Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Techniques in Folding Dynamics
Discussion Leader: Prajna Mishra (University of Pennsylvania, Philadelphia, United States)
3:45 pm - 3:55 pm
Chi-Jui Feng (National Institutes of Health, United States)
"Measuring Transition Paths of Fast Folding Proteins by Single-Molecule FRET and Zero-Mode Waveguides"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Allan Ferrari (Northwestern University, United States)
"Large Scale Investigation of Protein Stability and Dynamics Using High-Throughput Hydrogen-Deuterium Exchange Mass Spectrometry"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Justin Miller (University of Pennsylvania, United States)
"msmFRET Enables Comparison of MD and smFRET Datasets to Understand Conformational Heterogeneity Within Individual smFRET Populations"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Engineering and Design
Discussion Leader: Darian Yang (University of Pittsburgh, United States)
7:30 pm - 7:40 pm
Aditi Konar (Indian Institute of Science Education and Research, India)
"Role of a Calcium Binding Site Across Glycoside Hydrolase(GH) 9 Family Endoglucanases"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Albert Escobedo (CRG - Centre for Genomic Regulation, Spain)
"The Genetic Architecture of Hydrophobic Protein Cores"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Samuel Thompson (Stanford University, United States)
"Expanding Protein Engineering with Proteins that Fold and Function in Water-Immiscible Solvents"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Philipp Heckmeier (University of Zurich, Switzerland)
"A Billion Years of Evolution Manifest in Nanosecond Protein Dynamics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Fernando Bruno da Silva (University of Warsaw, Poland)
"Insights into the Degradation and Structural Dynamics of the First Crystal Double Knotted Protein TrmD-Tm1570 from Calditerrivibrio Nitroreducens"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Lee Schnaider (University of California, San Francisco, United States)
"Probing the Rules of Protein Structure, Function and Recognition Through the De Novo Design of Functional Proteins"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Andrew Savinov (Massachusetts Institute of Technology, United States)
"High-Throughput Discovery of Inhibitory Protein Fragments with AlphaFold"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Protein Interactions and Dynamics
Discussion Leader: Brant Gracia (The University of Texas MD Anderson Cancer Center, United States)
9:00 am - 9:10 am
Junlang Liu (Harvard University, United States)
"How Does GroEL Recognize Targeted Proteins?"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Renee Hastings (Stanford University, United States)
"Conformational Ensembles Determine Selectivity in Prthologous Transcription Factors"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Yumin Lee (University of Chicago, United States)
"Unveiling the Dynamics of Binding and Folding in Ribonuclease S Formation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Ari Selzer (University Of Pittsburgh School Of Medicine, United States)
"Small Molecule Allosteric Modulators of the AML-associated Src-Family Kinase, Hck"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jules Berlin Nde Kengne (University of Washington, United States)
"Experiment and Simulations Reveal Residue Details for How Target Binding Tunes Calmodulin’s Calcium Binding Properties"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Kristine Kitoka (Latvian Institute of Organic Synthesis, Latvia)
"dGAE(297-391) tau Fragment Promotes Formation of CTE-Like Full-Length tau Filaments"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Jaie Woodard (University of Michigan, United States)
"Thermodynamic Stability Change Prediction and Topological Features of Protein Phosphorylation in Cancer"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Strategies for Navigating Academic Job Searches
Discussion Leader: Ian Sitarik (Pennsylvania State University, United States)
1:30 pm - 2:15 pm
Alex Guseman (University of California San Diego, United States), Shahar Sukenik (University of California, Merced, United States), Ellinor Haglund (University of Hawaii at Manoa, United States), Caitlin Davis (Yale University, United States) and Martin Gruebele (University of Illinois at Urbana-Champaign, United States)
"Strategies for Navigating Academic Job Searches"
2:15 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes