SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GENE THERAPY: WHAT ARE THE CHALLENGES? |
| Discussion Leader: Savio Woo (Mt. Sinai)
|
7:30 pm - 7:55 pm | Savio Woo (Mt. Sinai)
"Challenges for Gene Therapy of Cancer" |
7:55 pm - 8:20 pm | Ronald G. Crystal (Cornell Medical Center)
"Challenges to the Design of Gene Therapy Clinical Trials" |
8:20 pm - 8:45 pm | Dusty Miller (Fred Hutchinson Cancer Research Center, Seattle , WA)
"Challenges for Gene Therapy of Lung Diseases" |
8:45 pm - 9:10 pm | Don Kohn (Childrens Hospital Los Angeles, School of Medicine)
"Stupid Vector Tricks" |
9:10 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DETERMINANTS OF VIRUS ATTACHMENT AND ENTRY: PROSPECTS FOR RETARGETING |
| Discussion Leader: David T. Curiel (University of Alabama) |
9:00 am - 9:25 am | David T. Curiel (University of Alabama)
"In-Vivo Tumor Targeting Using Adenoviruses" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Guoying Zhou (University of Chicago)
"Targeting Herpes Simplex Virus 1 for Treatment of Malignant Gliomas" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo (10:15) |
10:45 am - 11:10 am | Steve Russell (Mayo Clinic)
"What Stops Oncolytic Viruses from Destroying Tumors?" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | James Wilson (University of Pennsylvania)
"AAV Capsid Structure Drives Vector Biology" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Paul McCray (University of Iowa)
"Improved Transduction of Differentiated Airway Epithelia with Pseudotyped Lentiviral Vectors" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MECHANISM OF VECTOR TRAFFICKING AND PACKAGING |
| Discussion Leader: John Engelhardt (University of Iowa)
|
7:30 pm - 7:55 pm | Gabrielle Campedelli-Fiume (University of Bologna, Italy)
"Molecular Bases of HSV Entry and HSV Targeting to the HER-2/neu Receptor" |
7:55 pm - 8:20 pm | Xiao Xiao (University of Pittsburgh)
"Systemic Gene Delivery Using AAV Vectors" |
8:20 pm - 8:45 pm | Mark Kay (Stanford University)
"Designing Viruses to Fight Viruses" |
8:45 pm - 9:10 pm | Philip Leopold (Weill Medical College, Cornell University)
"Late Stages in Adenovirus Trafficking to the Nucleus" |
9:10 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MECHANISMS OF VECTOR PERSISTENCE |
| Discussion Leader: Luigi Naldini (Vita-Salute San Raffaele University Medical School, Milano) |
9:00 am - 9:25 am | Luigi Naldini (Vita-Salute San Raffaele University Medical School, Milano)
"Hematopoietic Stem Cell Gene Transfer in Tumor-Prone Mouse Models Uncovers Low Genotoxicity of Lentiviral Vector Integration" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Frederic Bushman (University of Pennsylvania School of Medicine)
"Retroviral DNA Integration" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | David Russell (University of Washington)
"Foamy Virus Vector Integration Sites and Transduction of Hematopoietic Stem Cells" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Nicola Philpott (Institute of Child Health, London)
"Development of Non-Integrating and Site-Specifically Integrating Lentiviral Vectors" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | R. Jude Samulski (University of North Carolina)
"Molecular Forms of AAV Vectors After in Vivo Delivery" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Christof von Kalle (Cincinnati Children’s Hospital)
"Effects and Side Effects: The Biology of Insertional Gene Transfer into Hematopoietic Stem and Progenitor Cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | VECTOR GENOME STRUCTURE AND TRANSGENE EXPRESSION |
| Discussion Leader: Bernard Roizman (University of Chicago)
|
7:30 pm - 7:55 pm | Bernard Roizman (University of Chicago)
"The First 30 Minutes in the Reproductive Life of Herpes Simplex Virus" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Steve Triezenberg (Michigan State University)
"Role of Host Cell Transcriptional Coactivators in Viral Gene Regulation During Herpes Simplex Virus Infection" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Michel Sadelain (Memorial Sloan-Kettering Cancer Center)
"Regulated Transgene Expression and RNA Interference in Hematopoietic Stem Cells" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | John Engelhardt (University of Iowa)
"Intracellular Trafficking of rAAV2" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IMMUNE RESPONSE TO VECTORS |
| Discussion Leader: Pedro Lowenstein (CSMC, Los Ángeles, CA) |
9:00 am - 9:30 am | Pedro Lowenstein (CSMC, Los Ángeles, CA)
"The Dynamics of T Cell-Mediated Modulation of Brain Transgene Expression from Viral Vectors: Cellular, Molecular and Anatomical Mechanisms" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Katherine High (Children’s Hospital of Philadelphia)
"Immune Responses to AAV Capsid and to F.IX in AAV-Mediated, Liver-Directed Gene Transfer" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
11:00 am - 11:30 am | Brian Brown (Telethon Institute for Gene Therapy) |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Hildegund Ertl (University of Pennsylvania)
"Innate and Adaptive Immune Responses to Chimpanzee-Origin Replication-Defective Adenovirus Vectors" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | OVERCOMING INNATE HOST DEFENSES |
| Discussion Leader: Matthew Weitzman (Salk Institute)
|
7:30 pm - 7:55 pm | Matthew Weitzman (Salk Institute)
"The Effect of Cellular DNA Repair Proteins on Virus Infection and Transduction" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Patrick Moore (University of Pittsburgh)
"KSHV Immunoevasion and Tumorigenesis" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Clodagh O’Shea (UCSF Cancer Center, San Francisco, CA)
"Exploiting the Overlap Between the Adenovirus and Tumor Growth Deregulation Programs for Cancer Target Discovery and Therapy" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Robert Kalejta (University of Wisconsin)
"Cellular Intrinsic Immunity Regulates Expression from the Human Cytomegalovirus Major Immediate Early Promoter" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ONCOLYTIC VECTOR BIOLOGY AND DESIGN |
| Discussion Leader: Steve Russell (Mayo Clinic) |
9:00 am - 9:30 am | Karen Mossman (McMaster University, Ca)
"Oncolytic Herpesviruses that Target Interferon Defects in Cancer Cells" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Andre Lieber (University of Washington)
"Challenges for Tumor Targeting with Adenovirus Vectors" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
11:00 am - 11:30 am | Roberto Cattaneo (Mayo Clinic)
"Oncolytic Measles Virases: The New Battlegrounds" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Matthias Gromeier (Duke University)
"Targeting Oncolytic Viruses at the Level of Translation Control" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | VECTOR PROMISING TECHNOLOGY AND APPLICATIONS |
| Discussion Leader: Mark Kay (Stanford University) and Katherine High (Children’s Hospital of Philadelphia)
|
7:30 pm - 7:50 pm | John Rossi (City of Hope Medical Center, CA)
"RNAi Gene Therapy for HIV-1 and the Problem of Resistance" |
7:50 pm - 8:10 pm | Jean Bennett (University of Pennsylvania/School of Medicine)
"Niche Targets for Gene Therapy" |
8:10 pm - 8:30 pm | Phil Gregory (Sangamo Sangamo BioSciences, Richmond, CA)
"Engineered Zinc-Finger Proteins - Editors of Genome Sequence and Function" |
8:30 pm - 8:50 pm | David Fink (University of Michigan)
"HSV-Mediated Gene Transfer to the Peripheral Nervous System" |
8:50 pm - 9:10 pm | Jeffrey Chamberlain (University of Washington)
"Efficacy of rAAV-Microdystrophin Delivery to Young and Old Dystrophic Mice" |
9:10 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |