| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:30 pm - 9:30 pm | Development of the immune system |
| Discussion Leader: Hergen Spits |
| 7:35 pm - 7:55 pm | Hergen Spits
"The Multiple roles of STAT5 in human B cell development" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Katia Georgopoulos (Harvard University)
"Mission Impossible in the hematopoietic stem cell" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Albert Bendelac (University of Chicago)
"Cellular and molecular regulation of thymic NKT lineage development" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Hans-Reimer Rodewald (Ulm University, Germany)
"From nude mouse complementation to the second thymus" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Evolution of self-non-self recognition strategies in the immune system |
| Discussion Leader: Mitch Kronenberg (La Jolla Institute) |
| 9:00 am - 9:20 am | Mitch Kronenberg (La Jolla Institute)
"Evolutionary conservation of the recognition of bacterial glycolipids by NKT cells" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Deitmar Schmucker (Harvard University)
"Hypervariable Ig-receptors in invertebrate immunity" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Tom Boehm (Max-Planck Institute)
"Quality control in anticipatory immune systems" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Max Cooper (University of Alabama, Birmingham)
"Contrasting Adaptive Immunity in Jawless vs Jawed Vertebrates" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am | Coffee Break |
| 11:15 am | Group Photo |
| 11:30 am - 11:50 am | Tony De Tomaso (Stanford University)
"Self/Non-self recognition in a primitive chordate" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Michael Shapira (Stanford University School of Medicine)
"Elucidating molecular mechanisms of epithelial innate immunity using C. elegans" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Innate Immunity |
| Discussion Leader: Caetano Reis e Sousa (Cancer Research UK) |
| 7:30 pm - 7:50 pm | Caetano Reis e Sousa (Cancer Research UK)
"Regulation of DC phenotype and function by C-type lectins" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Richard Locksley (UCSF)
"The initiation of allergic immunity" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Marco Colona (Washington University, St. Louis)
"ITAM and TLR signals: cross-talk in dendritic cells" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Bruce Beutler (The Scripps Research Institute)
"Forward Genetic Analysis of Innate Immunity" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Antigen presentation and lymphocyte activation |
| Discussion Leader: Gary Koretzky (University of Pennsylvania) |
| 9:00 am - 9:20 am | Gary Koretzky (University of Pennsylvania)
"Integrating Lymphocyte Activation Signals with Adapter Proteins" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Nilabh Shastri (University of California)
"Mechanisms for generating TCR ligands" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Peter Cresswell (Yale University)
"Molecular analysis of tapasin-mediated MHC class l peptide loading" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Susan Pierce (NIH)
"Viewing the earliest events in B cell activation by live cell imaging" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | John Chang (University of Pennsylvania)
"Asymmetric T Lymphocyte Division Initiating Adaptive Immunity" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Navreet Nanda (NIH)
"Epitope selection by DM underlies BALB/c susceptibility to Leishmania major" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Carla Rothlin (Salk Institute)
"TAM Receptor Signaling in Dendritic Cells Negatively Regulates the Innate Immune Response" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Dynamics of leukocyte interactions |
| Discussion Leader: Uli von Andrian (Harvard University) |
| 7:30 pm - 7:50 pm | Uli von Andrian (Harvard University)
"Imaging innate and adaptive immune responses to lymph-borne viruses" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Mark Davis (Stanford University)
"The role of self peptides in T cell activation and thymic selection" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Ronald Germain (NIAID/NIH)
"Dynamic Imaging of Immune Cell Behavior and Function in Vivo" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Avi Kupfer (John Hopkins)
"T cell activation: a view from the center" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TNF and Ig family costimulatory pathways |
| Discussion Leader: Arlene Sharpe (Harvard University) |
| 9:00 am - 9:20 am | Arlene Sharpe (Harvard University)
"Role of new pathways in the B7:CD28 family in regulating T cell activation and tolerance" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Michael Croft (La Jolla Institute)
"Costimulatory Signals Controlling T cell Division and Survival" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Jim Allison (Memorial Sloan-Kettering Cancer Center)
"T cell checkpoint and Cancer Immunotherapy" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Simon Davis
"Triggering of CD28 and related receptors" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Anjali De Souza (University Of Pittsburgh)
"T cell Ig and mucin-1 (TIM-1) is expressed on in vivo-activated T cells and provides a co-stimulatory signal for T cell activation" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Ena Ladi (UC Berkeley)
"Visualizing Dendritic Cell Interactions with Migrating Thymocytes in Real-time Using Two-Photon Microscopy" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Maureen McGargill (University of California, San Diego)
"The role of Drak2 in autoimmunity is restricted to T cell-mediated organ specific autoimmune diseases" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Tolerance and autoimmunity |
| Discussion Leader: Alexander Rudensky (University of Washington) |
| 7:30 pm - 7:50 pm | Alexander Rudensky (University of Washington)
"Genetic mechanisms of dominant tolerance" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Dan Cua (DNAX Research)
"Regulation of the IL-23/IL-17 Immune Pathway" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Diane Mathis (Harvard University)
"Molecular controls on immunological tolerance" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Shannon Turley (Dana Faber Cancer Institute, Harvard)
"Unconventional mechanism of tolerance induction to intestinal self" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mucosal Immunity |
| Discussion Leader: Adrian Hayday |
| 9:00 am - 9:20 am | Adrian Hayday
"The development and function of resident intraepithelial T cells" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Andrew MacPherson (McMaster University, Canada)
"The role of IgA in immune mutualism with the commencal intestinal microflora" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Dana Philpott (University of Toronto)
"Innate immunity mediated by Nod-like receptors" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Hans-Christian Reinecker (Harvard University/MGH)
"Antigen recognition and Mucosal Defenses" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Min Fang (Fox Chase Cancer Center)
"NKG2D plays a partial role in NK cell mediated resistance to mousepox" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Stephen McSorley (University of Minnesota)
"Visualization of antigen presentation and CD4 T cell activation during local bacterial infection reveals a requirement for CCR6-dependent recruitment of blood phagocytes" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Eun Jeong Park (The CBR Institute for Biomedical Research)
"Aberrant Activation of Integrin alpha4beta7 Suppresses Lymphocyte Migration to the Gut" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Infectious disease |
| Discussion Leader: Rafi Ahmed (Emory) |
| 7:30 pm - 7:50 pm | Rafi Ahmed (Emory)
"Immunological Strategies for Curing Chronic Viral Infections" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Christine Biron
"Regulation of Type 1 Interferon Effects on NK and T Cells" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Christopher Hunter (University of Pennsylvania)
"Checks and balances in infection-induced pathology" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Yasmine Belkaid (NIAID/NIH)
"Role and antigen specificity of natural treg during parasitic infections" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |