Gordon Research Conferences
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Conference Program
 
Mammalian Gametogenesis & Embryogenesis
August 2-7, 2009
Waterville Valley Resort
Waterville Valley, NH
Chair:
Michael K. Skinner

Vice Chair:
Robert E. Braun

This is the 17th Gordon Conference on Mammalian Gametogenesis and Embryogenesis. This conference provides a unique and valuable opportunity for discussion and the exchange of ideas between clinicians devoted to delivering the most modern therapeutic approaches to their patients, and basic scientists who are examining the biological mechanisms that underlie normal and abnormal function of gametogenesis and embryogenesis. Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the continued survival of animal species in the 21st century and beyond. Advances in reproductive biology have immediate application on the treatment of human infertility and subfertility, in developing contraceptive methods and in novel approaches to wildlife preservation. Moreover, stem cells, pluripotent cells, gametes and early embryos provide important models for basic research aimed at understanding nuclear programming, cell cycle regulation, and transcriptional control mechanisms. The objective of the Conference is to provide a forum for the exchange of the latest advances in the field, as well as to promote discussion and debate by providing a relaxed setting that fosters interaction.

This conference will feature a program of the most active national and international researchers. Topics such as stem cell biology/therapy, assisted reproductive technologies, cloning, epigenetic reprogramming and systems biology, hold promise to be translated into significant new therapeutic approaches to treat diseases.

On Wednesday afternoon, there will be an informal Career Opportunities and Trainee Workshop. This career development session will be chaired by Robert Braun (Jackson Lab) and will feature informal discussion, questions and answers with Andrea Cupp (Nebraska), Kyle Orwig (University of Pittsburgh), and Andrew Kasarskis (Rosetta/Merck).


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmsRNA IN GAMETOGENESIS AND EMBRYOGENESIS
7:35 pm - 7:45 pm Discussion Leader: Haifan Lin (Yale)
"Introduction"
7:45 pm - 8:15 pm Wei Yan (University of Nevada Reno)
"Roles of Testicular MicroRNAs"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:50 pm Deborah Bourc'his (Institute Curie)
"Epigenetic Cooperation in Transposon Suppression in the Male Germ Line"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Haifan Lin (Yale)
"PIWI Proteins in Germline Stem Cell Division"
9:25 pm - 9:30 pm Discussion
9:30 pm Social
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSTEM CELLS: GERMLINE & EMBRYONIC
9:00 am - 9:10 am Discussion Leader: Erika Matunis (Hopkins)
"Introduction"
9:10 am - 9:40 am Wolfgang Engel (University of Gottingen)
"From Stem Cells to Male Germ Cells"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am Kyle Orwig (University of Pittsburgh)
"Stem Cells in the Male Germline"
10:15 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break / Group Photo
11:00 am - 11:30 am Michael Roberts (University of Missouri)
"The Transition from Human Embryonic Stem Cell to Trophoblast"
11:30 am - 11:35 am Discussion
11:35 am - 11:50 am Short Talk: Shau-Ping Lin (National Taiwan University)
"Genetic and epigenetic characterization of early germ cells isolated from ES cells via genetic selection"
11:50 am - 11:55 am Discussion
11:55 am - 12:10 pm Short Talk: Jiyoung Lee (Tokyo Medical and Dental University)
"Heritable imprinting defect caused by epigenetic abnormalities in spermatogonial stem cells"
12:10 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmEPIGENETIC PROGRAMMING DURING GAMETOGENESIS AND EMBRYOGENESIS
7:30 pm - 7:40 pm Discussion Leader: John McCarrey (University Texas San Antonio)
"Introduction"
7:40 pm - 8:10 pm Alex Meissner (Harvard)
"Genome-Wide Mapping of the Developing Stem Cell Epigenome"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Gavin Kelsey (Babraham Institute)
"Mechanisms of gametic imprint mark establishment"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Kevin Eggan (Harvard)
"Cell Biological Constraints on Reprogramming"
9:20 pm - 9:25 pm Discussion
9:30 pm Social
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmASSISTED REPRODUCTIVE TECHNOLOGIES AND STEM CELLS
9:00 am - 9:10 am Discussion Leader: Carmen Sapienza (Temple University)
"Introduction"
9:10 am - 9:40 am Derek McLean (Washington State University)
"Retinoic Acid Regulation of Spermatogonial Stem Cell Proliferation"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am Carmen Sapienza (Temple University)
"DNA Methylation and Gene Expression Differences in Children Conceived in Vitro Versus in Vivo"
10:15 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:20 am Kevin Sinclair (University of Nottingham)
"Assisted Reproductive Techniques and Pregnancy Outcome"
11:20 am - 11:25 am Discussion
11:25 am - 11:40 am Short Talk: Eric De Waal (University Texas, San Antonio)
"Germline-specific epigenetic reprogramming in ICSI mice"
11:40 am - 11:45 am Discussion
11:45 am - 12:05 pm Short Talk: Mellissa Mann (University Western Ontario)
"Susceptibility of genomic imprinting to assisted reproductive technologies"
12:05 pm - 12:10 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmINTEGRATED GENOMICS AND EPIGENETICS
7:30 pm - 7:40 pm Discussion Leader: Marisa S. Bartolomei (U Penn)
"Introduction"
7:40 pm - 8:10 pm Minoo Rassoulzadegan (Inserm, Nice)
"Paramutation Mechanisms and Role in Development"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Philippe Arnaud (CNRS Montpelllier FR)
"Germline-Dnmt3L independent acquisition of imprints in the mouse"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Marisa S. Bartolomei (U Penn)
"Epigenetics and Imprinting Control Regions"
9:20 pm - 9:25 pm Discussion
9:30 pm Social
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGONADAL DEVELOPMENT AND SEX DETERMINATION
9:00 am - 9:10 am Discussion Leader: Andrea Cupp (Nebraska)
"Introduction"
9:10 am - 9:40 am Andrew Sinclair (Melbourne)
"Copy Number Variation Analysis of Patients With Disorders of Sexual Development: New Insights into Gonad Development and Dysfunction"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am David Page (Whitehead)
"Meiotic Initiation: How Germ Cells Decide to Go Haploid"
10:15 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:20 am Blanche Capel (Duke)
"Battle of the Sexes: Patterning the Gonad"
11:20 am - 11:25 am Discussion
11:25 am - 11:40 am Short Talk: Sergei Tevosian (Dartmouth)
"Conditional Ablation of Gata4 and Fog2 Genes in Mice Reveals their Distinct Roles in Mammalian Sexual Differentiation"
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm Short Talk: Yukiko Yamazaki (Unversity Hawaii)
"Direct effect of retinoic acid on entry into meiosis in male germ cells"
12:00 pm - 12:05 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmGENE NETWORKS AND TRANSCRIPTIONAL REGULATION
7:30 pm - 7:40 pm Discussion Leader: Miles Wilkinson (University California San Diego)
"Introduction"
7:40 pm - 8:10 pm Bill Kelly (Emory University)
"Transcriptional Networks in Germ Cell Development"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Miles Wilkinson (University of California at San Diego)
"Rhox Gene Networks"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Andrew Kasarskis (Rosetta / Merck)
"Gene Network Identification in Development and Disease"
9:20 pm - 9:25 pm Discussion
9:30 pm Social
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmENVIRONMENTAL IMPACTS ON EMBRYOGENESIS AND DEVELOPMENT
9:00 am - 9:10 am Discussion Leader: Pat Hunt (Washington State University)
"Introduction"
9:10 am - 9:40 am Robert Waterland (Baylor College of Medicine)
"How Does Maternal Nutrition Affect Developmental Epigenetics in the Early Embryo?"
9:40 am - 9:45 am Discussion
9:45 am - 10:15 am Pat Hunt (Washington State University)
"Environmental Factors That Make a Good Egg Go Bad"
10:15 am - 10:20 am Discussion
10:20 am - 10:50 am Coffee Break
10:50 am - 11:20 am Emma Whitelaw (Queensland Inst, Australia)
"Environmental Effects on Epigenetic Programming"
11:20 am - 11:25 am Discussion
11:25 am - 11:40 am Short Talk: Dan Rappolee (Wayne State)
"Stress and stress enzymes cause developmental and homeostatic effects in embryos and stem cells"
11:40 am - 11:45 am Discussion
11:45 am - 12:00 pm Short Talk: Carlos Guerrero-Bosagna (Washington State University)
"Epigenetic transgenerational actions of the endocrine disruptor vinclozolin on the rat male germ line"
12:00 pm - 12:05 pm Discussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmFOUNDER'S FORUM / KEYNOTE LECTURES
Discussion Leader: MaryAnn Handel (Jackson Lab)
7:30 pm - 8:00 pm Eva Eicher (Jackson Lab)
"Genetics and Sex Determination"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Janet Rossant (University of Toronto)
"From Embryo to Stem Cell and Back Again"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm John Eppig (Jackson Lab)
"Role of the Egg in the Ovary and Development"
9:20 pm - 9:30 pm Discussion
9:30 pm Social
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Funding for this conference was made possible (in part) by Grant 1 R13 HD61110-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Environmental Health Sciences (NIEHS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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