| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session |
| Tony Pawson (Chair) |
| Joan Brugge (Harvard University, Boston)
"Signaling and Breast Cancer" |
| John Kuriyan (University of California, Berkeley)
"Structural analysis of signaling complexes" |
| MONDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Kinases and Phosphatases |
| Liliana Attisano (Chair) |
| David Barford (Institute of Cancer Research, London)
"Structural studies of the B-RAF kinase, and basis for oncogenic activation" |
| Dario Alessi (University of Dundee)
"The PDK1/AKT signaling pathway" |
| Michael Yaffe (MIT, Boston)
"Phosphoserine/threonine binding domains" |
| Susan Taylor (University of California, San Diego)
"Signaling by PKA" |
| Louise Johnson (University of Oxford)
"Protein kinase substrate recognition" |
| Anne Ridley (Ludwig Inst. For Cancer Research, London)
"Signaling to the actin cytoskeleton" |
| 12:45 pm | Lunch / Photo |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Scaffolds |
| Michael Yaffe (Chair) |
| Deborah Morrison (NCI-FCRDC, Fredrick)
"KST and the MAP Kinase pathway" |
| Roger Davis (University of Massachusetts, Worcester)
"Signaling through MAP kinases" |
| Wendell Lim (University of California, San Francisco)
"Re-engineering signaling pathways" |
| John Scott (Oregon Health Science University, Portland)
"A-Kinase anchoring proteins" |
| TUESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Neuronal Signalling |
| John Scott (Chair) |
| John Flanagan (Harvard University, Boston)
"Cues for axon guidance and neural map development" |
| Frank Gertler (MIT, Boston)
"Dynamic regulation of neuronal growth cones" |
| Elke Stein (Yale, New Haven)
"Guidance receptors" |
| Dimitar Nikolov (Memorial Sloan-Kettering, New York)
"Structure of guidance molecules" |
| Morgan Sheng (MIT, Boston)
"Signaling at excitatory synapses" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Innate Immunity/Apoptosis |
| Roger Davis (Chair) |
| Julian Downward (London Research Institute, London)
"Ras signaling pathways in the control of apoptosis and transformation" |
| Richard Flavell (Yale University, New Haven)
"Signaling in innate immunity" |
| Brian Hemmings (Friedrich Mieschler Institute, Basel)
"Protein kinase B signaling" |
| Jurg Tschopp (University of Lausanne)
"The Stressosomes: Detecting intracellular danger" |
| WEDNESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | High throughput analysis and Modelling |
| Lewis Cantley (Chair) |
| Marc Vidal (Harvard University, Boston)
"HTP analysis of signaling in C. elegans" |
| Jeff Wrana (Samuel Lunenfeld Research Institute, Toronto)
"HTP mapping of dynamic signaling networks in mammalian cells" |
| Doug Lauffenburger (MIT, Boston)
"Cue-Signal-Response analysis of cell behavior functions" |
| James Ferrell (Stanford University)
"Ultrasensitive switches in signaling" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | TGF#223;/Development |
| Elke Stein (Chair) |
| Caroline Hill (London Research Institute, London)
"TGFß signaling" |
| Fiona Watt (London Research Institute, London)
"Signaling through cell-cell interactions" |
| Liliana Attisano (University of Toronto)
"Intersection of TGFß and Wnt signaling pathways" |
| THURSDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Kinase Networks |
| Susan Taylor (Chair) |
| Mark Lemmon (University of Pennsylvania, Philadelphia)
"EGF receptor activation and inhibition" |
| George Thomas (Friedrich Miescher-Institut)
"The mTOR/S6K Signaling Pathway in Development and Human Disease" |
| Lewis Cantley (Harvard University, Boston)
"PI3 kinase signaling pathways" |
| Morag Park (McGill University, Montreal)
"Kinases and epithelial-mesenchymal-like transitions" |
| Harald Stenmark (Norwegian Radium Hospital, Oslo)
"Regulation of endocytic and autophagic membrane traffic by PI 3-kinases" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Trafficking/Endocytosis |
| Tony Kourzarides (Chair) |
| Pier Paolo di Fiore (FIRC Institute of Molecular
Oncology Foundation, Milan)
"Monoubiquitination in endocytosis and signaling" |
| Chromatin Organization |
| Pier Giuseppe Pelicci (European Institute of Oncology, Milan)
"Chromatin Regulation and cancer" |
| Tony Kouzarides (Wellcome/CRUK Institute, Cambridge)
"Chromatin modifications in transcription and cancer" |
| FRIDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
