Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Alcohol Use Disorder Pathogenesis and Treatment
7:40 pm - 8:20 pm
"Environmental Impact on Alcohol-Related Liver Toxicity and Cancer: Assessing the Role of PFAS"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Nutrition Deficiencies and Nutrition Therapy in Alcohol Use Disorder/Alcohol-Associated Liver Disease"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Alcohol-Mediated Interference of Cellular Processes
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Alcohol Interference with the Continuum: From Proliferation to Senescence"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Alcohol-Mediated Metabolic Reprogramming Underlies the Nucleolar Stress of Premigratory Neural Crest Progenitors"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Cell-Molecule Circuitry of Metabolic Zonation and Liver Regeneration"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Targeting Protein Tyrosine Phosphatases in Alcohol-Associated Liver Disease"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Altered Immune Microenvironment by Alcohol During Transition from Metabolic Disfunction-Associated Steatohepatitis to Hepatocellular Carcinoma"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Chronic Ethanol Insult Increases HSD17B 13 on Hepatocellular Lipid Droplets Via a Loss of an Associated Segregase P97/VCP to Promote Hepatic Steatosis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Defining the C5 Complosome as a Critical Coordinator of Alcohol-Induced Inflammatory Liver Macrophage Phenotypes"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"PDK4-Mediated Formation of the Ca2+-Channeling Complex at the ER-Mitochondria Interface Contributes to the Development of Alcohol-Associated Liver Disease"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Alcohol Associated Cellular Injury and Death
7:30 pm - 7:50 pm
"miR-150 and Tissue Crosstalk: Insights into Alcohol-Induced Liver Injury"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Stress Responses and Proteostasis regulators in Alcohol Associated Liver Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Regulation of Fibrogenesis by cAMP-Specific Phosphodiesterase 4 Enzymes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Investigating Intestinal Autophagy in the Context of Alcohol-Driven Tissue Injury"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer and Epigenetics of Alcohol
9:00 am - 9:20 am
"Integrating -Omics Techniques to Dissect the Role of Alcohol in Oral Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Alcohol, Liver and Kidney Injury and Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Alcohol Consumption Promotes Liver Metastatic Niche"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Impact of Alcohol on Prostate Cancer Aggressiveness"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Novel Role of STARD10 in ERBB2-Mediated Lipogenesis in Alcohol-Associated Liver Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Immunopeptidome Profiling of Alcohol-Associated Liver Damage in Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Disruption of Receptor-Interacting Protein Kinase 1 Post-Translational Modifications in Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Immune and Gut Microbial Disruptions in High Drinking in the Dark Mice: An Unexpected Result of Selective Breeding for Heightened Voluntary Alcohol Consumption"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immune-Mediated Mechanisms of Alcohol-Related Organ Damage
7:30 pm - 7:50 pm
"Alcohol in Autoimmunity: The Interplay Between Immune System, Gut Microbiome and Gut-Brain Axis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Aftermath of Binge Drinking: Loss of Gut Integrity and Cardiovascular Dysfunction"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Alcohol-Induced Alterations in Hyaluronan Dynamics May Cause Mitochondrial Derangements and Phagocytic Dysfunction in Alveolar Macrophages"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Monocytes Isolated from Non-Human Primates After Intermediate Alcohol Use More Closely Emulate the Phenotype Observed After Acute Alcohol Exposure When Compared to Chronic Alcohol Misuse"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Determining the Role of Inflammation in Alcohol-Induced Bone Loss"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome, Barrier Dysfunction and Trafficking
9:00 am - 9:20 am
"Alcohol Mediated Pathogenic Mechanisms in the Gut/Immune-Liver-Brain Axis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Hidden Cost of Alcohol Consumption: The Microbiota-Gut-Brain Axis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Goblet Cell-Mediated Neuro-Immune Defense: Protecting Against Alcohol-Related Liver Injury"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Alcohol Dysbiosis Linked to Frailty"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Alcohol and Gut Microbiota in Trials"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Gut Microbiota in Auto-Brewery Syndrome: Pathologic Microbial Ethanol Production and Treatment with Fecal Microbiota Transplantation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Alcohol and Metabolic Stressors Synergistically Increase Triglycerides and Reactive Oxygen Species Whereas Metabolic Stressors Drive Decreased Mitochondrial Respiration in a MetALD Spheroid Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol and Alterations in Nutrition and Bioenergetics
7:30 pm - 7:50 pm
"Fueling Metabolism: The Intersection of Calorie Dense Diets and Alcohol"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Role of Gut Hormones in Organ Crosstalk and the Development of ALD"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Interaction of the Molecular Clock and Mitochondria in Alcohol-Associated Liver Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Alcohol Metabolism Potentiates Bioenergetics Dysregulation in HIV-infected Alveolar Macrophages"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Paneth Cell Specific TCF4 Exacerbates Alcohol-Induced Dysbiosis of Gut Microbiota and Tissue Injury at the Gut-Liver Axis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Alcohol Metabolism and Oxidative Stress and Distress
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Alcohol Metabolism Disrupts Hepatic Thiol Redox Signaling and Control"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Redox-Associated Posttranslational Modifications of Liver Proteome in Hepatic Metabolic and Stress Response to Alcohol"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"The Effect of Alcohol on HBV Progression and Macrophage Anti-HBV Immune Responses"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Superoxide Dismutase 1: An Old Enzyme with a New Role?"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Chronic Alcohol Consumption Reprograms Hepatic Metabolism Through Organelle-Specific Acetylation in Mice"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Elucidating Wnt/?-Catenin Signaling as a Critical Modulator for Alcohol-Induced Fibrogenic Reprogramming in Models of Alcohol-Associated Liver Disease"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Chronic Heavy Alcohol Consumption Improves the Ability of Hematopoietic Stem and Progenitor Cells to Develop into Osteoclast Precursors"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Altered Retinoic Acid Signaling as a Broad Pathophysiological Mechanism of Alcohol-Induced Multiorgan Injury"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol-Induced Alterations of Extracellular Matrix Remodeling and the Matrisome
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Hepatic Stellate Cells in NASH and MetALD"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"ECM Modifications: A Mechanism of Alcohol-Mediated Cardiac Injury"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Dual Use of Nicotine Vaping and Chronic, Binge Alcohol: Cardiovascular Outcomes in a Mouse Model"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Alcohol Use Impairs Innate Immune Cell Metabolism and Effector Function Molecule Trafficking"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure