Sunday PM

Introduction

• "A Brief History of Combinatorial Chemistry (with apologies to Stephen Hawking)", A. Czarnik, IRORI Quantum Microchemistry

Monday AM

Synthesis Strategies for Combinatorial Libraries

• "Solid-Phase and Combinatorial Synthesis", M. Pirrung, Duke Univ.
• "High Throughput Molecular Science - A Parallel Universe", J. Hogan, Arqule Inc.
• "Synthesis of Heterocyclic Combinatorial Libraries: Application to the generation of molecular diversity and drug discovery", M. Desai, Chiron Corp.

Monday PM

New Analytical Faculty Symposium

• Prof. Yen-Ho Chu, Ohio State Univ. - "Combinatorial Library Screening with and without Affinity Capillary Electrophoresis"
• Prof. Sylvia Daunert, University of Kentucky - "Sensing Systems Based on Genetically Engineered Proteins and Cells"
• Prof. Steve Buratto, Univ. of Calif., Santa Barbara - "Nanoenvironments in Organic Thin Films: A Near-Field Scanning Optical Microscopy Study"
• Prof. Robert Dunn, Kansas University - "Probing Protein Channel Dynamics at the Single Molecule Level"
• Prof. Chris Evans, University of Michigan - "Nanoscale Management using Monolayer Polymers"
• Prof. Sheryl Tucker, University of Missouri - "Spectroflourometric Characterization of Starburst PAMAM Dendrimers"
• Prof. Dan Raftery, Purdue University - "Sensitivity and Resolution Enhancement for Solid-State NMR Studies of Surfaces"
• Prof. Darryl Bornhop, Texas Tech. - "Micro-Interferometric Backscatter for Multi-Modal Detection"

Tuesday AM

High Throughput Screening

• "Integrated approaches to accelerated drug discovery using combinatorial libraries", Jonathan Burbaum, Pharmacopeia
• "Exploiting Combinatorial Chemistry Libraries: Fluorescent Molecular Sensors For High Throughput Screening", Gregor Zlokarnik, Aurora Biosciences
• "Yeast cell based screening assays", Lauren Silverman, Cadus Pharmaceutical

Tuesday PM

Tagging, Where Has my Bead Been?

• "Prospects for combinatorial library screening with mass spectrometry", Nick Winograd, Penn St. Univ.
• "No Static At All: Combinatorial Organic Synthesis Using Radiofrequency Memory Tags", Tony Czarnik, IRORI
• "Encoded Combinatorial Libraries of Molecular Forceps", Peter Nestler, Cold Spring Harbor Labs.

Wednesday AM

High through-put analysis: Can I know what I made?

• "High-Resolution NMR in Combinatorial Chemistry: Solid-Phase-Synthesis Resins and High-Throughput Spectroscopy (VAST-NMR)", Paul Keifer, Varian
• Bill Fitch, Affymax Research Institute
• "New tools for monitoring organic reactions on solid supports", Bing Yan, Novartis

Wednesday PM

Using Chemical Libraries as a Research Tool

• "Finding Catalysts in Combinatorial Libraries", Eric Jacobsen, Harvard U.

Poster session 8:00 to 10:00

Thursday AM

Instrumentation for Automated Synthesis

• "Automated High-Throughput Synthesis: Achievements and Challenges", Sheila Hobbs Dewitt, Parke Davis
• "A Manufacturing Approach To Automating High Throughput Screening and Combinatorial Chemistry", Don Rose, Cartesian Engineering
• "New Strategies for Automated Chemical Synthesis", John A. Porco, Jr., Argonaut Technologies

Thursday PM

Late Breaking Research

• "DNA Computing on Surfaces", Lloyd Smith, University of Wisconsin
• "Diagnostic Applications of Aptamers", Andrew Ellington, Indiana University