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Biocatalysis (GRS)
Gordon Research Seminar

Dates

July 7-8, 2012

Location

Bryant University
Smithfield, RI

Organizers

Chair:
Helge Jochens

Associate Chair:
Aram Panay

Meeting Description

The Gordon Research Seminar on Biocatalysis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is on the new trends in biocatalysis and protein engineering with emphasis on the applicability of the knowledge generated in academia to improve current industrial synthetic routes and generate greener technologies. Also, a discussion panel about career opportunities in the field of biocatalysis will be held to provide young scientists guidance in choosing long term carrier goals.

Related Meeting

This GRS was held in conjunction with the "Biocatalysis" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chairs (Helge Jochens/Aram Panay)
3:45 pm - 4:30 pmKeynote Address: Challenges and Opportunities in Microbial Biosynthesis
3:45 pm - 4:15 pm Kristala Jones-Prather (MIT, USA)
"Challenges and Opportunities in Microbial Biosynthesis"
4:15 pm - 4:30 pm Discussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 8:30 pmBiocatalysts with Novel Function
Discussion Leaders: Hans-Peter Mayer (Lonza AG, Switzerland) and Lucy Chappell (University of Leeds, UK)
7:30 pm - 7:50 pm Matthew Merski (UCSF, USA)
"Engineering a Model Protein Cavity to Catalyze the Kemp Elimination"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Ashley Daugherty (Emory University, USA)
"Circular Permutation of Old Yellow Enzyme: In Vitro Characterization of a Complete Synthetic Library"
8.20 pm - 8.30 pm Discussion
8:30 pm - 9:30 pmDiscussion Panel: Careers in Biocatalysis
Moderator: Stefan Lutz (Emory University, USA)
Panelists: Kristala Jones-Prather (MIT, USA), Gjalt Huisman (Codexis, USA) and Catherine Goodman (Senior Editor, Nat. Chem. Biol.)
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amGreen Chemistry - Biocatalysts at Work
Discussion Leaders: Stefan Lutz (Emory University, USA) and Marta Pontini (University of Manchester, UK)
9:00 am - 9:20 am Michael Fink (Vienna Institute of Technology, Austria)
"A Chemo-Enzymatic Cascade Process for Single-Operation Synthesis of Chiral Aroma Lactones"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Nadine Ladkau (Technical University Dortmund, Germany)
"Specific Terminal Oxy- and Aminofunctionalization of Dodecanoic Acid Methyl Ester Coupled in a Single Whole-Cell Catalyst"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Daniela Quaglia (University College Dublin, Ireland)
"A Classic Oxidoreductase with a Modern Twist"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Maria Villegas Torres (University College London, UK)
"Design and Characterisation of a Multi-modular Enzymatic Expression System for De Novo Synthesis of Chiral Amino Alcohols"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:45 pmPutting the Rational back into Biocatalysis
Discussion Leaders: Gjalt Huisman (Codexis, USA) and Hein J. Wijma (University of Groningen, Netherlands)
1:30 pm - 1:50 pm Sebastian Bartsch (University of Groningen, Netherlands)
"Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase"
1:50 pm - 1:55 pm Discussion
1:55 pm - 2:15 pm Sabrina Kille (Max-Planck Institute für Kohleforschung, Germany)
"Find your Hit faster"
2:15 pm - 2:20 pm Discussion
2:20 pm - 2:40 pm Panwajee Payongsri (University College London, UK)
"Directed Evolution of Transketolase to Access Aromatic Dihydroxy Ketones Towards the Synthesis of Novel Antibiotics"
2:40 pm - 2:45 pm Discussion
2:45 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.
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