Conference Program
 
Drug Metabolism
July 6-11, 2008
Holderness School
Holderness, NH
Chair:
Timothy S. Tracy

Vice Chair:
Donald J. Tweedie

Welcome to the Drug Metabolism Gordon Research Conference page where you can find the preliminary program and important registration information. The Drug Metabolism scientific programs focus on current frontiers of science concerning the metabolism and disposition of drugs and related xenobiotics. The theme for the 38th Gordon Research Conference on Drug Metabolism is "Predicting In Vivo Drug Disposition: The Fundamentals Still Matter" The program will follow the traditional GRC Drug Metabolism format with the keynote lecture Sunday evening, 4 morning sessions with 4 speakers each, 3 evening sessions with 3 speakers each, and Wednesday evening 6 graduate students and postdoctoral fellows will make oral presentations selected from the outstanding posters submitted. Participants are encouraged to submit poster presentations, with the sessions organized by Vice Chair Donald Tweedie. We had a record 65 posters last year and are hoping for even more this year.

Social activities will include the annual Industry vs. Academia softball game (bring your glove, if possible) on Tuesday afternoon. In addition, a golf outing (green fees not included) is planned for Wednesday afternoon.

Note that housing and meals are included in the registration fee. Come join us in New Hampshire!

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome by Conference Chair, Timothy S. Tracy
Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Opening Session - Drug Metabolism: Past, Present, and Future
7:40 pm - 9:00 pmSteven Wrighton (Eli Lilly and Co.)
"Drug Metabolism: Past, Present and Future"
9:00 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pm The P450 Cycle and Kinetics of Substrate Metabolism
Discussion Leader: Ken Korzekwa (Allchemie, Inc.)
9:00 am - 9:30 amStephen Sligar (University of Illinois)
"Drug metabolism and enzyme ‘cooperativity’"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amJeff Jones (Washington State University)
"The differing effects of substrate interactions with the heme-iron: is type II binding a dead-end complex?"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 amLucy Waskell (University of Michigan)
"Cytochrome b5 catalyzes product formation by P450 2B4 faster than reductase and competes with reductase for a binding site on P450 2B4"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pmAndrew Munro (University of Manchester)
"Transient kinetic studies of Mycobacterium tuberculosis drug target P450s"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm UGT Polymorphisms and Drug Interactions / Adverse Reactions
Discussion Leader: Michael Court (Tufts University)
7:30 pm - 7:55 pmPhilip Lazarus (Penn State University)
"UGT pharmacogenetics and breast cancer prevention and treatment"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmChristian P. Strassburg (Hannover Medical School, Germany)
"Gilbert’s Syndrome: just a variant or more? - UGT variation and drug toxicity"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmChantal Guillemette (Laval University, Canada)
"Variability in human UGTs: polymorphisms to new and unique genomic variations"
9:15 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Novel Metabolism Reactions and Toxicity
Discussion Leader: Matthew Hutzler (Pfizer, Inc.)
9:00 am - 9:30 amDan Rock (Amgen, Inc.)
"The role of P450 active site architecture in exposure to reactive metabolites"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amJack Uetrecht (University of Toronto, Canada)
"Non-P450-generated reactive metabolites and determination of their significance"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 amJeffrey Stevens (Pfizer, Inc.)
"Impact of FMO-mediated metabolism in drug discovery"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pmHansen Wong (Vanderbilt University)
"Stress signaling via alkylation of JNK and NF-κB pathway proteins by reactive electrophiles"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm Modeling and Simulation in Preclinical and Clinical Drug Development
Discussion Leader: Steven Hall (Eli Lilly and Co.)
7:30 pm - 7:55 pmSandra Allerheiligen (Eli Lilly and Co.)
"Applications of quantitative pharmacology to drug discovery and development optimization"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmChristine Garnett (U.S. Food and Drug Administration)
"The utility of modeling and simulation in the new drug evaluation environment"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmGeoffrey Tucker (University of Sheffield, United Kingdom)
"Integrating demographic, physiological, genetic, and in vitro data: The bottom-up approach to population PK"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Endogenous Substrates of Multi-Functional Drug-Metabolizing Enzymes
Discussion Leader: Ken Thummel (University of Washington)
9:00 am - 9:30 amDeanna Kroetz (University of California, San Francisco)
"Renal EETs and Soluble Epoxide Hydrolase in Acute Kidney Injury"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amRheem Totah (University of Washington)
"CYP2C8 and EET formation"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 amHenry Strobel (University of Texas Medical School at Houston)
"CYP4F enzymes and brain metabolism"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Darryl Zeldin (NIEHS)
"Role of P450 Epoxygenases in Cardiovascular Function"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm Student/Trainee Presentations
Discussion Leader: Henry Strobel (University of Texas Medical School at Houston)
7:30 pm - 7:45 pm Student/Trainee Presenter 1 (TBA)
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:05 pm Student/Trainee Presenter 2 (TBA)
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:25 pm Student/Trainee Presenter 3 (TBA)
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm Student/Trainee Presenter 4 (TBA)
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Student/Trainee Presenter 5 (TBA)
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Student/Trainee Presenter 6 (TBA)
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Drug Transporters: Structure, Function, Regulation and Clinical Translation
Discussion Leader: Kim Brouwer (University of North Carolina at Chapel Hill)
9:00 am - 9:30 amStephen Wright (University of Arizona)
"Structure/Function assessment of organic cation transporters (OCTs and MATEs)"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 amPeter Swaan (University of Maryland)
"Structure/Function relationships of bile acid transporters"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 amGuofeng You (Rutgers University)
"Regulation of organic anion transporters (OATs)"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pmJoseph Ware (Genentech, Inc.)
"ABCG2 (BCRP) structure, activity, and clinical translation"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pm New Technologies in Drug Metabolism
Discussion Leader: Larry Wienkers (Amgen, Inc.)
7:30 pm - 7:55 pmThomas M. Laue (University of New Hampshire)
"Direct physical methods for determining properties of macromolecules and the extent of ligand binding"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pmGordon Tollin (University of Arizona)
"Plasmon-Waveguide resonance spectroscopy as a tool for understanding membrane protein function"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:15 pmJonathan B. Chaires (University of Louisville)
"Clinical colorimetry?"
9:15 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture