Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Alcohol Abuse and Addiction from Mice to Humans
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
"Decoding Neuromodulatory Circuits in Motivated Behaviors"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 9:20 pm
"50 Years of Neuroscience Research at NIAAA: From Membranes to Microcircuits (Allosterism, Hyperkatifiea and Allostasis)"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Neuropeptide Signaling in Alcohol-Related Behaviors
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Alcohol Adaptations of Stress Circuits and Impact on Motivation, Intake and Relapse"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"CeA Neurotensinergic Neurons in Alcohol Consumption"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Central Amygdala Somatostatin Selectively Reduces Binge-Like Ethanol Intake"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Role of Neuropeptides in Stress-Enhanced Alcohol Drinking and Relapse-Like Behavior"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Central Amygdala Dynorphin/Kappa Opioid Regulation of Alcohol Drinking"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"What's Driving Escalation of Alcohol Drinking? Evidence in Favor of the Crystallization Hypothesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"An Insular-BNST Circuit Regulates Negative Affect Associated with Stress and Alcohol Abstinence"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interoceptive Processing in Alcohol-Seeking
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Contribution of Insular Extracellular Matrix to Compulsive Alcohol Drinking"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Defining the Social in Models of Social Aspects of Alcohol Drinking and Dependence"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Interoceptive Effects of Low Dose Alcohol"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Effects of Adolescent Alcohol Exposure on Nociception and Amygdala Neurotransmission"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of Synaptic Plasticity in Making and Breaking Alcohol-Related Behaviors
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Molecular Mechanisms of Forgetting"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Persistent Reduction of Alcohol-Drinking Behavior by Optogenetic Induction of Corticostriatal Synaptic Plasticity in the Dorsomedial Striatum"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Knock-in Mice Expressing an Ethanol-Resistant GluN2A NMDA Receptor Subunit Show Altered Responses to Ethanol"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dorsal Striatal Inhibitory Microcircuit Plasticity Underlying Compulsive Alcohol Drinking"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Prenatal Ethanol Exposure Leads to Failure of Synaptic Maturation and Persistent Cognitive/Behavioral Deficits"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Synaptic Fingerprints of Alcohol's Effects on Dorsal Striatal Glutamatergic Transmission"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol Use Disorders and Endocannabinoid Signaling
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Losing Balance: Dysregulated Endocannabinoid Signaling in Stress and Addiction"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Targeting Endocannabinoid Synthesis to Reduce Alcohol Consumption"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Genetic Variants in the Endocannabinoid Pathway Are Associated with Sleep-Related Phenotypes in Alcohol Use Disorders"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Brain Imaging of Endocannabinoid Metabolism in Alcohol Use Disorder: PET Studies of the FAAH Probe [11-C]CURB"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Monitoring and Modulating the Brain: New Tools Focusing on Catecholamines
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
"A Cortical-Brainstem Circuit Predicts and Governs Compulsive Alcohol Drinking"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Computational Approaches to Visualizing Cortical Activity States in Alcohol Drinking"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Developmental Disruption of Locus Coeruleus-Norepinephrine Signaling Results in Phenotypes Relevant to Neurodevelopmental Disorders"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Preclinical and Clinical Evidence of Progressive Microstructural Damage, Altered Extracellular Space, and Dopamine Diffusion in Early Abstinence"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"A Novel Computational Framework for the Role of Dopamine in Learning and Memory"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"To Drink or Not(ch) to Drink: Molecular Mechanisms Through Which Alcohol Influences Memory in Drosophila "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress-Alcohol Interactions in the Control of Behavior
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Interactions of Stress and Alcohol Exposure in Kappa Opioid Receptor Mediated Anxiety-Like Behavior and Dopamine Dynamics in the Nucleus Accumbens"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Synaptic Changes Within the Rhesus Putamen that May Underlie a Bias Towards Sensory-Motor Action Patterns: Potential Role of Glucocorticoid Receptors"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Functional Dissection of Basolateral Amygdala Neural Circuits for Alcohol Seeking Behaviors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Identifying Functional Roles for Specific Neuropeptides and GABA Expressed in CRF Neurons of the Central Amygdala"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Cortical Function and Dysfunction in Compulsive Alcohol Seeking
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Manipulating Corticostriatal Circuits to Curtail Reward-Related Behaviour"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Neural Encoding in Medial Prefrontal Cortex During Aversion Resistant Drinking in Rodent Models of Alcohol Use Disorder"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Adolescent Alcohol Exposure Enhances Perineuronal Nets in the Medial Prefrontal Cortex and Impairs Fear Extinction Learning in Adulthood"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Oops... I Did It Again: Promising Cortical Targets for Decreasing Risky Drinking and Relapse with Transcranial Magnetic Stimulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Differential Engagement of the Dorsomedial Prefrontal Cortex and the Mediodorsal Thalamus During Alcohol Consumption"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"mTORC1 in the Orbitofrontal Cortex Contributes to Alcohol Seeking and Habit"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Involvement of Fronto-Cortical Sigma-1 Receptors in Alcohol-Induced Hyperalgesia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Signals Controlling Alcohol Intake
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Live Cell-Seq: A New Tool for Alcohol Study"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Alcohol Alters Exosome Content: Implications for the Neuroimmune Actions of Alcohol"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ethanol Modulation of Glutamate Presynaptic Function: Mechanisms and Consequences"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Under the Influence: How Ethanol Hijacks RNA-Binding Proteins to Change the Synaptic Landscape"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure