Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Keynote Lectures
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"Th17 at the Intersection of Alcohol Use Disorder and Organ Damage"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Forward Genetics of Fatty Liver Disease"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Alcohol and the Metabolic Syndrome
9:00 am - 9:20 am
"Combined Liver Insult of Alcoholic and Non-Alcoholic Liver Disease: Lessons from a Preclinical Model"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Differences in the Role of RIP3 and MLKL in Alcohol-Associated and Non-Alcohol Associated Liver Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Metabolic Reprogramming and Liver Repair"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Altered Lipoprotein Metabolism in Alcoholic Hepatitis: Egg or Chicken?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"CYP2B10 is Induced by Binge Ethanol and Protects against Ethanol-Induced Liver Injury"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Clinical Relevance of Underlying Genetics in Patients with High Alcohol Use and Cirrhosis: the GenomALC Study"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Bioactive Lipid Metabolites: Novel Therapeutic Targets and Potential Treatment Strategies in Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ethanol-Induced Stress in Hepatocytes Attenuates Lipophagy of Nascent Lipid Droplets at the Endoplasmic Reticulum Surface"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Age-Related Dysregulation of the Bile Acid-Gut Microbiome Axis in Response to Ethanol"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Acceleration of Alcoholic Tissue Damage during Aging: Role of Autophagy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Exploring Microglia Autophagic Flux Impairments as a Driver of Advanced Age and Ethanol Induced Neuroinflammation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Vascular Effects of Binge Drinking in Mid-life Adults"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Age-Dependent Induction of the NADase CD38 is Implicated in the Progressive Alcohol-Associated Liver Disease during Aging"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Deletion of Phosphatidylethanolamine Methyltransferase Disrupts One-Carbon Metabolism to Promote Alcohol-Induced and Age-Dependent Progression of Liver Injury"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome and Intestine-Derived Molecules
9:00 am - 9:20 am
"Intestinal Targets of Probiotic-Derived Extracellular Vesicles in Alcohol-Associated Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Goblet Cells and Goblet Cell-Associated Passages as Modulators of Intestinal Immunity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Intestinal Exosomes in Alcohol-Induced Liver Injury"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Cell-Based Therapy for Alcohol-Associated Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The Role of Sphingosine Kinase 2 and Gut-liver-Axis in Alcohol-Induced live injury"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Increased Gut Leakiness, Endotoxemia, and Acute Liver Injury in ALDH2-KO Mice after a Single Dose of Binge Alcohol through the Gut-Liver Axis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Candida Albicans-Apecific Th17 Cell-Mediated Response Contributes to Alcohol- Associated Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Regulation of Intestinal IgA by Functional Hepatic pIgR is Required to Reduce Bacterial Overgrowth and Limit Ethanol-Induced Liver Disease in Mice."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunity and Infections: Implications for Diseases Associated with Alcohol
7:30 pm - 7:50 pm
"Alcohol, Lung Injury and COVID-19"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Alcohol-Related Lung Infection via Gut-Lung Axis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The 'Ins' and 'Outs' of Anaphylatoxins in Alcohol-Associated Liver Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mincle-GSDMD Mediated Release of IL-1ß/IL-18 Containing sEVs Contributes to Ethanol-Induced Liver Injury"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Platelets Upregulate S100A8, a Mediator of Endothelial Dysfunction and Inflammation, in Alcohol-Associated Hepatitis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol-Mediated Changes in Organ Metabolism
9:00 am - 9:20 am
"New Insight into Alcohol Metabolism, Organ Damage and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Protective Effects of FGF21 Against Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Skeletal Muscle in Alcohol-related Liver Disease- Organelle and Metabolic Responses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Alcohol and Clinical Effects on the Metabolic Syndrome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Combined Synthetic Cannabinoids and Alcohol Intoxication Induces Detrimental Cardiac Consequences: Role of CB1-R Signaling."
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Alcohol-Induced Oxidative Stress in Myocardium"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Role of Lymph from Alcohol-Treated Animals on Naïve Perilymphatic Adipose Tissue Immunomodulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Retinoid Stores Attenuate Deleterious Effects of Alcohol on Pancreas"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cancer Stem Cells and Alcohol-Associated Cancer
7:40 pm - 8:00 pm
"Alcohol and Colorectal Cancer: an Epidemiologic Perspective"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Alcohol and Colon Cancer: The “Clock” is Ticking"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Metabolic Reprogramming of Liver Tumor Initiating Cells"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Hepatocellular Carcinoma in NAFLD and ALD Occur via Distinct Stemness Activation And Metabolic Reprogramming in Diabetic Mice"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:35 pm
"Alcohol-Sensitized Macrophages Promote Colorectal Liver Metastasis"
9:35 pm - 9:40 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery of Mechanism-Based Biomarkers
9:00 am - 9:20 am
"The Degradome as Biomarkers and (Potentially) Mediators of Alcohol Organ Damage"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Extracellular Vesicle Signature Induced by Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Single Cell RNA Sequencing insights into the role of Kupffer cell subsets in progression of Alcohol-Associated Liver Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Non-Coding RNAs and Survival Outcomes in Patients with Alcohol-Associated Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Differential Expression of miRNA Cargo in Extracellular Vesicles Released from Adipocytes and Myotubes of Chronic Binge Alcohol-Administered SIV-infected Male Macaques"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Targeted Metabolomics of Gut Derived Microbial Metabolites in Alcohol-Associated Liver Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"ALPACA score: Development and Validation of a Score to Predict Risk of Liver-Related Events in Early Alcohol-Related Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Proteomic Analysis of Alcohol-Associated Hepatitis Reveals Glycoprotein NMB (GPNMB) as a Novel Hepatic Biomarker"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Concepts for Alcohol-Associated Organ Diseases
7:30 pm - 7:50 pm
"Alcohol-induced Cardiac Injury and Human iPSC for Cardiac Cell Therapy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Drug Targets for Treatment of Alcoholic Plus non-Alcoholic Steatohepatitis in Patients"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Folate Supplementation Protects Cardiac Outflow Tract Development from Synergistic Teratogenic Effects of Prenatal Alcohol Exposure and Notch Pathway Mutations"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"NLRP3-Dependent ASC Specks Released by Hepatocytes and Macrophages Perpetuate Inflammation in Alcoholic Hepatitis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Pericentral Gene Expression and Proliferation, Two Features Impaired in Human Alcoholic Cirrhosis, are Stimulated by SZN-043 in a Chronic-Binge Alcoholic Hepatitis Model"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Chronic Alcohol Blocks Efficacy of Anti-PD1 Immunotherapy in Mice and Humans"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure