Gordon Research Conferences
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Conference Program
 
Collagen
The Functional Continuum of Cells and Matrix
July 19-24, 2009
Colby-Sawyer College
New London, NH

The Collagen Gordon Research Conference has convened biennially for the last 38 years and will continue to present cutting-edge research on a wide range of topics on structure, biology and pathology of collagens and their ligands in development, tissue homeostasis and pathology. The meeting program reflects the complexity of the collagen genome, the diversity of the collagen proteome and its functions, variations that result from physiological alterations, and consequences of collagen mutations. The conference will continue to recognize the central roles of collagens in their macromolecular context in a wide variety of matrices in all organs and their instructive roles that govern cell functions, including stem cells. Special focus will be on recent developments on molecular and cell-based therapies of collagen diseases. The Conference will bring together investigators who are at the forefront of the field, and will provide opportunities for junior scientists and graduate students to present their work in poster format or short talks and exchange ideas with leaders in the field. All meeting attendees are encouraged to present their work in poster format at the meeting. There will be two poster sessions for this purpose. You are welcome to provide a title and bring a poster even if you did not submit an abstract at the time of application. The primary objective is to provide a forum for the presentation and discussion of recent contributions at the leading edge of the field.

We look forward to seeing you in New London!


Contributors
FibroGen, Inc.
Gordon Research Conferences
NIH / National Institute of Arthritis and Musculoskeletal and Skin Diseases
American Association of Anatomists
Medical University of South Carolina
Green Mountain Antibodies

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBiosynthesis and Regulation of Collagens
7:40 pm - 7:50 pmDiscussion Leader: Johanna Myllyharju (Oulu, Finland)
"Introduction"
7:50 pm - 8:15 pmHank Qi (Boston)
"Hydroxylation and Functional Impact of Human Argonaute 2 by Collagen Prolyl-4 Hydroxylase"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmHans Peter Bächinger (Portland)
"The P3H1/CRTAP/CypB Complex Has Multifunctional Roles in Collagen Biosynthesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLarry Luchsinger (Boston)
"The Protein Arginine Methyltransferase (PRMT5) Associates with Class II Transactivator (CIITA) to Repress Collagen Transcription"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPaul Nerenberg (Cambridge)
"Partial Unfolding of the alpha2 chain in Type I Collagen as a Mechanism for Collagen Degradation"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Collagen Assembly
Discussion Leader: Hans-Peter Bächinger (Portland)
9:00 am - 9:25 amSergei Boudko (Portland)
"Trimerization Domains of Collagens"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amYujia Xu (New York)
"Local Stability and the Conformational Changes of OI Mutations - a Look beyond the Propensity Scale"
10:05 am - 10:20 amDiscussion
10:20 amCoffee Break / Group Photo
10:50 am - 11:15 amJeff Hartgerink (Houston)
"Design and Self-Assembly of Heterotrimeric Collagen Helices"
11:15 am - 11:30 amDiscussion
11:30 am - 11:45 amJoseph Orgel (Chicago)
"Collagen Fibril and Decorin Core Protein: Structure and Location of Interaction Sites"
11:45 am - 11:50 amDiscussion
11:50 am - 12:15 pmTaina Pihlajaniemi (Oulu, Finland)
"Structural and Regulatory Roles of Endostatin Collagens at the Basement Membrane Zone"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCollagen Receptors
7:30 pm - 7:50 pmDiscussion Leader: Ambra Pozzi (Nashville)
"Overview on Collagen Binding Receptors and Their Cellular Functions"
7:50 pm - 8:10 pmThomas Bugge (Bethesda)
"Collagen Remodeling in Tissue Development and Pathogenesis: the Endocytic Receptor uPARAP/Endo180"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmJohanna Jokinen (Turku, Finland)
"Integrin alpha2beta1, a Collagen Receptor, Activates p38 MAP Kinase and PKC with Different Mechanisms"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmBirgit Leitinger (London)
"How Discoidin Domain Receptors Interact with Collagen"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBrooke Russell (Houston)
"Prokaryotic Derived Collagen Like Proteins Demonstrate Specificity for Integrin Interactions"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCollagen Suprastructures and ECM Ligand Interactions
9:00 am - 9:10 amDiscussion Leader: David Birk (Tampa)
"Introduction"
9:10 am - 9:35 am Peter Bruckner (Muenster, Germany)
"Matrix Suprastructures: How the Same Proteomic Stars Play Distinct Games"
9:35 am - 9:45 am Discussion
9:45 am - 10:00 am James San Antonio (Malvern)
"Transforming the Two-Dimensional Collagen Map to the Living Fibril"
10:00 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 11:00 am Ake Oldberg (Lund, Sweden)
"SLRPs Modulate Collagen Structure and Function"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 am Michael Yu (Baltimore)
"Spatio-Temporal Modification of Collagen Scaffolds Mediated by Collagen Mimetic Peptides"
11:35 am - 11:45 am Discussion
11:45 am - 12:00 pm Florence Ruggiero (Lyon)
"Collagen XXII is Required for Muscle Cell Attachment to Myoseptal Tendon in Zebrafish"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:20 pm Karl Kadler (Manchester, UK)
"Towards an understanding of fibripositors - mechanosensors, 3D matrix adhesion or collagen-fibronectin fibrillogenesis sites?"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmER Stress and Quality Control of Collagens
7:30 pm - 7:45 pmDiscussion Leader: John Bateman (Melbourne, Australia)
"Introduction"
7:45 pm - 8:10 pmRay Boot-Handford (Manchester, UK)
"Targeted ER Stress Induces Chondrodysplasia"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmKathy Cheah (Hong Kong)
"Alleviating ER Stress in Chondrocytes: Molecular Strategies and the Developmental Cost of Recovery"
8:50 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pm Tom Van Agtmael (Glasgow, UK)
"Spectrum of Phenotypes in Col4a1 Mutant Mice Includes Hypotension and Vasodilation Defects"
9:15 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFibroblasts and ECM Mechanoreception
9:00 am - 9:10 amDiscussion Leader: Boris Hinz (Toronto, Canada)
"Introduction: Mechanics Matter"
9:10 am - 9:35 amPaul Janmey (Phildelphia)
"Matrix Stiffness: Integrating Cell Responses to Mechanical Stimuli"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amJoachim Spatz (Stuttgart, Germany)
"How Fibroblasts Feel and Respond to Nano-Topographies"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amMelody Swartz (Lausanne, Switzerland)
"Mechanical Cues in Three-Dimensional Collagen Matrices"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amKristofer Rubin (Uppsala, Sweden)
"Structure-Function Relationships in Carcinoma Stroma"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmLysianne Follonier-Castella (Lausanne, Switzerland)
"Calcium-Dependent Micro-Contractile Events in Myofibroblasts: Evidence for a Lock-Step Mechanism of Matrix Remodeling"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFunctions of ECM in Stem Cell Niches
7:30 pm - 7:45 pmDiscussion Leader: Marion Young (Bethesda)
"Introduction: Stem Cell Properties"
7:45 pm - 8:05 pmXiao-Dong Chen (San Antonio)
"Reconstitution of Marrow-Derived Extracellular Matrix Ex Vivo: an Optimal Niche for Retaining Properties of Mesenchymal Stem Cells"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmSherrill Adams (Philadelphia)
"Decreased Type III Collagen Expression Impairs Mesenchymal Progenitor Cell Differentiation Toward Osteogenic and Chondrogenic Lineages and Alters Skeletal Development"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmJennifer Elisseeff (Baltimore)
"Biosynthetic Materials for Guiding Cel l and Tissue Repair"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmChing-Yan C. Yeung (Manchester, UK)
"Human Mesenchymal Stem Cells in Linear 3D Fibrin Gels Synthesize an Extracellular Matrix Similar to Embryonic Tendon"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCollagen and ECM Diseases and Novel Therapeutic Strategies
9:00 am - 9:10 amDiscussion Leader: Danny Chan (Hong Kong)
"Brief overview"
9:10 am - 9:30 amDoug Gould (San Francisco)
"Pleiotropism of Col4a1 Mutations Include Hallmarks of Muscle-Eye-Brain Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amAntti Salo (Oulu, Finland)
"LH3 Mutations in a Human Connective Tissue Disease"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amCassian Sitaru (Freiburg, Germany)
"Autoimmunity Against Collagens of the Epidermal Basement Membrane"
10:20 am - 10:25 amDiscussion
10:25 amCoffee Break
10:45 am - 11:05 amManuel Koch (Cologne, Germany)
"Skeletal Phenotypes of Collagen XII / XIV Mutations in Mouse and Man"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amDan Greenspan (Madison)
"New Roles for Type V Collagen in Metabolism and Disease"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmMarkus Moser (Martinsried, Germany)
"The Tale of Kindlins"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJoan Marini (Bethesda)
"COL1 C-propeptide Cleavage Site Mutations Cause OI with Increased Bone Mineralization"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmHot Topics
Discussion Leader: Billy Hudson (Nashville)
7:30 pm - 7:50 pm Matthew Hoffman (Bethesda)
"MT2-MMP-dependent Release of NC1 Domains from Collagen IV Regulates Protease Expression and Epithelial Proliferation during Morphogenesis"
7:50 pm - 8:00 pm Discussion
8.00 pm - 8:20 pm Roberto Vanacore (Nashville)
"Identification of a Novel Sulfur Bond in the Hydroxylysine/Methionine Crosslink of Collagen IV"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Michael Fox (Richmond)
"Collagen XVII is required for Synapse Formation in the Mammalian Central Nervous System"
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm Leena Bruckner-Tuderman (Freiburg)
"Mechanisms of Fibroblast Cell Therapy for Dystrophic Epidermolysis Bullosa"
8:55 pm - 9.00 pm Discussion
9.00 pm - 9:10 pm Jarmo Käpylä (Turku)
"A Small Molecule Inhibitor of Integrin Alpha2Beta1 Introduces a New Strategy for Antithrombotic Therapy"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Nishad N. Fathima (Tamil Nadu)
"Structure and Hydration Dynamics of Collagen and its Influence on Adhesion and Dilation at Interfaces"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by (1 R13AR057213-01) from NIAMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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