Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Pre-Malignancies and Early Stage Tumors
Discussion Leader: Mariella Filbin (Dana-Farber Cancer Institute/Boston Children's Hospital, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Joan Brugge (Harvard Medical School, United States)
"An Atlas of Early Stage Tumorigenesis In The Mammalian Breast"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Short Talk Selected from Poster Abstracts
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Elli Papaemmanouil (Memorial Sloan Kettering Cancer Center, United States)
"Genomic Alterations in Cancer Development"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Multi-Omic Analysis and Cellular Plasticity
Discussion Leader: Joan Brugge (Harvard Medical School, United States)
9:00 am - 9:20 am
Caleb Lareau (Memorial Sloan Kettering, United States)
"Single-Cell Multi-Omics Analyses of the Immune System"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Christina Leslie (Memorial Sloan Kettering Cancer Center, United States)
"Machine Learning for Single-Cell Regulatory Genomics and Cancer Biology"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Joseph Chan (Memorial Sloan Kettering Cancer Center, United States)
"Understanding Histological Switches Across Cancer Types"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Aurélie Ernst (German Cancer Research Center, Germany)
"Genomic Instability in Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Federico Gaiti (Princess Margaret Cancer Centre (University Health Network), Canada)
"Single-Cell Multi-Omics in Brain Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Kaile Wang (MD Anderson cancer center, United States)
"Dissecting Breast Cancer Evolution by Single-Cell Multi-Omics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Devon Lawson (University of California, Irvine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Perturbations and Single Cell Readouts
Discussion Leader: Devon Lawson (University of California, Irvine, United States)
7:30 pm - 7:50 pm
System.String[]
"Characterizing Cell-Intrinsic and Microenvironmental Drivers of Cell State, Plasticity, and Drug Response in Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Tuomas Tammela (Memorial Sloan Kettering Cancer Center, United States)
"Functional Interrogation of Cancer Cell States in Solid Tumors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jellert Gaublomme (Columbia University, United States)
"CRISPRmap: In Situ Pooled Screens for Multimodal Single-Cell Cancer Biology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Weiyi Peng (University of Houston, United States)
"Revealing Mechanisms of Tumor Immune Evasion by High-Throughput Genetic Screens"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Ecosystems and Microenvironments
Discussion Leader: Ken Chen (University of Texas MD Anderson Cancer Center, United States)
9:00 am - 9:20 am
Mariella Filbin (Dana-Farber Cancer Institute/Boston Children's Hospital, United States)
"Single-Cell Genomic Analyses of Pediatric Brain Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kai Tan (University of Pennsylvania, United States)
"Single Cell Muti-Omics in Leukemia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Livnat Jerby (Stanford University, United States)
"Immune Evasion and Spatial Organization of Ovarian Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Olli Dufva (Wellcome Sanger Institute, United Kingdom)
"Genomic Determinants of Anti-Cancer Immunity Using Organoid Models"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Priscilla Brastianos (Massachusetts General Hospital, United States)
"Single-Cell Analysis of Brain Metastasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Spatial Technologies
Discussion Leader: Jellert Gaublomme (Columbia University, United States)
7:30 pm - 7:50 pm
Sanja Vickovic (New York Genome Center, Columbia University, SciLifeLab, United States)
"Deciphering Tissue Pathogenesis With Spatial Sequencing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jean Fan (Johns Hopkins University, United States)
"Comparative Spatial Omics Analysis Across Length Scales"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jackson Weir (Harvard University, United States)
"Spatial Genomic Analysis With Slide-Tags"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immune Recognition in Cancer
Discussion Leader: Caleb Lareau (Memorial Sloan Kettering, United States)
9:00 am - 9:20 am
Benjamin Greenbaum (Memorial Sloan Kettering Cancer Center, United States)
"Deciphering Self vs Non-Self at the Tumor-Immune Interface"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Bradley Bernstein (Harvard University / Dana Farber Cancer Institute, United States)
"High-Throughput Epigenomic Analysis in Single-Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kellie Smith (Johns Hopkins University, United States)
"Immunogenomic Determinants of Response and Resistance to PD-1 Blockade"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Nir Hacohen (Massachusetts General Hospital, United States)
"Decoding Immune-Cancer Interactions by Single-Cell Genomics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Linghua Wang (The University of Texas MD Anderson Cancer Center, United States)
"Evolution of Immune and Stromal Cell States and Ecotypes During Gastric Adenocarcinoma Progression"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Methods
Discussion Leader: Jean Fan (Johns Hopkins University, United States)
7:30 pm - 7:50 pm
Ben Raphael (Princeton University, United States)
"New Algorithms for Spatial Omics Analysis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Joshua Campbell (Boston University School of Medicine, United States)
"A Novel Meta-Analysis Approach for Detecting Gene Programs in Lung Cancer Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Luca Pinello (Massachusetts General Hospital /Harvard Medical School/BROAD, United States)
"Learning Gene Regulatory Circuits and Cell Fate Decisions from Single-Cell Multi-Omics Data"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Pablo Camara (University of Pennsylvania, United States)
"Deconvolving Cellular Plasticity From Bulk Tumor Tissues"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genetic Evolution and Therapeutic Resistance
Discussion Leader: Nicholas Navin (University of Texas MD Anderson Cancer Center, United States)
9:00 am - 9:20 am
Roel Verhaak (Yale University, United States)
"Longitudinal Single-Nucleus Sequencing of IDH-Mutant Gliomas"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Timour Baslan (University of Pennsylvania, United States)
"Genomic Evolution of Aneuploidy at Single Cell Resolution"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Andrea Sottoriva (Human Technopole, Italy)
"Measuring Epigenetic Evolution and Cell Plasticity in Patient-Derived Organoid Models of Colorectal Cancer Under Treatmen"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Charles Rudin (Memorial Sloan Kettering Cancer Center, United States)
"Plasticity Mediated Drug Resistance in Lung Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Peter Van Loo (The University of Texas MD Anderson Cancer Center, United States)
"Molecular Archeology of Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
James Black (Francis Crick Institute, United Kingdom)
"Genetic and Non-Genetic Clonal Diversity in Cancer Evolution"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Invasion and Metastasis
Discussion Leader: Andrea Sottoriva (Human Technopole, Italy)
7:30 pm - 7:50 pm
Karuna Ganesh (Memorial Sloan Kettering Cancer Center, United States)
"Molecular Determinants of Drug Resistance and Metastasis in Colon Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Adrienne Boire (Memorial Sloan Kettering Cancer Center, United States)
"Capturing Cancer Cell-Microenvironmental Dynamics Within the Leptomeninges: From Bench to Bedside"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ashley Laughney (Weill Cornell Medicine, United States)
"Tackling the Genotype-To-Phenotype Problem in Cancer Evolution: A Focus on STING Signaling"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure