1500-1800h Reception, drinks and light snacks

1800h dinner

Session 1 Pineal molecular machinery
Discussion Leader: Carla Green

1930-1940h Introduction Carla Green

1940-2040h Keynote Speaker: David C. Klein
Melatonin switching: What's going on inside the cell?

2040-2120h Horst Korf
Comparative analyses reveal multiple control mechanisms of melatonin production.

2120-2200h David J. Kennaway
Melatonin, mice and the Clock gene.

Session 2 Phototransduction mechanisms
Discussion Leader: Mark Rollag

0900-0910h Introduction Mark Rollag

0910-0950h Yoshitaka Fukada
Photoentrainment and molecular cycle in pineal clock system

0950-1030h Russell Foster
Twilight detection: A role for complex and specialised photoreceptors

1030-1100h Coffee Break

1100-1140h Debra Skene
Spectral sensitivity of light-induced suppression of melatonin in humans

1140-1220h George Brainard
Action spectrum for melatonin regulation in humans

1245h Group Photo

1300 Lunch

Hot Topics, Cellular and molecular aspects.
1600-1800h 10minutes presentation plus 5 minutes discussion

1600-1615h Hannibal Jens, Vrang N, Card P, Fahrenkrug J.
Light dependent induction of c-Fos during subjective day and night in PACAP containing retinal ganglion cells constitute the retino-hypothalmic tract. Dept Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Denmark.

1615-1630h Garabette Martine, Reddy AB, Hastings MH.
Photoperiodic modulation of clock genes and clock proteins in the SCN

1630-1645h Kopp Michael DA, Schomerus C, Dehghani F, Korf H-W, Meissl H.
PACAP- and glutamate-induced calcium rises in SCN neurones. Max-Planck-Institut fur Hirnforschung, Frankfurt/M, Germany.

1645-1700h Okano Toshiyuki.
A BMAL2-CLOCK heterodimer is a positive regulator in a transcription/translation-based autoregulatory feedback loop of vertebrate clock systems. The University of Tokyo, Department of Biophysics and Biochemistry, Hongo 7-3-1, Bunkyo-Ku, Tokyo.

1700-1715h Tosini G. Fukuhara C. Doyle S. Geusz M. Menaker M.
Induction of photosensitivity in neonatal rat pineal. Neuroscience Institute, Morehouse school of Medicine, 720 Westview Drive, SW, Atlanta, GA 30310-1495, USA.

1715-1730h Scher Judy, Fujieda H, Wankiewicz, Brown GM.
Melatonin mt1 Receptor localization in human and guinea pig retina. Department of Physiology MSB, Rm 3321, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

1730-1745h Hayashi Mitsuko, Yatsushiro S, Morita M, Yamamoto A, Moriyama Y.
Glutamate receptor subunit d2 is highly expressed in a novel population of glial-like cells in rat pineal glands in culture. Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.

1745-1800h Ayoub MA, Angers S, Bouvier M, Jockers Ralf.
Oligomerization of melatonin receptors detected in living cells by Bioluminescence Resonance Energy Transfer (BRET). CNRS, UPR 415, ICGM, 22 rue Mechain, Paris, France.

1800h Dinner

Session 3 Melatonin targets
Discussion Leader: Liz Maywood

1930-1940h Introduction Liz Maywood

1940-2015h Margarita Dubocovich
New insights into the pharmacology and function of melatonin receptors

2015-2050h Sophie Messager
Clock genes: regulation of expression by photoperiod and melatonin.

2050-2125h David Weaver
Melatonin receptors and melatonin receptor deficient mice

2125-2200h Benoit Malpaux
Hypothalamic sites of action of melatonin to control seasonal reproduction in sheep

Session 4 Photoperiodic readout
Discussion Leader: Andrew Loudon

0900-0910h Introduction Andrew Loudon

9010-0950h Helen Illnerova
Photoperiodic modulation of rhythmicity of the mammalian SCN subdivisions

0950-1030h Thomas Wehr
Pineal expression of SCN signal of change of season in humans

1030-1100h Coffee Break

1100-1140h Gerald A. Lincoln
Reading melatonin signals in target tissues

1140-1220h Michael Menaker
How does light information reach the pineal?

1230h Lunch

Session 5 Circadian entrainment
Discussion Leader: Martha Gillette

1930-1940h Introduction Martha Gillette

1940-2015h Eberhard Gwinner
Circadian entrainment and melatonin: phasic versus tonic effects

2015-2050h Paul Pevet
Melatonin entrainment of circadian rhythms in rodents

2050-2125h Steven Lockley
Effects of melatonin on human free-running rhythms

2125-2200h Jenny Redman
Melatonin entrainment: is it species dependent?

Session 6 Clock mechanisms
Discussion Leader: Marty Zatz

0900-0910h Introduction Marty Zatz

0910-0950h Steven Reppert
Molecular control of the SCN clockwork

0950-1030h William Schwartz
Splitting a circadian clock: two circadian oscillations in the suprachiasmatic nucleus.

1030-1100h Coffee Break

1100-1140h Gregory Cahill
Genetic Analysis of the Zebrafish Circadian System

1140-1220h Hilmar Meissl
Retinal influences on the biological clock: systemic and cellular mechanisms.

1230h Lunch

Hot Topics, Animal and human aspects
1600-1800h 10 minutes presentation plus 5 minutes discussion.

1600-1615h Vinod Kumar, Sudhi Singh and Manju Mishra;
Melatonin is not involved in the photoperiodic time measurement in birds. Department of Zoology, University of Lucknow, Lucknow 226 007, India

1615-1630h Aarseth Jo Jarem.
Plasma concentrations of melatonin in newborn harp seals. Department of Arctic Biology, University of Tromso, Norway.

1630-1645h Tricoire Hélène. Locatelli A, Cheminau P, Moller M, Malpaux B.
Evidence for a direct secretion of melatonin from the pineal gland to the cerebrospinal fluid of the third ventricle. Neuroendocrinologie Sexuelle, PRC, UMR INRA-CNRS-Universite Francois rabelais, 37380 Nouzilly, France.

1645-1700h Forsling Mary L.
The effect of melatonin on neurohypophysial function in women. Neuroendocrine Laboratories, GKT School of Medicine, Guys Campus, London SE1 1UL.

1700-1715h Kripke Daniel F, Youngstedt SD, Elliot JA.
Melatonin phase abnormalities in major depression. University of California, San Diego 92093-0667, USA.

1715-1730h Monk Timothy H.
Plasma melatonin as a predictor of circadian alertness rhythm phase and morningness/eveningness. Sleep and Chronobiology Centre, University of Pittsburgh, Pittsburgh, USA.

1730-1745h Samel Alexander. Drummer C, Luks N, Vejvoda M, Nickelsen T.
Chronobiotic effects of a melatonin agonist follwing a simulated 9-h advance time shift. DLR-Institute of Aerospace Medicine, D-51170 Koln, Germany.

1745-1800h Zhdanova Irina V.
Effects of Melatonin on sleep in diurnal species. MIT, E18-439, 50 Ames St., Cambridge, MA 02139, USA.

1800h Dinner

Session 7 Melatonin, Sleep and Body Temperature
Discussion Leader: Angelo Cagnacci

1930-1940h Introduction Angelo Cagnacci

1940-2020h Anna Wirz-Justice
Melatonin and thermoregulation

2020-2100h Drew Dawson
Melatonin, an autonomic regulator of thermoregulation

2100-2140h Derk-Jan Dijk
Circadian regulation of human sleep: a role for melatonin

Session 8 Clinical aspects of melatonin, its agonists and antagonists
Discussion Leader: Peter Morgan

0900-0910h Introduction Peter Morgan

0910-0950h Fred Turek
Effects of age on sleep and rhythmicity: possible therapeutic benefits of melatonin related drugs.

0950-1030h Steven Hill
Prevention and regression of breast cancer by the combination of melatonin and retinoic acid

1030-1100h Coffee Break

1100-1140h David Sugden
The melanophore bioassay: a tool for studying melatonin receptor ligands

1140-1220h Michael Flaugh
Preliminary clinical studies on the melatonin agonist LY156735

1230 Lunch

1530-1730h Posters

1730-1800h Business meeting

1800-2000h Banquet

Session 9 Pineal controversies: Debate-does the pineal have an essential role or indeed a role in the mammalian circadian system?
Discussion Leader: Michael Hastings

2030-2040 Introduction Michael Hastings

2040-2120h Vincent Cassone
What, exactly, does pineal melatonin do, exactly?

2120-2200h Alfred J. Lewy
Entrainment of the human biological clock by the light/dark cycle: Augmentation by endogenous melatonin production?

2200-2210h Summary Michael Hastings