATP sensor |
| Philip Cohen, University of Dundee
Signal transduction by the insulin receptor |
| Michael Czech, UMASS Medical School
Analysis of Insulin Signaling by Genomics and Gene Silencing |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | The Wnt Pathway |
| Jim Woodgett, Chair
|
| Roel Nusse, HHMI & Stanford University
Specificity of signaling by different Wnt proteins |
| Norbert Perrimon, HHMI & Harvard University
Regulation of cell development and polarity by protein kinases |
| Marek Mlodzik, Mount Sinai School of Medicine
Frizzled signaling and the establishment of planar cell polarity |
| Jim Woodgett, Ontario Cancer Institute , Toronto
Genetic analysis of PKB/AKT and GSK-3 signaling |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cytokine Signaling Networks |
| Sankar Ghosh, Chair |
| Doug Hilton, The Walter and Eliza Hall Institute of Medical Research
SOCS proteins - negative regulators of cytokine signal transduction |
| James Ihle, HHMI & St Judes Medical Center
Downstream events in cytokine signaling |
| Tony Pawson, Samuel Lunenfeld Research Institute, Toronto
Modular proteins in signal transduction |
| Len Zon, HHMI & Harvard Medical School
Signaling by cytokines in zebra fish development |
| Sankar Ghosh, HHMI & Yale University Medical School
Phosphorylation-dependent regulation of NF-kappaB transcriptional activity |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 - 9:30 pm | Apoptosis
|
| Craig Thompson, Chair |
| Jurg Tschopp, University of Lausanne
Death receptor signal transduction |
| Andreas Strasser, The Walter and Eliza Hall Institute of Medical Research
BH3 - only proteins are essential initiators of programmed cell death |
| Josef Penninger, Amgen Inc.
Elucidation of an AIF regulated cell death pathway |
| Craig Thompson, University of Pennsylvania
The mitochondial cell death pathway into growth factor mediated cell survival |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
