Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Exploring Neural Mediators of Cue-Triggered Reward Seeking
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Exploring Neural Mediators of Cue-Triggered Reward Seeking"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Neural Circuitry of Excessive Alcohol Drinking and Other Maladaptive Behaviors
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Neurobiological Contributions to the Diagnosis, Prevention and Treatment of Alcohol Use Disorders: NIAAA Update"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Role of mPFC Neuronal Ensembles in Reward Seeking and Alcohol Addiction"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Ethanol Withdrawal Produces Opposing Synaptic Alterations of Prelimbic and Infralimbic Terminals in the Rat Basolateral Amygdala"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Dynorphin/Kappa Opioid Receptor Changes with Immediate and Long-Term Stress/Ethanol Exposure"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Alcohol Engages Dynorphin/Kappa Opioid Receptor Signaling in the Extended Amygdala to Alter Behavior"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"CRISPR-Cas9 Editing of Hypocretin (Orexin) Receptor Genes in Cell Type-Specific Extended Amygdala Neurons Modulating Alcohol Drinking and Withdrawal-Related Behavior"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Mechanisms in Alcohol Use Disorder
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Gins of Our Fathers: Intergenerational Epigenetic Effects of Alcohol"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Neuroepigenetics: The Next Evolution in the Molecular Basis of Alcoholism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Maternal and Paternal Lineage Contributions to Transgenerational Effects of Prenatal Alcohol Exposure"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Multi-Tissue DNA Methylation Analysis Implicates Both Pre-Existing Risk and Induced Effects of Chronic Alcohol Use"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol Effects on CNS Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Migration Defects and Enduring Behavioral Impairments in a Mouse Model of Prenatal Ethanol Exposure"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"From Germ Cells to Adolescence Brain, Alcohol Programs to Alter the Development of the Neuroendocrine Immune Brain"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Altered Spatial Coding by Hippocampal Place Cells Following Moderate Prenatal Alcohol Exposure"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Effect of Developmental Alcohol Exposure on Neuronal Plasticity and Multisensory Integration in the Cortex"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Ribosome Dysbiogenesis Is a Novel Apoptotic Effector in Alcohol-Exposed Neural Crest"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"The Influence of Age and Moderate Prenatal Ethanol Exposure on CRF1 Receptor Regulation of GABAergic Transmission Within the Central Amygdala in Sprague Dawley Males"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Molecular Gatekeepers of Alcohol Signaling
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"A Molecular Mechanism for Choosing Alcohol over a Natural Reward"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Role of BK Channels in the Behavioral Effects of Alcohol"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"New Molecular Regulators of Alcohol-Drinking Behaviors"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Limiting the Afterhyperpolarization Drives Heavy Alcohol Drinking"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vulnerability and Resilience to Alcoholism and Comorbid Affective Disorders
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Traumatic Stress Reactivity and Neural Mediators of Alcohol Drinking"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Endocrine, Genomic, and Cognitive Mediation of Vulnerability to Excessive Drinking in Monkeys"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Impaired Brain Reward Circuitry May Underlie Alcohol Drinking in a Rat Model of Schizophrenia and Co-Occurring Alcohol Use Disorder"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"From Mice to Men: Developing the Medial Prefrontal Cortex as a Translationally-Derived Biomarker for TMS Treatment Development"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"A Cortical Circuit Regulating Resilience to Compulsive-Like Alcohol-Seeking"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Social Isolation Stress Increases Kappa Opioid Receptor Sensitivity in the Nucleus Accumbens of Rats"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of the Cerebellum in Alcohol Use Disorder
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Alcohol and Behavioral State-Dependent Cerebellar Circuit Activity"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Two Faces of the Cerebellum in Alcoholism: Site of Damage and Source of Compensation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Reward Signaling in Cerebellar Granule Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Genetic Variation in Potentially Rewarding and Aversive Actions of Low [EtOH] in the Cerebellum"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
The Neurocircuitry of Motivated Behaviors
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Role of Oxytocin in Alcohol Reinforced Behaviors in Rats and Humans"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"From Humans to Mice: A Link Between Low Striatal D2 Receptors and the Stimulant and Sedative Effects of Ethanol"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Mapping Neural Circuits Important for Alcohol Reward Memories in Drosophila "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"The Role of Top-Down and Bottom-Up Neural Circuits in the Modulation of Binge Drinking"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Regulation of Motivated Behavior by Phasic Dopamine"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"AMPA Receptor Subunit Activity Within the BLA to AcbC Circuit Is Required for the Positive Reinforcing Effects of Alcohol"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Frontiers: Immune/Microbiome/Inflammasome Interactions in Alcohol Use Disorder
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Neuroimmune Regulation of Alcohol Consumption: Which Cells? Which Signals?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Paradoxical and Sexually Dimorphic Effects of Adolescent Alcohol Exposure on Neuroimmune Function"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Biobehavioral Effects of a Pharmacological Challenge with Exogenous Ghrelin in Alcohol-Dependent Individuals: Is the Ghrelin System a Potential Pharmacological Target for Alcohol Use Disorder?"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Implication of the Gut Microbiota in Behavioral Changes Linked to Alcohol Dependence: Mechanistic Approaches and Therapeutic Perspectives"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure