The Gordon Research Seminar on Protein Folding Dynamics is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of this meeting is on the latest theoretical and experimental advances in protein folding. The program will include keynote lectures and discussions led by senior scientists, and research talks from graduate students and postdocs covering a wide variety of topics, among them: techniques and interpretation of single-molecule experiments, misfolding and aggregation, evolutionary principles of protein design, and the role of protein dynamics and allostery in molecular machines and signaling pathways.
This GRS was held in conjunction with the "Protein Folding Dynamics" Gordon Research Conference (GRC)
. Refer to the associated GRC program page
for more information.
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Presentation|
|3:45 pm - 4:15 pm||Matthias Rief (Technical University of Munich)
"Single molecule dynamics of proteins under load"
|4:15 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session I|
|7:30 pm - 9:30 pm||Protein folding dynamics at the single molecule level|
|Discussion Leaders: Matthias Rief (Technical University of Munich) and Peng Zheng (University of British Columbia)
|7:30 pm - 7:46 pm||Mehdi Damaghi (ETH Zurich)
"Folding mechansim of a beta barrel protein in the membrane"
|7:46 pm - 7:54 pm||Discussion|
|7:54 pm - 8:10 pm||Armin Hoffmann (University of Alberta)
"Folding dynamics from single-molecule trajectories using signal-pair correlation analysis"
|8:10 pm - 8:18 pm||Discussion|
|8:18 pm - 8:34 pm||Yann von Hansen (Technical University of Munich)
"Extracting protein dynamics from single-molecule experiments using dynamic deconvolution"
|8:34 pm - 8:42 pm||Discussion|
|8:42 pm - 8:58 pm||Andrea Soranno (University of Zurich)
"Quantifying internal friction in unfolded and intrinsically disordered proteins"
|8:58 pm - 9:06 pm||Discussion|
|9:06 pm - 9:22 pm||Hoi Sung Chung (National Institutes of Health)
"Measurement of average transition-path time for protein folding in single molecule FRET experiments"
|9:22 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Protein aggregation|
|Discussion Leaders: Sheena Radford (University of Leeds) and Steven Plotkin (University of British Columbia)
|9:00 am - 9:16 am||Priyanka Narayan (University of Cambridge)
"A generic mechanism of action of small, ATP-independent chaperones on the aggregation and toxicity of amyloid-beta oligomers"
|9:16 am - 9:24 am||Discussion|
|9:24 am - 9:40 am||Yu-Shan Lin (Stanford University)
"Investigating how peptide length and a pathogenic mutation modify the structural ensemble of amyloid beta monomer"
|9:40 am - 9:48 am||Discussion|
|9:48 am - 10:04 am||Adam Trexler (Yale University)
"Probing the effects of the cellular environment on alpha-synuclein structure"
|10:04 am - 10:12 am||Discussion|
|10:12 am - 10:28 am||Patricia Faisca (University of Lisbon)
"Identification and structural characterization of a common aggregation-prone intermediate in the folding pathways of spc-SH3 amyloidogenic variants"
|10:28 am - 10:36 am||Discussion|
|10:36 am - 10:52 am||Zhiping Jiang (National Institutes of Health)
"Effects of membrane lipids on the conformation and aggregation of the repeat domain of a functional amyloid, Pmel17"
|10:52 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:42 pm||Theory and simulations of protein folding and function|
Edward O'Brien (University of Cambridge) and Zhechun Zhang (University of Maryland)
|1:30 pm - 1:46 pm||David de Sancho (University of Cambridge)
"Matching theory and experiment for primary peptide folding"
|1:46 pm - 1:54 pm||Discussion|
|1:54 pm - 2:10 pm||Govardhan Reddy (University of Maryland)
"The folding mechanism of green fluorescent protein"
|2:10 pm - 2:18 pm||Discussion|
|2:18 pm - 2:34 pm||Andrea Kravats (University of Cincinnati)
"Probing the coupling between intra-ring allostery of the ClpY nanomachine and translocation of a substrate protein"
|2:34 pm - 2:42 pm||Discussion|
|2:42 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|