Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Genomic Discoveries in MND
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Defining the ALS "Mutome" to Inform Disease Mechanism and Target Identification"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Using Spatial Genomics to Identify Cellular Mechanisms of Cognitive Impairment in ALS-FTD"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Large-Scale Exome Analysis Reveals Rare Variant Contributions to ALS and Identifies Novel Risk Genes: What's Next?"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Long-Read Sequencing to Capture Genomic and Transcriptomic Signatures of ALS and Related Disorders"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Architecture of MND
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Molecular Visualization of TDP43 In Situ "
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Annexin A11 Aggregation in FTLD-ALS"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structural Model for TDP-43 C-Terminal Domain Multimer Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dysfunctional RNA Metabolism
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Unraveling Epitranscriptomic and Epigenetic Dysfunctions in ALS"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Molecular Modifiers of TDP-43 Pathobiology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Role of Alternative Polyadenylation in ALS: From Mechanistic Pathways to Therapeutic Opportunities"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Dissecting the Molecular Determinants of FUS Function"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Non-Neuronal Contributions to MND
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Contribution of Astrocytes to C9orf72-Mediated Cortical Neurodegeneration"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Myelination and Neuroprotection by Oligodendrocytes"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Deciphering the Glial Functions of TDP-43"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Motor Neuron Degeneration Triggered by Blood–Spinal Cord Barrier Breakdown"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress and Stressors in MND
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Nuclear TDP-43 Condensation in Stress and ALS"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Endogenous Retroviruses Trigger, Sustain, and Propagate TDP-43 Protein Pathology"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"mRNA Regulation in Health and Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Next-Generation Human Neuromuscular Models to Study ALS"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Defining TDP-43-Dependent Molecular Defects in CNS Cells"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Working Well With Mice and Some New Mouse Models for ALS Research"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"TDP-43-Dependent Dysregulated Splicing: Novel Mechanisms and Unexpected Targets"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neural Circuits Relevant to MND
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Pathological Mechanisms Associated With Altered Excitability in ALS"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Brain Motor Function and the Pathophysiology of ALS"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"A Mouse Model of ALS Caused by Sphingolipid Dysregulation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Towards a TDP-43 LOF Blood Test for ALS"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Biomarkers for ALS Therapy Development: Old Friends and New Acquaintances"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Peripheral Minimally Invasive Biomarkers of Early Disease in MND"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Therapeutic Strategies for MND
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Genetic and Pharmacological Screens Identify New Therapeutic Targets in ALS and FTD"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Exploring New Therapeutic Approaches for ALS and ALS/FTD"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Countering Deleterious Phase Transitions in ALS"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure