SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:00 pm | Keynote Lecture |
7:40 pm - 8:40 pm | Sir Gordon Duff (University of Sheffield School of Medicine)
"The Future Safety of Clinical Trials of Innovative Medicines" |
8:40 pm - 9:00 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitochondrial Toxicity |
| Discussion Leader: Yvonne Will (Pifzer, LaJolla, CA) |
9:00 am - 9:10 am | Yvonne Will (Pfizer, Inc)
"Introduction to Drug induced mitochondrial Toxicity" |
9:10 am - 9:55 am | James Lemasters (University of North Carolina Chapel Hill)
"Mitochondrial Toxicity Related Liver Injury" |
9:55 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 11:15 am | Kendal Wallace (University of Minnesota Duluth)
"Mitochondrial Toxicity Related Cardiac and Muscle Injury" |
11:15 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | James Dykens (Pfizer, Inc.)
"New Assays-New Insights" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nanotechnology Applications in the Development of Therapeutics |
| Discussion Leader: Nakissa Sadrieh (FDA) |
7:30 pm - 8:15 pm | Martin Philbert (University of Michigan)
"Nanotechnology and Health: The good, the bad and the ugly" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Nakissa Sadrieh (FDA)
"FDA considerations for the regulation of nanomaterial-containing products" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Adverse Drug Reactions with Biological Therapeutics: Mechanisms and Testing Approaches |
| Discussion Leader: Janet Clarke (Biogen) |
9:00 am - 9:45 am | Ali Amirkhosravi (Florida Hospital Institute of Translational Research)
"Therapeutic Antibody-Induced Platelet Activation and Thrombosis" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:15 am | Janice Lansita (Biogen Idec)
"Preclinical Evaluation of a Species Restricted Monoclonal Antibody Therapeutic" |
11:15 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Noel Dybdal (Genentech, Inc)
"Trastuzumab and Cardiac Dysfunction" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel Molecular Targets and Implications for Toxicity Testing |
| Discussion Leader: Mary Jane Masson (NIH) |
7:30 pm - 8:15 pm | Celia Dominguez (MRSSI/CHDI, Inc)
"p38 MAP Kinase inhibitors: Many are Made, but Few are Chosen" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Eicke Latz (Univeristy of Massachusetts School of Medicine)
"How Toll Receptors Are Activated" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Drug-Induced Liver Injury: Mechanisms that involve the innate and adaptive immune responses |
| Discussion Leader: N. Kaplowitz (University of Southern California) |
9:00 am - 9:45 am | Neil Kaplowitz (Univeristy of Southern California)
"DILI: Lessons from the Acetaminophen Mouse Model" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:15 am | Cynthia Ju (University of Colorado)
"Role of Hepatic Macrophages in Drug-Induced Liver Injury" |
11:15 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Robert Roth (Michigan State University)
"Role of Inflammatory Stress in Susceptibility to Drug-induced Liver Injury" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Selected Abstracts for Oral Presentations |
| Discussion Leader: Kevin Park (University of Liverpool) |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Functional Genomic Approaches to Adverse Drug Reactions |
| Discussion Leader: Jim Stevens (Lilly Research Laboratories) |
9:00 am - 9:45 am | Guochon Liao (Roche Institute)
"Computational Genetics: Toward Understanding Drug Toxicity" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:15 am | Molly Bogue (Jackson Laboratory)
"The Mouse Phenome Project - Modeling Human Genetic Variability in Mice" |
11:15 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Richard Weinshilboum (Mayo Clinic)
"Pharmacogenomics: Clinical Applications of Functional Genomics to Adverse Drug Reactions" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Discussion Session: Adverse Drug Reactions - Which ones can we predict? |
7:30 pm - 8:15 pm | James Stevens (Lilly Research Laboratories)
"Preclincal Testing Perspectives" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Munir Pirmohamed (University of Liverpool)
"Clinical Perspectives" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |