SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Opening Remarks - Hallgeir Rui (Conference Chair) |
7:40 pm - 7:50 pm | Welcome / Introductory Comments by GRC Site Staff |
7:50 pm - 9:20 pm | Transcriptional Control of PRL and GH genes |
| Discussion Leader: Hallgeir Rui (Thomas Jefferson University, USA) |
7:50 pm - 8:30 pm | Arthur Gutierrez-Hartmann (University of Colorado, USA) "Combinatorial Mechanisms Governing Prolactin Gene Transcription" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Nancy Cooke (University of Pennsylvania, USA) "Long-range activation of the human growth hormone gene cluster" |
9:20 pm - 9:30 pm | Discussion |
9:20 pm | Welcome Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:55 am | PRL & GH Pathway Mutations and Polymorphisms |
| Discussion Leader: Stephen Liebhaber (University of Pennsylvania, USA) |
9:05 am - 9:30 am | Anders Juul (University of Copenhagen, Denmark) "d3-GH receptor polymorphism: associations to pre- and postnatal growth" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Ron Rosenfeld (Lucile Packard Foundation for Children’s Health, USA) "Stat5 mutations and growth" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Asta Försti (German Cancer Research Center, Germany) "PRL and GH polymorphisms and human breast cancer risk" |
10:40 am - 10:50 am | Discussion |
10:50 am - 11:20 am | Coffee Break / Group Photo (11:15 am) |
11:20 am - 11:45 am | Philippe Touraine (INSERM, France) "PRLR polymorphisms and breast diseases" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Platform 1 and 2 talks |
11:55 am - 12:05 pm | Samantha Oakes (Garvan Institute of Medical Research, Australia) "The Ets transcription factor Elf5 specifies mammary alveolar cell fate" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Kazuhito Sakamoto (University of Nebraska, USA) "The ablation of Jak2 reduces mammary epithelial cell proliferation and protects against Her2/neu-induced mammary tumorigenesis" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:20 pm | PRL & GH Intracellular Signaling |
| Discussion Leader: Linda Schuler (University of Wisconsin, USA) |
7:35 pm - 8:00 pm | Christin Carter-Su (University of Michigan, USA) "The role of JAK2 phosphorylation sites and binding proteins in the actions of GH" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Charles Streuli (University of Manchester, UK) "PRL Signaling and extracellular matrix" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Ted Elsasser (United States Department of Agriculture,USA) "GH associated nitration of Jak2: impact on signalling" |
9:10 pm - 9:20 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:55 am | Clinical and Pathological aspects of PRL and GH |
| Discussion Leader: Charles Clevenger (Northwestern University, USA) |
9:05 am - 9:30 am | Michael Thorner (University of Virginia, USA) "The matrix of ghrelin, insulin, growth hormone and cortisol in metabolic regulation in man" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | A.J. van der Lely (Erasmus Medical Centre, Netherlands) "Clinical use of GH receptor antagonists: recent insight" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | George Bright (Tercica, USA) "IGF-1 treatment in severe growth failure" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Ken Ho (Garvan Institute of Medical Research, Australia) "Modulation of GH action by sex steroids" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Platform 1 and 2 talks |
11:55 am - 12:05 pm | Shigeru Okada (Ohio University, USA) "Proteomic analysis of serum from patients with acromegaly" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Estelle Tallet (INSERM, France) "A New Surface Plasmon Resonance Set Up To Characterize The Interactions Within Prl-Prlr Complexes" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:20 pm | Stem Cells in GH and PRL target organs |
| Discussion Leader: Kay-Uwe Wagner (University of Nebraska, USA) |
7:35 pm - 8:00 pm | Gabriela Dontu (University of Michigan, USA) "GH regulation of self-renewal of mammary stem cells" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Gil Smith (National Institute of Health, USA) "Stem Cells and the Mammary Microenvironment" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Michael Waters (University of Queensland, Australia) "GH regulation of neural stem cell number" |
9:10 pm - 9:20 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:55 am | PRL/GH Target Organs |
| Discussion Leader: Geula Gibori (University of Illinois, USA) |
9:05 am - 9:30 am | Nadine Binart (INSERM, France) "PRL and ovary" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Peter Lobie (University of Auckland, New Zealand) "GH and breast cancer promotion" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Michael Freemark (Duke University, USA) "Metabolic actions of PRL and GH" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Seung Kim (Stanford University School of Medicine, USA) "Prolactin signaling controls pancreatic beta-cell menin levels and proliferation in pregnant mice" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:30 pm | Platform 1 and 2 talks |
11:55 am - 12:05 pm | Isabelle Broutin (Université Paris Descartes, France) "X-ray structures of the 2:1 complex between PRL and its receptor" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Jiamao Zheng (Northwestern University, USA) "The peptidyl-prolyl isomerase cyclophilin A regulates activation of the prolactin receptor/Jak2 complex and the progression of human breast cancer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:20 pm | PRL and GH-related ligands |
| Discussion Leader: Carmen Clapp (Universidad Nacional Autonoma de Mexico, Mexico) |
7:35 pm - 8:00 pm | Joseph Martial (University of Liege, Belgium) "PRL and GH-derived antiangiogenic peptides" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Philipp Fischer (Hannover Medical School, Germany)
"16K PRL in cardiac physiology and disease" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Richard Ross (University of Sheffield, UK) "A ligand-receptor fusion of growth hormone is a potent long-acting agonist" |
9:10 pm - 9:20 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:55 am | Pituitary and CNS |
| Discussion Leader: Julian Davis (University of Manchester, UK) |
9:05 am - 9:30 am | Dave Grattan (University of Otago, New Zealand) "Hormone-induced changes in PRL signal transduction in the rat hypothalamus during late pregnancy" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Robert Bridges (Tufts University, USA) "Alterations in the Neuroendocrine Regulation and Neural Actions of Prolactin by Reproductive Experience" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Gloria Mak (University of Calgary, Canada) "The role of prolactin in male pheromone-induced neurogenesis" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Shlomo Melmed (Cedars Sinai Medical Center, USA) "Pituitary Tumorigenesis - New Insights" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Platform 1 and 2 talks |
11:55 am - 12:05 pm | Celina Garcia (Universidad Nacional Autonoma de Mexico, Mexico) "Vasoinhibins prevent increased retinal vasopermeability associated with diabetic retinopathy via protein phosphatase 2A-dependent eNOS inactivation" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Maris Laan (University of Tartu, Estonia) "Resequencing The Five Human Growth Hormone/Chorionic Somatomammotropin Genes At 17q22-24: Locus And Population-Specific Genetic Heterogeneity" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 8:35 pm | Keynote Lecture |
| Discussion Leader: Vincent Goffin (INSERM, France) |
7:35 pm - 8:20 pm | Michael Lisanti (Thomas Jefferson University, USA) "Caveolins, PRL and GH signaling" |
8:20 pm - 8:35 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |