SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:15 pm - 7:25 pm | Welcome / Introductory Comments by GRC Site Staff and GRC Chair (Jörg H. Stehle) |
7:25 pm - 8:30 pm | REGULATION OF PINEAL MELATONIN SYNTHESIS - NEW TWISTS IN AN OLD STORY |
| Discussion Leader: Helena Illnerova (Academy of Sciences, Czech Republic) |
7:25 pm - 7:35 pm | Opening remarks |
7:35 pm - 7:55 pm | Steve Coon (National Institutes of Health, USA)
"Twist and Turns in AANAT Evolution" |
7:55 pm - 8:15 pm | Anthony Ho (University of Alberta, Canada)
"Histone modifications and Aa-nat gene expression" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:30 pm | KEYNOTE TALK I |
| Discussion Leader: Debra Skene (University of Surrey, United Kingdom) |
8:30 pm - 8:40 pm | Opening remarks |
8:40 pm - 9:20 pm | Josephine Arendt (University of Surrey, United Kingdom)
"The Impact of Melatonin on Human Health" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | THE MELATONIN MESSAGE AND DISEASE |
| Discussion Leader: Joseph Takahashi (Northwestern University, USA) |
9:00 am - 9:10 am | Opening remarks |
9:10 am - 9:30 am | Thomas Bourgeron (Institut Pasteur, France)
"Abnormal synapses and melatonin synthesis in autism spectrum disorders" |
9:30 am - 9:50 am | Dick Swaab (The Netherlands Institute for Neuroscience, The Netherlands)
"Melatonin receptor localization in the human brain in health and disease" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 12:30 pm | MELATONIN RECEPTORS - WHAT ARE THEY GOOD FOR? |
| Discussion Leader: David R. Weaver (University of Massachusetts Medical School, USA) |
10:30 am - 10:40 am | Opening remarks |
10:40 am - 11:00 am | Ralf Jockers (University Paris-Descartes, France)
"Regulation of the melatonin receptors by associated protein complexes" |
11:00 am - 11:20 am | Jean Boutin (Institut de Recherches Servier, France)
"Melatonin binding site MT3 is QR2: facts and consequences" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Shantha Rajaratnam (Monash University, Australia)
"Phase-shifting and sleep-promoting effects of melatonin and its analogues" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Jonathan Johnston (University of Surrey, United Kingdom)
"Developmental plasticity of melatonin receptor expression" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | MANAGEMENT OF TIME IN HUMAN CHRONOBIOLOGY |
| Discussion Leader: Alfred Lewy (Oregon Health Sciences University, USA) |
5:30 pm - 5:40 pm | Opening remarks |
5:40 pm - 6:00 pm | Debra Skene (University of Surrey, United Kingdom)
"Ageing and nonvisual light responses in humans" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Steven Lockley (Harvard Medical School, USA)
"The role of photic and non-photic time cues on circadian organisation in humans" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Till Roenneberg (Ludwig-Maximilians-University Munich, Germany)
"Physiology and genetics of human daily behaviour - an approach of system biology in human" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:30 pm | General Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:00 pm | RETINA AND MELATONIN - SEEING THE CLOCK? |
| Discussion Leader: Ignacio Provencio (University of Virginia, USA) |
9:00 am - 9:10 am | Opening remarks |
9:10 am - 9:30 am | Gianluca Tosini (Morehouse School of Medicine, USA)
"Role of melatonin and melatonin receptors in the regulation of retinal circadian rhythms" |
9:30 am - 9:50 am | Michael Iuvone (Emory University, USA)
"Dopamine and circadian organization of the mouse retina" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
| Discussion Leader: Michael Iuvone (Emory University, USA) |
10:30 am - 10:40 am | Opening remarks |
10:40 am - 11:00 am | Ignacio Provencio (University of Virginia, USA)
"Melanopsin - more than just a circadian photopigment" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Russel Foster (University of Oxford, United Kingdom)
"VA opsin - more than just a teleost photopigment" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:50 am | General Discussion |
11:50 am - 12:30 pm | HOT TOPICS I |
| Session Chair: Carla Green (University of Virginia, USA) |
11:50 am - 12:00 pm | Opening remarks |
12:00 pm - 12:10 pm | Chad Jackson (Emory University, Atlanta, USA)
"Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in retinal photoreceptor cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Shahar Alon (Tel Aviv University, Israel)
"In-silico identification and in-vivo validation of a new DNA binding site governing pineal-specific expression" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | RHYTHMS IN THE PERIPHERY - THE ROLE OF MELATONIN |
| Discussion Leader: Michael Menaker (University of Virginia, USA) |
5:30 pm - 5:40 pm | Opening remarks |
5:40 pm - 6:00 pm | Andries Kalsbeek (The Netherlands Institute of Brain Research, The Netherlands)
"Interplay of central, pineal and peripheral clocks and metabolic rhythms" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | David Hazlerigg (University of Aberdeen, United Kingdom)
"Wrestling with melatonin-dependent transcriptional control" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Sandrine Dupré (University of Manchester, United Kingdom)
"Controlling seasonal rhythms in mammals: Identification of new genes and pathways in the sheep pars tuberalis" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:30 pm | General Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:00 pm | PINEAL REGULATORS DURING EVOLUTION, THROUGH LIFE-SPAN, WITH SEASON, DAY-BY-DAY |
| Discussion Leader: Carla Green (University of Virginia, USA) |
9:00 am - 9:10 am | Opening remarks |
9:10 am - 9:30 am | Elise Cau (University of Toulouse, France)
"Specification of neuronal subtypes in the zebrafish pineal gland" |
9:30 am - 9:50 am | Yoav Gothilf (Tel Aviv University, Israel)
"The zebrafish clock sheds light on the mechanism of entrainment" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Martin Rath (University of Copenhagen, Denmark)
"Developmental and diurnal dynamics of Pax4 expression in the rat pineal gland and retina" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Joseph Takahashi (Northwestern University, USA)
"Clock genes, cell autonomy and circadian organization in mouse" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | General Discussion |
11:50 am - 12:30 pm | SHORT TALKS |
| Session Chair: Andrew Loudon (University of Manchester, United Kingdom) |
11:50 am - 12:00 pm | Opening remarks |
12:00 pm - 12:10 pm | Martine Migaud (INRA CNRS UMR 1291, Nouzilly, France)
"Melatonin and melatonin receptors: how do they cope together in the brain?" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Husam Abu-Soud (Wayne State University, Detroit, USA)
"Melatonin is a Potent Inhibitor of Myeloperoxidase" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session III |
5:30 pm - 7:10 pm | LINKING MELATONIN AND CLOCKS WITH DISEASE AND THE IMMUNE SYSTEM |
| Discussion Leader: George Brainard (Jefferson Medical College, USA) |
5:30 pm - 5:40 pm | Opening remarks |
5:40 pm - 6:00 pm | David Blask (Bassett Research Institute, USA)
"Role of Melatonin in Circadian Cancer Prevention" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Marina Antoch (Cleveland Clinic Foundation, USA)
"Circadian proteins, ageing and tumorigenesis" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Eus van Someren (Netherlands Institute for Neuroscience, The Netherlands)
"Chronic melatonin and light treatment in demented elderly" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:10 am | THE ROLE OF THE PINEAL IN CLOCKING SEASONAL ADAPTATION |
| Discussion Leader: David Kennaway (University of Adelaide, Australia) |
9:00 am - 9:10 am | Opening remarks |
9:10 am - 9:30 am | Annika Herwig (Rowett Institute, Aberdeen, United Kingdom)
"Cool clocks" |
9:30 am - 9:50 am | Gerald Lincoln (Queen's Medical Research Institute, Edinburgh, United Kingdom)
"Melatonin signals and circannual clocks" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Valerie Simonneaux (University of Strasbourg, France)
"Melatonin-mediated expression of hypothalamic genes involved in the regulation seasonal reproduction?" |
10:50 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | HOT TOPICS II |
| Discussion Leader: Elizabeth Maywood (MRC-Cambridge, United Kingdom) |
11:00 am - 11:10 am | Opening remarks |
11:10 am - 11:20 am | Sandra Lesny (University Frankfurt, Germany)
"Melatonin affects daily patterns of hippocampal clock gene expression and spatial learning in the mouse" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Tolga Uz (University of Illinois, Chicago, USA)
"Melatonin through melatonin receptors regulates cocaine/dopamine system-induced neuronal signaling and addictive behaviors in mice" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Marco Koch (University of Frankfurt) "The rat pineal gland comprises an endocannabinoid system" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | James Olcese (Florida State University College of Medicine, Tallahassee, USA)
"Melatonin and the timing of human birth" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Steven Hill (Tulane University School of Medicine, New Orleans, USA)
"Melatonin suppression of breast tumor cell invasion is mediated via the MT1 Receptor" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session IV |
5:30 pm - 6:30 pm | HOT TOPICS III |
| Session Chair: Peter Morgan (Rowett Institute, United Kingdom) |
5:30 pm - 5:40 pm | Opening remarks |
5:40 pm - 5:50 pm | Gad Vatine (Tel Aviv University, Israel)
"Light-induced expression of zebrafish Period2" |
5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:05 pm | Kazuhiro Shimomura (Northwestern University, Evanston, USA)
"Does melatonin suppress the Clock mutation in mouse?" |
6:05 pm - 6:10 pm | Discussion |
6:10 pm - 6:20 pm | Katrin Ackermann (University of Frankfurt, Germany)
"New aspects in regulation of melatonin synthesis in the human pineal gland" |
6:20 pm - 6:25 pm | Discussion |
6:25 pm - 6:30 pm | Break |
6:30 pm - 7:30 pm | KEYNOTE TALK II |
| Discussion Leader: David R. Weaver (University of Massachusetts Medical School, USA) |
6:30 pm - 6:40 pm | Opening remarks |
6:40 pm - 7:20 pm | Steven M. Reppert (University of Massachusetts Medical School, USA)
"The Ancestral Circadian Clock of Monarch Butterflies: Role in Sun Compass Orientation" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |