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Conference Program
 
Calcium Signalling
June 21-26, 2009
Il Ciocco Hotel and Resort
Lucca (Barga), Italy
Chair:
Alexei V. Tepikin

Vice Chair:
J. Kevin Foskett

The 2009 Gordon Conference on Ca2+ Signaling will present cutting-edge research on the cellular regulation and downstream functions of this remarkable ion-messenger. The Conference will be opened by a "State of the Field" lecture by Tullio Pozzan from the University of Padua, which will provide a brief overview of the achievements, problems and perspectives of Ca2+ signaling research. The first sessions of the conference will be dedicated to the roles played by Ca2+ in bioenergetics, apoptosis, important diseases and aging. During the following sessions we will discuss a wide range of topics such as calcium stores and calcium release channels, mechanisms of Ca2+ entry, comparative physiology of Ca2+ signals, interacting second messenger cascades and properties of Ca2+-binding proteins. For the first time in the history of this conference we are planning to include an open debate between two prominent scientists; the debate will be focused on the mechanisms of Ca2+ entry. The conference will be finished by a Keynote Lecture which will be presented by Tobias Meyer from Stanford University.

The conference will bring together researchers specializing in fundamental aspects of calcium signaling and scientists with interests in the roles played by Ca2+ in physiological reactions and in many important diseases (e.g. cardiovascular diseases, cancer, Alzheimer's disease and others). 32 scientists working at the forefront of Ca2+ signaling research have agreed to present lectures or serve as discussion leaders. The conference will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. 6 poster presenters will be selected for short talks.

The conference will be held in Il Ciocco Hotel in Tuscany. The site is located on two thousand acres of a spectacular natural park, which will provide an excellent setting for informal out-of-session discussions.


Contributors

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:45 pmIntroductory Comments by Alexei Tepikin and Kevin Foskett
7:45 pm - 9:30 pmCALCIUM SIGNALLING IN BIOENERGETICS AND APOPTOSIS
7:45 pm - 8:15 pm Discussion Leader: Tullio Pozzan (University of Padua)
"State of the field (review/introductory lecture)"
8:15 pm - 8:40 pm Rosario Rizzuto (University of Ferrara)
"Mitochondrial calcium channels in apoptosis and autophagy"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Michael Duchen (University College London)
"Modulation of mitochondrial pathways of apoptosis by the ATPase inhibitory protein, IF1"
9:15 pm - 9:25 pm Discussion
9:25 pm - 9:30 pm General Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCALCIUM SIGNALLING IN DISEASE AND AGING
9:00 am - 9:05 am Discussion Leader: Ernesto Carafoli (University of Padua)
"Introduction"
9:05 am - 9:30 am Stephen Pandol (UCLA School of Medicine)
"Calcium, a co-conspirator in pancreatitis?"
9:30 am - 9:45 am Discussion
9:45 am - 9:55 am Hiroko Bannai (RIKEN, Japan)
"Calcium-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break / Group Photo
10:30 am - 10:55 am Natalia Prevarskaya (University of Lille)
"Calcium and cancer hallmarks"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Grace E. Stutzmann (Rosalind Franklin University)
"Deviant neuronal calcium signalling and early synaptic deficits in Alzheimer's disease"
11:35 am - 11:50 am Discussion
11:50 am - 12:15 pm Llewelyn Roderick (The Babraham Institute)
"Calcium signaling and cardiac hypertrophy"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 1
5:30 pm - 7:30 pmCALCIUM STORES AND CALCIUM RELEASE CHANNELS
5:30 pm - 5:35 pm Discussion Leader: Aldebaran Hofer (Harvard Medical School)
"Introduction"
5:35 pm - 6:00 pm Antony Galione (Oxford University)
"NAADP receptors and their role in calcium signaling"
6:00 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm Barbara Ehrlich (Yale University)
"Regulation of intracellular calcium release by calcium binding proteins"
6:40 pm - 6:55 pm Discussion
6:55 pm - 7:20 pm Colin Taylor (Cambridge University)
"Tuning the sensitivity of IP3 receptors"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMECHANISMS OF CA2+ ENTRY
9:00 am - 9:05 am Discussion Leader: Anjana Rao (Harvard Medical School)
"Introduction"
9:05 am - 9:30 am Anant Parekh (Oxford University)
"Mechanisms regulating STIM1 movement and ICRAC activation"
9:30 am - 9:45 am Discussion
9:45 am - 9:55 am Late Breaking Science Talk: Trevor Shuttleworth (University of Rochester)
"Orai subunit ARChitecture of ARC channels"
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Indu Ambudkar (National Institute of Health/NIDCR)
"Lipid rafts domains and regulation of store-operated calcium entry"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am Richard Lewis (Stanford University School of Medicine)
"A molecular mechanism for CRAC channel activation"
11:35 am - 11:50 am Discussion
11:50 am - 12:10 pm Late Breaking Science Talk: Patrick Hogan (Harvard Medical School)
"STIM1, Orai1, and store-operated calcium entry"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 1
5:30 pm - 7:30 pmCHANNELS INVOLVED IN CA2+ ENTRY
5:30 pm - 5:35 pm Discussion Leader: Kevin Foskett (University of Pennsylvania)
"Introduction"
5:35 pm - 5:55 pm Late Breaking Science Talk: Don Gill (Temple University School of Medicine)
5:55 pm - 6:05 pm Discussion
6:05 pm - 6:15 pm Ivan Bogeski (Saarland University, Germany)
"Redox regulation of Orai channels: a mechanism to tune T-cell responses"
6:15 pm - 6:20 pm Discussion
6:20 pm - 6:30 pm Roger J. Thompson (Hotchkiss Brain Institute, Calgary, Canada)
"Pannexin-1 Channels and Neuronal Calcium Deregulation"
6:30 pm - 6:35 pm Discussion
6:35 pm - 7:30 pm Debate: "Are TRP channels involved in store-operated Ca2+ entry?"
Shmuel Muallem (University of Texas, Southwestern Medical Centre) vs. Jim Putney (National Institute of Environmental Health Science)
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmINTERACTING SECOND MESSENGER CASCADES
9:00 am - 9:05 am Discussion Leader: Indu Ambudkar (National Institute of Health/NIDCR)
"Introduction"
9:05 am - 9:30 am Aldebaran Hofer (Harvard Medical School)
"Store-operated second messenger signaling: variations on a theme"
9:30 am - 9:45 am Discussion
9:45 am - 9:55 am Dermot Cooper (Cambridge, UK)
"Exploring Calcium and cAMP dynamics in a Calcium-sensitive adenylyl cyclase microdomain"
9:55 am - 10.00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am David Yule (University of Rochester)
"InsP3 receptors; subtype specific regulation of Ca2+ release by ATP"
10:55 am - 11:10 am Discussion
11:10 am - 11:30 am Late Breaking Science Talk: Gyorgy Hajnoczky (Thomas Jefferson University)
11:30 am - 11:40 am Discussion
11:40 am - 12:00 pm Late Breaking Science Talk: Sandip Patel (University College London)
“Essential requirement for two pore channel 1 in NAADP-mediated calcium signalling”
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 2
5:30 pm - 7:30 pmCOMPARATIVE PHYSIOLOGY OF CALCIUM SIGNALS
5:30 pm - 5:35 pm Discussion Leader: Mike Berridge (The Babraham Institute)
"Introduction"
5:35 pm - 6:00 pm Alex Webb (University of Cambridge)
"Circadian Regulation of Calcium Signaling in Arabidopsis"
6:00 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm Luigia Santella (Stazione Zoologica Anton Dohrn)
"Actin cytoskeleton modulates calcium signaling in starfish oocytes"
6:40 pm - 6.55 pm Discussion
6:55 pm - 7:05 pm Gaiti Hasan (TIFR, Bangalore, India)
"Intracellular Ca2+ release and Store-operated Ca2+ entry are required for Drosophila flight"
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:20 pm Myriam Charpentier (Norwich, UK)
"Arbuscular mycorrhiza and Nod factor induced nuclear-localized calcium oscillations: identifying the calcium channel"
7:20 pm - 7:25 pm Discussion
7:25 pm - 7:30 pm General Discussion
7:30 pm - 8:00 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDOWNSTREAM FROM CA2+ SIGNALING - THE PHILOSOPHY OF CALCIUM SENSORS
9:00 am - 9:05 am Discussion Leader: Robert Burgoyne (The University of Liverpool)
"Introduction"
9:05 am - 9:30 am Mitsu Ikura (University of Toronto)
"Structural insights into STIM1-mediated initiation of store-operated calcium entry"
9:30 am - 9:45 am Discussion
9:45 am - 9:55 am Talk Selected From Posters (TBA)
9:55 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Annete Draeger (University of Bern)
"Dynamic regulation of ceramide platforms by intracellular calcium"
10:55 am - 11:10 am Discussion
11:10 am - 11:35 am David Yue (The John Hopkins University School of Medicine)
"Novel mechanisms underlying smart Ca2+ decoding by the CaM/Ca channel complex"
11:35 am - 11:50 am Discussion
11:50 am - 12:10 pm Late Breaking Science Talk: Ilya Bezprozvanny (UT Southwestern medical centre at Dallas)
"Presenilins and calcium signaling in mouse models of AD"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm General Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session 2
5:30 pm - 7:30 pmKEYNOTE LECTURE AND FINAL DISCUSSION
5:30 pm - 5:40 pm Discussion Leader: Ole Petersen (The University of Liverpool)
"Introduction"
5:40 pm - 6:40 pm Tobias Mayer (Stanford University)
"Ca2+ signaling from the endoplasmic reticulum to the plasma membrane"
6:40 pm - 7:00 pm Discussion
7:00 pm - 7:30 pm General Discussion (any topic of the conference)
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by 1 R13 CA147843-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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