Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Paradigm Shifts in the RAAS
Keynote lectures by Dr. Ariel Gomez and Dr. David Harrison.
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Control of Renin Cell Identity in Homeostasis and Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Insights into the Role of RAS and Other Hypertensive Stimuli in Immune Activation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Additional RAS Signaling Mechanisms / Novel Functions of Renin Cells
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"20-HETE-RAS Interactions in Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Cardiovascular Ageing Regulated by Heterodimerization of Angiotensin AT1 Receptor with Purinergic P2Y6 Receptor"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:40 am
Introduction by Discussion Leader
10:40 am - 11:05 am
"The Juxtaglomerular Apparatus: A Renin Lineage Precursor Cell Niche for Glomerular Regeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"The Origin, Fate, and Significance of Renin Progenitors During Hematopoiesis"
11:40 am - 11:50 am
Discussion
11:50 am - 11:55 am
Introduction by Discussion Leader
11:55 am - 12:10 pm
"Loss of Urine Concentration and Subsequent Dehydration Characterizes Hypertension in Rats with Chronic Renal Failure"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondrial Fission Mediates Hypertensive Vascular Remodeling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cross-Talk with Angiotensin Receptors
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Soluble (Pro)renin Receptor: Its Generation and Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"(Pro)renin and Wnt/Beta-Catenin Signaling in Chronic Kidney Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
"Cleavage of the Soluble Prorenin Receptor and the Implications for Preeclamptic Pregnancies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Big Angiotensin-25: A Novel Component of the Renin Angiotensin System"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Neural Control Mechanisms: Does the Brain Dominate the Circulation?
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Shedding Light on the Role of 'Angiotensin-Sensitive' Neural Circuits in the Coordination of Neuroendocrine and Autonomic Control"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Brain RAS, Inflammation and Blood Brain Barrier Integrity: Opposite Effects of Hypertension and Exercise Training"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:45 am
Introduction by Discussion Leader
10:45 am - 11:10 am
"Role of the Brain Angiotensin System in Chronic Intermittent Hypoxia Induced Hypertension"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Microglial Activation Regulate Blood Pressure in Ang II Hypertension"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Leptin Modulates the RAS Within the Arcuate Nucleus to Stimulate Resting Metabolic Rate"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Melanocortin 3 Receptor Deletion Induces Skin-Specific Na and Water Loss that Cannot Be Compensated by Glucocorticoid-Driven Urea Osmolyte Generation and Accumulation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bench Comes to the Real World: MR and Its Antagonist
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Repositioning Mineralocorticoid Receptor Antagonists: Pathophysiological and Clinical Insights"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Putting the 'A' Back into RAAS: Mineralocorticoid Signalling in Cardiovascular Disease"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 8:55 pm
"Mineralocorticoid Receptro in Renal Intercalated Cells Mediates Pendrin Regulation by Renin-Angiotensin-Aldosterone System to Maintain Fluid Homeostasis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Angiotensin II Type 2 Receptor Stimulation Decreases Sensory Neuropathy Induced by Vincristine in Mice"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mitochondrial Fission Is Regulated by Canonical NF-kB Signaling and Is Required for Vascular Inflammation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gut Microbiome, Immunity, Salt-Sensitive Hypertension and the RAAS
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Brain-Gut Interactions and RAS in Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Hypertension and Gut Microbiota: Links and Treatment"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Angiotensin-Converting Enzymes Enhances the Oxidative Response and Bactericidal Activity of Neutrophils"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:15 am
Introduction by Discussion Leader
11:15 am - 11:40 am
"Vascular Rho Kinase and RAS in Ageing-Associated Salt-Sensitive Hypertension"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Smooth Muscle PPARgamma Mutation Causes Salt-Sensitive Hypertension"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"The ACE N-Domain Plays an Active Role in Renal Inflammation and Sodium Retention During Diabetes Independently from Angiotensin II Generation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Approaches Open New Windows into RAS Function
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Smooth Muscle RhoBTB1 Is a Novel Regulator of Vascular Function, Arterial Stiffness and Blood Pressure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Central-Acting Aminopeptidase A Inhibitors for New Treatment of Hypertension and Heart Failure: From Discovery to Clinical Trial"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
"Treating Stroke via the Nose to Brain Highway: Intranasal Delivery of Angiotensin Type 2 Receptor Agonist After Ischemic Stroke Is Neuroprotective"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"First-in-Man Clinical Evaluation of an Angiotensin AT2-Receptor Agonist in a Phase I, Randomised, Double-Blind Clinical Trial Revealed Safety, Tolerability and a Beneficial Effect on Lipoprotein Pattern"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Angiotensin: Possible Key for Immune Response
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"A Vascular Coagulation-Inflammatory Circuit in Arterial Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Targeting Novel Immune Signaling in Hypertension"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:50 am
Introduction by Discussion Leader
10:50 am - 11:15 am
"Role of AngII in Neuroinflammation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Activation of Natural Killer Cells in Recombination Activating Gene 1 Null Mice with Angiotensin II Induced Hypertension"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Role of AT1 Receptor-Mediated ADAM17 Signaling in Glutamatergic Neurons in Neurogenic Hypertension"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"NI956: A Potent Orally Active Aminopeptidase A Inhibitor with Central Antihypertensive Effects in DOCA-Salt Rats"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Immunosuppression in Type 2 Diabetes Is Improved with A(1-7) Treatment in a S. aureus Infection Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex, Aging and Death in the RAAS
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Sudden Death in Muscular Dystrophy: Role of the Renin-Angiotensin System"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Sex Differences and Aging in the RAS"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
"Chronic Treatment of Short Chain Fatty Acids Attenuates the Development of Atherosclerosis in Angiotensin II Infused Apolipoprotein E Deficient Mice"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Loss of Interleukin 21 Protects Against Hypertension and Hypertension Associated Inflammation and End-Organ Damage"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure