Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Harnessing Antibodies Against Disease
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"The Past, Present, and Future of Antibody Drug Conjugates for Cancer Therapy"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Regulation of Adaptive and Innate Immune Functions by Antibodies"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"A Strategic Framework for Successful Translation of Antibody-Drug Conjugates from Concept to Clinic"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"PK/PD Evaluation of ADC Therapeutic Index Optimization via Antibody Engineering"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:10 am
"A Novel Highly Potent Kinase Degrader Payload and its use in Antibody Conjugates"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Peptide Tag-nology for Preparation of Site-specific Antibody Drug Conjugates"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Establishing a High-Throughput Selection System to Develop Fast-Acting Covalent Protein Drugs with Enhanced Therapeutic Activity"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Biepitopic Targeting Design for Antibody-Drug Conjugates Learned from cis- Binding Biparatopic Antibodies"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Functional Screening Platforms for Antibody Engineering and Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Structural and Dynamic Landscape of Antibody–Antigen Recognition: From Structure to Machine Learning Guided Antibody Design"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Endogenous PD-L1-Blocking Antibodies Drive Potent Anti-Tumor Immunity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"An Integrated Serological Platform for Airway-Delivered Next Gen and Universal Broadly Neutralisng mAb Immunogenicity Readouts: Influenza HA and NA"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Multiplexed Anti-Glycan Antibody Discovery Using DNA-Barcoded Neoglycoproteins Coupled with Single Cell Sequencing"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
B Cell and Antibody Biology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"IgG B Cell Receptor Mutations Promoting Germinal Center-Derived B Cell Lymphomas"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Biology of Human Antigen-specific Plasma Cells at a Single Cell Level"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Autoantibodies in Neuropsychiatric Diseases: From Mechanisms to Novel Treatments"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Sugar-Coated or Protein-Packed? How Antigen Type Shapes the B Cell Response to Mucosal Bacterial Infection in Humans"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Biophysical Trade-offs in Antibody Evolution are Resolved by Conformation-Mediated Epistasis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Increasing Hemagglutinin Head Epitope Diversity Enhances Stalk-Specific Long-lived Humoral Immunity"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative Applications of B cells and Antibodies
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"In Vivo B Cell Engineering"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Genetically Engineered B Cell Medicines for Sustained in Vivo Delivery of Therapeutic Biologics"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Genetically Encoded Intrabodies for Subcellular Control of Kinase Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Serology 2.0: Integrated Antigen-Specific Fab Profiling Unveils the Composition, Cross-Reactivity and Distribution of Autoantibody Repertoires in Rheumatoid Arthritis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Nanodiscs for Antibody Analysis in Vaccine Development"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Unique Antibody Formats and Multispecifics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Conquering The Last Frontier: Developing Ion Channel Modulating Antibodies"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Temperature-Driven Antibody Specificity: An Unconventional Immune Strategy in Bats"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Targeting Glycans for Immunotherapy"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Enabling Polyclonal Antibody Production Through Fc-Engineering of Mutual Exclusive CH3 Interfaces"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"NKp30-Directed Bispecific Natural Killer Cell Engagers for the Treatment of B Cell Neoplasia"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Strategies Addressing the Heavy-Light Chain Pairing Challenge of Bispecific Antibodies : A Work in Progress Case Study"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Antibody Engineering and Conditional Targeting
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Beyond the "Vanilla" IgG: Elucidating the Structure-PK Relationship of Complex Antibody Formats and Understanding the Underlying Mechanisms for Improved Drug Design"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Pairing and Assembly in Antibodies: From B Cell Selection to Protein Engineering"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Subcutaneous Antibody-Conjugated Microgel (ANGel) Platform Enabling Combination Immunotherapy for Refractory Solid Tumors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Neuronal Gene Modulation Using Bispecific Antibody-Oligonucleotide Conjugates"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Development and Engineering of VHH Antibodies Targeting Plexin-B2"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Antibodies and Vaccines to Infectious Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Target Medicine Profile, Engineering and Discovery of Broadly Protective mAbs for Infectious Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Characterization of Viral Antigen Supersites in Human Vaccine Studies"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Fc Engineering to Resist Antibody Capture by Viral Receptors Enhances Host Responses Against HCMV"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"VX-01, A Humanized Anti-Angioinvasion Monoclonal Antibody Targeting Lethal Mucormycosis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Engineered Secretory IgA Provides Insights into Antibody-Mediated Protection Targeting Clostridioides Difficile"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Intracellular Antibody Neutralization Correlates with Vaccine-Induced Protection Against Rotavirus in Infants"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Antibody Effector Functions
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Bispecific Complement Engagers (BiCEs) - Harnessing Complement Activation for Enhanced Antibody Therapy"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Immunotherapy Targeting Intracellular Tau Pathology in Neurodegeneration"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Engineering of Bispecific CD19 Antibodies to Engage Macrophages by Triggering Activating Fc Gamma Receptors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Fc Conformational Flexibility Promotes Immunoglobulin G Hexamer Formation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"How Does Human IgG1 Fc Engineering for FcRn Mediated Half-Life Extension Affects TRIM21 Engagement and Effector Functions?"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure