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Alcohol-Induced End Organ Diseases (GRS)

Gordon Research Seminar

Mechanisms Driving Heterogeneity in Ethanol-Induced Organ Injury

March 15 - 16, 2025

Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Alcohol-Induced End Organ Diseases GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Why do only a subset of people with alcohol-use disorder (AUD) develop organ injury? This seminar is designed to investigate the genetic and environmental factors and comorbidities that modulate the risk of developing ethanol-induced organ injury. We will explore how variables such as sex, environmental toxicants, diet, etc. affect different mechanisms of ethanol-induced organ injury.

Related Meeting

This GRS will be held in conjunction with the "Alcohol-Induced End Organ Diseases" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Alcohol as an Immune Toxicant Discussion Leader:
3:45 pm - 4:25 pm	"Addiction and Beyond: Alcohol as an Immune Toxicant"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Effect of Sex and Genetics on Alcohol-Induced Organ Injury Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:50 pm	"Immune and Gut Microbial Disruptions in High Drinking in the Dark Mice: An Unexpected Result of Selective Breeding for Heightened Voluntary Alcohol Consumption"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	"Disruption of Receptor-Interacting Protein Kinase 1 Post-Translational Modifications in Alcohol-Associated Liver Disease"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	"Alcohol Use Impairs Innate Immune Cell Metabolism and Effector Function Molecule Trafficking"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:50 pm	"Dysregulated HNF4a Isoforms and its Effects in Alcohol-associated Hepatitis"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:10 pm	"RIP3 and MLKL modulate hepatic ER stress: insights into non-canonical roles beyond necroptosis"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	How Diet and Environment Shape Alcohol-Induced Organ Injury Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:20 am	"Defining the C5 Complosome as a Critical Coordinator of Alcohol-Induced Inflammatory Liver Macrophage Phenotypes"
9:20 am - 9:25 am	Discussion
9:25 am - 9:40 am	"Dual Use of Nicotine Vaping and Chronic, Binge Alcohol: Cardiovascular Outcomes in a Mouse Model"
9:40 am - 9:45 am	Discussion
9:45 am - 10:00 am	"Urinary Proteomics Identifies Complement as Potential Biomarkers in Severe Alcohol-Associated Hepatitis Patients"
10:00 am - 10:05 am	Discussion
10:05 am - 10:20 am	"CD4 T Cells and Alcohol Produce Cellular Injury in a Hepatocyte Spheroid Model"
10:20 am - 10:25 am	Discussion
10:25 am - 10:40 am	"Alcohol-Induced Disruption of Gut Hormone and Neurotransmitter Expression in Enteroendocrine Cells: Evidence for Peripheral Nervous System Involvement in AUD"
10:40 am - 10:45 am	Discussion
10:45 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Tools and Strategies to Optimize the Mentee-Mentor Relationship Discussion Leader:
1:30 pm - 2:15 pm	"Navigating the Complex World of Mentorship: Tools & Strategies for Success"
2:15 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

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Conference History Alcohol-Induced End Organ Diseases

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