The Gordon Research Conference on Glycolipid and Sphingolipid Biology, the tenth in this series, promises to be an exciting and instructive meeting. One challenge is to understand how the chemical structure of glycolipids and sphingolipids dictates their physical behavior in membrane organization and dynamics during transport and signaling. Another challenge is to find out how the local glyco/sphingolipid concentration is regulated by transport proteins and metabolic enzymes, including their regulation at the level of gene expression and post-translational modification. Finally, we need to find out how our knowledge of these processes can be used to understand celluar (patho)physiology and interfere with disease. With the help of all attendants we'll try to cover the significant developments and perspectives all the way from biophysics/structure, genetics, metabolism/sphingolipidomics/novel techniques, transport/toxin, signaling/immunology, to cancer/Alzheimer disease/mouse models. Next to the invited presentations by leaders in the field, exciting posters will be selected for oral presentation. We will have ample discussion after each talks, during the poster sessions and at our Italian meals.