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Autophagy in Stress, Development and Disease

Gordon Research Conference

Autophagy: Basic Biology, Aging and Age-Related Diseases

March 18 - 23, 2018

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

Autophagy is a fundamental biological process that impacts nearly all facets of human health, including a number of age-related diseases, such as neurodegeneration, cancer, infection and immunity, inflammation and allergy, metabolic diseases and diabetes, muscle atrophy, as well as the aging process itself. The growing realization of the broad impact of autophagy in human health is in part the result of vigorous scientific exchange facilitated by previous Gordon Research Conferences on autophagy. The 2018 GRC meeting on autophagy will be instrumental in communicating the newest molecular insights of the role and regulation of autophagy in aging and age-related disorders, with the goal of facilitating translation of the presently acquired knowledge into drugs and novel treatments for such diseases.

Related Meeting

This GRC will be held in conjunction with the "Autophagy in Stress, Development and Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Organelle Trafficking Discussion Leader:
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 8:10 pm	"Regulation of Autophagy by the Trafficking Machinery"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:40 pm	"Insights into the Mechanism of Autophagosome Biogenesis from Yeast"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:10 pm	"Coincident Detection of PI3P-RAB11A by WIPI2 Enables Autophagosome Formation on RAB11A-Positive Compartment"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Lysosomes: The Final Destination Discussion Leader:
9:00 am - 9:20 am	"Lysosomes and Endolysosomes: The Dynamics of the Late Endocytic Pathway"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"The Lysosome Cargo Response"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: "Regulation of Endosomal Microautophagy in Drosophila"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	Selected from Poster Abstracts: "LC3 Phosphorylation Is Critical for Directional Transport of Autophagic Vesicles"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Signalling Networks Controlling AMPK Activation and Autophagy"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Role of the Autophagic Protein, STX17, in Melanogenesis and Alopecia Areata"
11:45 am - 11:50 am	Discussion
11:50 am - 12:10 pm	"Cross-Talk Between mTORC1 and TFEB Regulates the Adaptive Response to Nutrient Availability and Promotes Cancer Growth"
12:10 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizers: and
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Basic Biology of Autophagy Discussion Leader:
6:00 pm - 6:20 pm	"Novel Roles of Autophagy in Vertebrate Development"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Selected from Poster Abstracts: "Autophagy Contributes to Somatic Cell State Reprogramming in Plants"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"New Insights into Autophagic Regulation and Anti-Disease Function"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:30 pm	"How Rubicon Allosterically Inhibits Membrane Docking by the Autophagic PI 3-Kinase Complex"
7:30 pm - 7:35 pm	Discussion
7:35 pm - 7:45 pm	Selected from Poster Abstracts: "COPI Complex Depletion: ROS, Lipid Droplets and Autophagy"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Basic Mechanisms of Autophagosome Formation Discussion Leader:
9:00 am - 9:20 am	"Regulation of Autophagosome Formation"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Molecular Regulation of Autophagy: Atg1/ULK1 and Friends"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: "Eukaryotic Translation Initiation Factor 5A Mediates Translational Control of Autophagy via ATG3"
10:10 am - 10:15 am	Discussion
10:15 am - 10:35 am	"The Molecular Mechanism Underlying Establishment and Maintenance of the ER/Isolation Membrane Contact"
10:35 am - 10:45 am	Discussion
10:45 am - 11:15 am	Coffee Break
11:15 am - 11:35 am	"Role of Lipid Synthesis in Autophagosome Biogenesis"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	Selected from Poster Abstracts: "Acyl-CoA Synthetases Activate Fatty Acids on Forming Autophagosomes to Drive Autophagy"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: "Lipid Metabolism in the Regulation of Autophagy and Ageing in Yeast"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: "Influenza A Infection Triggers a Cellular Response that Resembles Autophagy but Has a Distinct Molecular Basis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Selective Autophagy Discussion Leader:
6:00 pm - 6:20 pm	Alexander M. Cruickshank Lecture: "Selective Autophagy and ER Remodelling"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Selected from Poster Abstracts: "Targeting the Membranous Shelters of Pathogens via Autophagy Proteins"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"Regulation of Selective Autophagy by Lipid-Binding Proteins"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	Selected from Poster Abstracts: "Regulation of Nix-Mediated Mitophagy by Dimerization and Phosphorylation"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"How Cells Deploy Autophagy to Defend Against Invading Bacteria"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Inflammation and Immunity Discussion Leader:
9:00 am - 9:20 am	"Role of ATG Genes in Regulating Inflammation and Immunity"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Selected from Poster Abstracts: "The WD40 Domain of ATG16L1 Supports Non-Canonical Autophagy and Dendritic Cell Antigen Presentation"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Selected from Poster Abstracts: "Kenny Mediates Selective Autophagic Degradation of the IKK Complex to Control Innate Immune Responses"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: "Translational Control of Autophagy Rejuvenates Immune Responses via eIF5A and TFEB"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"How Innate Immune Functions of Autophagy Teach Us About Its Fundamental Mechanisms"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Autophagy, Microbial Sensors and Mucosal Immunity"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	Selected from Poster Abstracts: "Atg14 Protects the Intestinal Epithelium from TNF-Induced Apoptosis"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	"Defining an LC3-Dependent Functional Circuit that Specifies Exosome Loading and Secretion"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Drug Discovery Discussion Leader:
6:00 pm - 6:20 pm	"Intrinsic and Extrinsic Roles of Autophagy in Tumors"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Selected from Poster Abstracts: "Phenotypic Screening Paradigms for Autophagy Pathway Regulators"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	Selected from Poster Abstracts: "Development of New PLGA Nanoemulsion Formulation to Restore Lysosomal Dysfunction in Parkinson's Disease"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Malfunctioning of Chaperone-Mediated Autophagy in Aging and Age-Related Diseases"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	General Discussion: Target Autophagy to Improve Healthspan
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm	Age-Related Diseases Discussion Leaders: and
9:00 am - 9:20 am	"Lysosomal pH Regulation: Emerging Roles in Neurodegenerative Disease"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	Selected from Poster Abstracts: "Mitophagy as a Regulator of Metabolism and Cell Differentiation"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Selected from Poster Abstracts: "Defective Axonal Autophagosome Maturation in AP-4 Deficiency Syndrome"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: "Understanding the Potential Role for Dysregulation of Autophagy Complexes, ULK1 and PI3KC3, in Predisposing Pathogenesis of Alzheimer's Disease"
10:10 am - 10:15 am	Discussion
10:15 am - 10:40 am	Coffee Break
10:40 am - 11:00 am	"Autophagy and Cancer-Lessons from Drosophila"
11:00 am - 11:10 am	Discussion
11:10 am - 11:30 am	"Autophagy in Cell Death and Cancer"
11:30 am - 11:40 am	Discussion
11:40 am - 11:50 am	Selected from Poster Abstracts: "Exploring the Molecular Mechanism of Hif-2a-Mediated Pexophagy and the Role of Pexophagy in Tumorigenesis"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Modulation of Collagen Trafficking by Autophagy as a Therapy for Bone Disorders"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Differential Roles of Chronic Autophagy in Insulin Production and Sensitivity"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Autophagy in Aging Discussion Leader:
6:00 pm - 6:20 pm	"Mitochondrial Turnover and Neuronal Homeostasis During Ageing"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:45 pm	Selected from Poster Abstracts: "Non-Canonical Role of Autophagy in Neurotrophin Signaling and Axonal Homeostasis"
6:45 pm - 6:50 pm	Discussion
6:50 pm - 7:05 pm	Selected from Poster Abstracts: "The Autophagy Receptor SQSTM1/p62 Promotes Longevity in C. elegans"
7:05 pm - 7:10 pm	Discussion
7:10 pm - 7:25 pm	"RFLP is an mTOR Regulated Dynein Motor Adaptor Protein Required for Mammalian Autophagosome Assembly and Transport"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	General Discussion
7:50 pm - 8:00 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible, in part by 1R13AG056135-01A1 from National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Autophagy in Stress, Development and Disease (GRS)

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